ID A0A8C0BNL1_9AVES Unreviewed; 1024 AA.
AC A0A8C0BNL1;
DT 19-JAN-2022, integrated into UniProtKB/TrEMBL.
DT 19-JAN-2022, sequence version 1.
DT 28-JAN-2026, entry version 17.
DE SubName: Full=Cysteine rich transmembrane BMP regulator 1 {ECO:0000313|Ensembl:ENSBJAP00000018888.1};
OS Buteo japonicus.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Neoaves; Telluraves; Accipitrimorphae;
OC Accipitriformes; Accipitridae; Accipitrinae; Buteo.
OX NCBI_TaxID=224669 {ECO:0000313|Ensembl:ENSBJAP00000018888.1, ECO:0000313|Proteomes:UP000694555};
RN [1] {ECO:0000313|Ensembl:ENSBJAP00000018888.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (AUG-2025) to UniProtKB.
RN [2] {ECO:0000313|Ensembl:ENSBJAP00000018888.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2025) to UniProtKB.
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DR AlphaFoldDB; A0A8C0BNL1; -.
DR Ensembl; ENSBJAT00000019410.1; ENSBJAP00000018888.1; ENSBJAG00000012404.1.
DR Proteomes; UP000694555; Unplaced.
DR GO; GO:0005576; C:extracellular region; IEA:InterPro.
DR GO; GO:0005886; C:plasma membrane; IEA:TreeGrafter.
DR GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IEA:InterPro.
DR FunFam; 4.10.40.20:FF:000003; cysteine-rich motor neuron 1 protein isoform X1; 1.
DR Gene3D; 4.10.40.20; -; 1.
DR Gene3D; 6.20.200.20; -; 6.
DR Gene3D; 2.10.22.10; Antistasin, domain 1; 4.
DR InterPro; IPR004094; Antistasin-like.
DR InterPro; IPR052624; CRIM1.
DR InterPro; IPR045813; CRIM1_C.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR011061; Hirudin/antistatin.
DR InterPro; IPR000867; IGFBP-like.
DR InterPro; IPR001007; VWF_dom.
DR PANTHER; PTHR46439; CYSTEINE-RICH MOTOR NEURON 1 PROTEIN; 1.
DR PANTHER; PTHR46439:SF1; CYSTEINE-RICH MOTOR NEURON 1 PROTEIN; 1.
DR Pfam; PF02822; Antistasin; 4.
DR Pfam; PF19442; CRIM1_C; 1.
DR Pfam; PF00219; IGFBP; 1.
DR Pfam; PF00093; VWC; 4.
DR Pfam; PF23334; VWC2L_2nd; 2.
DR SMART; SM00121; IB; 1.
DR SMART; SM00214; VWC; 6.
DR SMART; SM00215; VWC_out; 3.
DR SUPFAM; SSF57603; FnI-like domain; 6.
DR SUPFAM; SSF57184; Growth factor receptor domain; 1.
DR SUPFAM; SSF57262; Leech antihemostatic proteins; 3.
DR PROSITE; PS51252; ANTISTASIN; 4.
DR PROSITE; PS51323; IGFBP_N_2; 1.
DR PROSITE; PS01208; VWFC_1; 3.
DR PROSITE; PS50184; VWFC_2; 6.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000694555};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..22
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 23..1024
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5034279400"
FT TRANSMEM 929..949
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 21..100
FT /note="IGFBP N-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51323"
FT DOMAIN 322..379
FT /note="VWFC"
FT /evidence="ECO:0000259|PROSITE:PS50184"
FT DOMAIN 389..445
FT /note="VWFC"
FT /evidence="ECO:0000259|PROSITE:PS50184"
FT DOMAIN 457..486
FT /note="Antistasin-like"
FT /evidence="ECO:0000259|PROSITE:PS51252"
FT DOMAIN 493..520
FT /note="Antistasin-like"
FT /evidence="ECO:0000259|PROSITE:PS51252"
FT DOMAIN 527..552
FT /note="Antistasin-like"
FT /evidence="ECO:0000259|PROSITE:PS51252"
FT DOMAIN 555..580
FT /note="Antistasin-like"
FT /evidence="ECO:0000259|PROSITE:PS51252"
FT DOMAIN 594..651
FT /note="VWFC"
FT /evidence="ECO:0000259|PROSITE:PS50184"
FT DOMAIN 665..723
FT /note="VWFC"
FT /evidence="ECO:0000259|PROSITE:PS50184"
FT DOMAIN 739..797
FT /note="VWFC"
FT /evidence="ECO:0000259|PROSITE:PS50184"
FT DOMAIN 805..862
FT /note="VWFC"
FT /evidence="ECO:0000259|PROSITE:PS50184"
SQ SEQUENCE 1024 AA; 112507 MW; 261E6EE5045EEE95 CRC64;
SCPGSIVLGI CGCCFMCSGT RALVCLPCDE SKCEEPKSCP GSIVLGICGC CFMCARQRNE
SCGGVYGLHG ACDRGLRCVI RPPLNGDSIT EYEVGVCEDE NWDDDQLLGF EPCNENLITG
CNIISGKCEC DTIRTCNNPF EFPSRDTCLS ALKRIEEEKP DCSKARCEVQ FSPRCPEDSI
LIEGYAPPGE CCPLPSRCVC NPAGCLRKVC QPGYLNILVS KASGKPGECC DLYECKPVFS
VDCSTVECPP VQQVVCPLDS YETQVRLTAD GCCTLPTRCE CLSGLCGFPM CEAGSVPQIV
SRGDGTPGKC CDVFECVNEV KPTCIFNSME YYDGDMFRMD ACRFCRCQGG VSICFSAQCG
ELHCDRYYVP EGECCPVCED PVYPINNPAG CYANGQIQAH GDRWREDDCT FCQCINGDPH
CVATACGQSC LNPVKVPGEC CPVCEEPTYI TIGPPTCEIL VNCTLTEKDC IYSFKLDQNG
CRICQCKTRE ELCTGLISGC SLDCSFGFQT DVHNCEICQC RPRPKKCKPI VCDKYCPFGY
LKNKHGCEIC RCKKCPDLPC GKICPMGFQQ NSHGCVICKC REATASLMPP VKTGSCLSMD
GRRHENEEGW HDGCRECYCH NGREMCALIT CPVPNCGNPT IHPGQCCPSC PDEIIVQKPE
LTSPSICHAP GGEYFVEGET WNIDSCTQCT CHSGRVLCET EVCPPLLCQN PTRTQDSCCP
QCPDEPLQPS SSSNESMPSY CKNDEGDIFL TAESWKPNVC TSCICMDGVI RCYSESCPLV
SCERPVLRKG QCCPYCIEDT VPKKVVCHFS GKTYADEERW DIDSCTHCYC LQGQTLCSTV
SCPPLPCAEP INVEGSCCPM CPEMYVPEPT NIPIEKTNHR GDIELEVPNW PTPSENDIIH
IHRDMSHLQG EYRSGSGPHP SEDASVSSVA LVTIPITIAL LLIIVLLLIN QKKQWIPVSC
YKAPTKPSCL NNQLVYVDCK KGTMVQVDSS QRMLRIADPD SRYSGFYSMQ KQNNLQADNF
YQTV
//
