ID A0A8C0GJY9_CHEAB Unreviewed; 268 AA.
AC A0A8C0GJY9;
DT 19-JAN-2022, integrated into UniProtKB/TrEMBL.
DT 19-JAN-2022, sequence version 1.
DT 28-JAN-2026, entry version 20.
DE SubName: Full=Kazal type serine peptidase inhibitor domain 1 {ECO:0000313|Ensembl:ENSCABP00000005722.1};
GN Name=KAZALD1 {ECO:0000313|Ensembl:ENSCABP00000005722.1};
OS Chelonoidis abingdonii (Abingdon island giant tortoise) (Testudo
OS abingdonii).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Testudinata; Testudines; Cryptodira; Durocryptodira;
OC Testudinoidea; Testudinidae; Chelonoidis.
OX NCBI_TaxID=106734 {ECO:0000313|Ensembl:ENSCABP00000005722.1, ECO:0000313|Proteomes:UP000694404};
RN [1] {ECO:0000313|Ensembl:ENSCABP00000005722.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (AUG-2025) to UniProtKB.
RN [2] {ECO:0000313|Ensembl:ENSCABP00000005722.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2025) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
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DR AlphaFoldDB; A0A8C0GJY9; -.
DR Ensembl; ENSCABT00000006223.1; ENSCABP00000005722.1; ENSCABG00000004291.1.
DR GeneTree; ENSGT00530000063555; -.
DR OMA; TWNITGQ; -.
DR Proteomes; UP000694404; Unplaced.
DR GO; GO:0005615; C:extracellular space; IEA:TreeGrafter.
DR GO; GO:0005520; F:insulin-like growth factor binding; IEA:InterPro.
DR GO; GO:0001558; P:regulation of cell growth; IEA:InterPro.
DR GO; GO:0009966; P:regulation of signal transduction; IEA:TreeGrafter.
DR CDD; cd00104; KAZAL_FS; 1.
DR FunFam; 2.60.40.10:FF:000032; palladin isoform X1; 1.
DR Gene3D; 3.30.60.30; -; 1.
DR Gene3D; 4.10.40.20; -; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR000867; IGFBP-like.
DR InterPro; IPR011390; IGFBP_rP_mac25.
DR InterPro; IPR017891; Insulin_GF-bd_Cys-rich_CS.
DR InterPro; IPR002350; Kazal_dom.
DR InterPro; IPR036058; Kazal_dom_sf.
DR PANTHER; PTHR14186; INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN-RELATED; 1.
DR PANTHER; PTHR14186:SF21; KAZAL-TYPE SERINE PROTEASE INHIBITOR DOMAIN-CONTAINING PROTEIN 1; 1.
DR Pfam; PF07679; I-set; 1.
DR Pfam; PF00219; IGFBP; 1.
DR PIRSF; PIRSF018239; IGFBP_rP_mac25; 1.
DR SMART; SM00409; IG; 1.
DR SMART; SM00408; IGc2; 1.
DR SMART; SM00280; KAZAL; 1.
DR SUPFAM; SSF57184; Growth factor receptor domain; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 1.
DR SUPFAM; SSF100895; Kazal-type serine protease inhibitors; 1.
DR PROSITE; PS50835; IG_LIKE; 1.
DR PROSITE; PS00222; IGFBP_N_1; 1.
DR PROSITE; PS51323; IGFBP_N_2; 1.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319};
KW Reference proteome {ECO:0000313|Proteomes:UP000694404};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..23
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 24..268
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5035000013"
FT DOMAIN 43..122
FT /note="IGFBP N-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51323"
FT DOMAIN 165..262
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
SQ SEQUENCE 268 AA; 29709 MW; B59FBD27E015DB58 CRC64;
MADQWQSWEK IPGLFRLCLM SLCRLLPTVL FEMSPSLGRL SHRSSDCSDC SPEECPMPRG
CLAGLVRDPC ECCWECANLE GQICDLDNTN HFYGKCGDHL ECKLDTGDLR KGEVPEPQCA
CLSSQTLCGS DGKTYAQICK FQEVFHAYPE ANLTVAHEGP CESEPQILSP PYDVWNITGQ
DVIFGCEVFA YPMASIEWRK DGAEILLPGD DPHISVQFRG GPQKYEVTGW LQIQGVRVTD
EGTYRCFARN RVGEVAALAS LTVLTPGK
//
