ID A0A8C0IG57_BUBBB Unreviewed; 593 AA.
AC A0A8C0IG57;
DT 19-JAN-2022, integrated into UniProtKB/TrEMBL.
DT 19-JAN-2022, sequence version 1.
DT 28-JAN-2026, entry version 19.
DE RecName: Full=Forkhead box protein P2 {ECO:0000256|ARBA:ARBA00040052};
OS Bubo bubo (Eurasian eagle-owl) (Strix bubo).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Neoaves; Telluraves; Strigiformes;
OC Strigidae; Bubo.
OX NCBI_TaxID=30461 {ECO:0000313|Ensembl:ENSBOBP00000018918.1, ECO:0000313|Proteomes:UP000694567};
RN [1] {ECO:0000313|Ensembl:ENSBOBP00000018918.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (AUG-2025) to UniProtKB.
RN [2] {ECO:0000313|Ensembl:ENSBOBP00000018918.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2025) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|PROSITE-ProRule:PRU00089}.
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DR AlphaFoldDB; A0A8C0IG57; -.
DR Ensembl; ENSBOBT00000019351.1; ENSBOBP00000018918.1; ENSBOBG00000011589.1.
DR Proteomes; UP000694567; Unplaced.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0001227; F:DNA-binding transcription repressor activity, RNA polymerase II-specific; IEA:TreeGrafter.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IEA:TreeGrafter.
DR GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-KW.
DR CDD; cd20065; FH_FOXP2; 1.
DR FunFam; 1.20.5.340:FF:000005; Forkhead box P1, isoform CRA_f; 1.
DR FunFam; 1.10.10.10:FF:000010; Forkhead box P2 isoform B; 1.
DR Gene3D; 1.20.5.340; -; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR047412; FH_FOXP1_P2.
DR InterPro; IPR001766; Fork_head_dom.
DR InterPro; IPR050998; FOXP.
DR InterPro; IPR032354; FOXP-CC.
DR InterPro; IPR030456; TF_fork_head_CS_2.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR45796; FORKHEAD BOX P, ISOFORM C; 1.
DR PANTHER; PTHR45796:SF9; FORKHEAD BOX PROTEIN P2; 1.
DR Pfam; PF00250; Forkhead; 1.
DR Pfam; PF16159; FOXP-CC; 1.
DR PRINTS; PR00053; FORKHEAD.
DR SMART; SM00339; FH; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS00658; FORK_HEAD_2; 1.
DR PROSITE; PS50039; FORK_HEAD_3; 1.
PE 4: Predicted;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW ProRule:PRU00089}; Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW ProRule:PRU00089}; Reference proteome {ECO:0000313|Proteomes:UP000694567};
KW Repressor {ECO:0000256|ARBA:ARBA00022491};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT DOMAIN 382..455
FT /note="Fork-head"
FT /evidence="ECO:0000259|PROSITE:PS50039"
FT DNA_BIND 382..455
FT /note="Fork-head"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00089"
FT REGION 1..41
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 159..217
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 316..343
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 527..546
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 556..593
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..28
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 170..183
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 193..202
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 204..215
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 316..337
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 577..593
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 593 AA; 65408 MW; B6588AE674BFB261 CRC64;
MMQESATETI SNSSMNQNGM STLSSQLDAG SRDGRSSGDT STEVSTVELL HLQQQQVSLF
CFLFVFKQIK GSFWTGTLLQ TLCQQQQLAA QQLVFQQQLL QMQQLQQQQH LLNLQRQGLI
SIPPGQSALP VQSLPQAGLS PAEIQQLWKE VTGVHSMEDN GIKHGGLDLT TNNSSSTTSS
TTSKASPPIT HHSIVNGQSS VLNARRDSSS HEETGASHTL YGHGVCKWPG CESVCEDFGQ
FLKHLNNEHA LDDRSTAQCR VQMQVVQQLE IQLSKERERL QAMMTHLHMR PSEPKPSPKP
LNLVSSVTMS KNMLETSPQS LPQTPTTPTA PVTPITQGPS VITPASVPNV GAIRRRHSDK
YNIPMSSEIA PNYEFYKNAD VRPPFTYATL IRQAIMESSD RQLTLNEIYS WFTRTFAYFR
RNAATWKNAV RHNLSLHKCF VRVENVKGAV WTVDEVEYQK RRSQKITGSP TLVKNIPTSL
GYGAALNASL QAALAESSLP LLSNPGLINN ASSGLLQAVH EDLNGSLDHI DSNGNSSPGC
SPQPHIHSIH VKEEPVIAED EDCPMSLVTT ANHSPELEDD REIEEEPLSE DLE
//
