ID A0A8C0UK85_CYACU Unreviewed; 919 AA.
AC A0A8C0UK85;
DT 19-JAN-2022, integrated into UniProtKB/TrEMBL.
DT 19-JAN-2022, sequence version 1.
DT 10-JUN-2026, entry version 20.
DE SubName: Full=GLIS family zinc finger 1 {ECO:0000313|Ensembl:ENSCCEP00000008570.1};
GN Name=GLIS1 {ECO:0000313|Ensembl:ENSCCEP00000008570.1};
OS Cyanistes caeruleus (Eurasian blue tit) (Parus caeruleus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Neoaves; Telluraves; Australaves;
OC Passeriformes; Paridae; Cyanistes.
OX NCBI_TaxID=156563 {ECO:0000313|Ensembl:ENSCCEP00000008570.1, ECO:0000313|Proteomes:UP000694410};
RN [1] {ECO:0000313|Ensembl:ENSCCEP00000008570.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (JAN-2026) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the GLI C2H2-type zinc-finger protein family.
CC {ECO:0000256|ARBA:ARBA00010831}.
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DR Ensembl; ENSCCET00000013654.1; ENSCCEP00000008570.1; ENSCCEG00000008837.1.
DR Proteomes; UP000694410; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:TreeGrafter.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IEA:TreeGrafter.
DR GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006351; P:DNA-templated transcription; IEA:UniProtKB-KW.
DR FunFam; 3.30.160.60:FF:000019; GLI family zinc finger 3; 1.
DR FunFam; 3.30.160.60:FF:000031; GLI family zinc finger 3; 1.
DR FunFam; 3.30.160.60:FF:000036; GLI family zinc finger 3; 1.
DR FunFam; 3.30.160.60:FF:000048; GLI family zinc finger 3; 1.
DR FunFam; 3.30.160.60:FF:000453; GLIS family zinc finger 3; 1.
DR Gene3D; 3.30.160.60; Classic Zinc Finger; 5.
DR InterPro; IPR043359; GLI-like.
DR InterPro; IPR048420; Zap1-like_Znf1.
DR InterPro; IPR056436; Znf-C2H2_ZIC1-5/GLI1-3-like.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR PANTHER; PTHR45718; TRANSCRIPTIONAL ACTIVATOR CUBITUS INTERRUPTUS; 1.
DR PANTHER; PTHR45718:SF3; ZINC FINGER PROTEIN GLIS1; 1.
DR Pfam; PF21816; Zap1_zf1; 1.
DR Pfam; PF00096; zf-C2H2; 3.
DR Pfam; PF23561; zf-C2H2_15; 1.
DR SMART; SM00355; ZnF_C2H2; 5.
DR SUPFAM; SSF57667; beta-beta-alpha zinc fingers; 3.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 4.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 5.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000694410};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Repressor {ECO:0000256|ARBA:ARBA00022491};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00042}.
FT DOMAIN 501..531
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 535..567
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 568..597
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 598..627
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 628..657
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT REGION 1..43
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 65..88
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 95..114
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 376..398
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 437..497
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 706..756
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 777..820
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 23..33
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 95..112
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 385..398
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 437..453
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 479..488
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 709..718
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 783..810
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 811..820
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 919 AA; 100802 MW; 05AAA116DEF56014 CRC64;
MPAPCSAMRS RTEPAGVPRC QTPRGGXRVP PGAGERRGPW QQPQADMHCE LAAPQKGSAR
VEVSDKCHGA PQKDLPRVTR PGAGKAHLNP QMSFKVSVSN GSDHTEPQQS PPEMSAPLLD
FIPKRPSIFE RIPILPRAQE LRCARGSKDY FQQQKHQSVK VNGGYNHCSL ISEKKNMVDM
EMTSSSVPVC RQGLFLHTGN SLMRDHALSR ERLLHVGQLN LAHSDLRSPR FQDSVDSAAP
CLNGSHPAQH IKQECPSDYK VLSEASTHRR ITEGMELRAS GSLHPELDLM NNSFTNSLSS
YLFNNEHSSS LGPLSLGTPQ HSARLQTSNL KKRCISVVPS SAEGIDITAI IRTSQTSLVT
CVNGLRTNSA GISSHPVEIS HHSAQKSSQP QSCSQPGNPC SIPSPPACLV PLSTECDRGD
CEQIQMQQAE ENGSLSLMMN GTSLPHQNSS HGTQKGLPPP YHLHQQLSQT PGTLPHLNAS
MSPKSLQPSD GDEQDLSSGK QVCQWIDCSA TYDQQDELVR HIEKTHIDQR KGEDFTCFWA
GCVRRYKPFN ARYKLLIHMR VHSGEKPNKC MFEGCNKAFS RLENLKIHLR SHTGEKPYLC
QHPGCQKAFS NSSDRAKHQR THLDTKPYAC QIPGCSKRYT DPSSLRKHVK AHSAKEQQVR
KKLKSCTDIE QDVLSECLAI QQLHTSSQHI LDGKCGRSVG PHDLITGMYS GSSTNHNGPS
PAVLPPPHDI PSRHLPLDSA LASPHHHQSP LESARDGLAP NIISPLVSPL KALVPPSLLQ
KHGSPSSHSQ SPNGQQFSGI PNTPYTPFPN QSVQQGSQGY QGSFHSIQNC FHYGDCYRTM
DQSVSSDVLT GESHCFNPLR QNGYHILNAP LASTGYEGIS EAQCVSEDMV SNGTDENGFF
QNSAFDHCLN HIPSIYTDT
//
