ID A0A8C0VD01_CYACU Unreviewed; 467 AA.
AC A0A8C0VD01;
DT 19-JAN-2022, integrated into UniProtKB/TrEMBL.
DT 19-JAN-2022, sequence version 1.
DT 28-JAN-2026, entry version 19.
DE RecName: Full=Forkhead box protein N3 {ECO:0000256|ARBA:ARBA00034870};
GN Name=FOXN3 {ECO:0000313|Ensembl:ENSCCEP00000020098.1};
OS Cyanistes caeruleus (Eurasian blue tit) (Parus caeruleus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Neoaves; Telluraves; Australaves;
OC Passeriformes; Paridae; Cyanistes.
OX NCBI_TaxID=156563 {ECO:0000313|Ensembl:ENSCCEP00000020098.1, ECO:0000313|Proteomes:UP000694410};
RN [1] {ECO:0000313|Ensembl:ENSCCEP00000020098.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (AUG-2025) to UniProtKB.
RN [2] {ECO:0000313|Ensembl:ENSCCEP00000020098.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2025) to UniProtKB.
CC -!- FUNCTION: Acts as a transcriptional repressor. May be involved in DNA
CC damage-inducible cell cycle arrests (checkpoints).
CC {ECO:0000256|ARBA:ARBA00034657}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|PROSITE-ProRule:PRU00089}.
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DR RefSeq; XP_023783493.1; XM_023927725.1.
DR AlphaFoldDB; A0A8C0VD01; -.
DR Ensembl; ENSCCET00000030498.1; ENSCCEP00000020098.1; ENSCCEG00000018224.1.
DR GeneID; 111929909; -.
DR CTD; 1112; -.
DR Proteomes; UP000694410; Unplaced.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0000987; F:cis-regulatory region sequence-specific DNA binding; IEA:TreeGrafter.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR CDD; cd20059; FH_FOXN3; 1.
DR FunFam; 1.10.10.10:FF:000167; forkhead box protein N3 isoform X1; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR047404; FH_FOXN3.
DR InterPro; IPR001766; Fork_head_dom.
DR InterPro; IPR047119; FOXN2/3-like.
DR InterPro; IPR018122; TF_fork_head_CS_1.
DR InterPro; IPR030456; TF_fork_head_CS_2.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR13962:SF20; FORKHEAD BOX PROTEIN N3; 1.
DR PANTHER; PTHR13962; FORKHEAD BOX PROTEIN N3-LIKE PROTEIN-RELATED; 1.
DR Pfam; PF00250; Forkhead; 1.
DR PRINTS; PR00053; FORKHEAD.
DR SMART; SM00339; FH; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS00657; FORK_HEAD_1; 1.
DR PROSITE; PS00658; FORK_HEAD_2; 1.
DR PROSITE; PS50039; FORK_HEAD_3; 1.
PE 4: Predicted;
KW Cell cycle {ECO:0000256|ARBA:ARBA00023306};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW ProRule:PRU00089};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW ProRule:PRU00089}; Reference proteome {ECO:0000313|Proteomes:UP000694410};
KW Repressor {ECO:0000256|ARBA:ARBA00022491};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 114..201
FT /note="Fork-head"
FT /evidence="ECO:0000259|PROSITE:PS50039"
FT DNA_BIND 114..201
FT /note="Fork-head"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00089"
FT REGION 1..37
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 294..436
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 27..36
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 316..325
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 326..340
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 348..362
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 364..386
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 394..406
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 467 AA; 51691 MW; 896E3A92B41C1513 CRC64;
MGPVMPPSKK PEGSGISVPS GLSQRYQDSD LSKALHDDED LDFSLPAIRL DKGAMEDEEL
TNLNWLHESK NLLKSFGDSV LRSVSPVQDI GDDTPPSPAH SDMPYDAKQN PNCKPPYSFS
CLIFMAIEDS PTKRLPVKDI YNWILEHFPY FANAPTGWKN SVRHNLSLNK CFKKVDKDRS
QSIGKGSLWC IDPEYRQNLI QALKKTPYHP YSHVFNTPPT SPQAYQSTSG PPIWPGSTFF
KRNGALLQVP SGVIQNGARV LSRGIFPGAR PLPINPIESM AVAVRNGITN CRMRTESEQS
CGSPVVSGDP KEDHNYSSAK SSNHRSTSPA SDSVSSSSAD DQYEFATKGS QDSSEGSEVS
FQSHESHSET EEEDKKQSRK ETKDSLADSG YASQHKKRQH LMKAKKVPSD TLPLKKRRTE
KPPESDDEEM KEAAGSLLHL AGIRSCLNNI TNRTAKGQKE QKETTKN
//
