ID   A0A8C0ZD69_CYACU        Unreviewed;       535 AA.
AC   A0A8C0ZD69;
DT   19-JAN-2022, integrated into UniProtKB/TrEMBL.
DT   19-JAN-2022, sequence version 1.
DT   28-JAN-2026, entry version 20.
DE   SubName: Full=Suppressor of cytokine signaling 5 {ECO:0000313|Ensembl:ENSCCEP00000012114.1};
GN   Name=SOCS5 {ECO:0000313|Ensembl:ENSCCEP00000012114.1};
OS   Cyanistes caeruleus (Eurasian blue tit) (Parus caeruleus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Neoaves; Telluraves; Australaves;
OC   Passeriformes; Paridae; Cyanistes.
OX   NCBI_TaxID=156563 {ECO:0000313|Ensembl:ENSCCEP00000012114.1, ECO:0000313|Proteomes:UP000694410};
RN   [1] {ECO:0000313|Ensembl:ENSCCEP00000012114.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (AUG-2025) to UniProtKB.
RN   [2] {ECO:0000313|Ensembl:ENSCCEP00000012114.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2025) to UniProtKB.
CC   -!- PATHWAY: Protein modification; protein ubiquitination.
CC       {ECO:0000256|ARBA:ARBA00004906}.
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DR   RefSeq; XP_023780279.1; XM_023924511.1.
DR   AlphaFoldDB; A0A8C0ZD69; -.
DR   Ensembl; ENSCCET00000018868.1; ENSCCEP00000012114.1; ENSCCEG00000011719.1.
DR   GeneID; 111927609; -.
DR   KEGG; ccae:111927609; -.
DR   CTD; 9655; -.
DR   OrthoDB; 8820570at2759; -.
DR   UniPathway; UPA00143; -.
DR   Proteomes; UP000694410; Unplaced.
DR   GO; GO:0005942; C:phosphatidylinositol 3-kinase complex; IEA:TreeGrafter.
DR   GO; GO:0046935; F:1-phosphatidylinositol-3-kinase regulator activity; IEA:TreeGrafter.
DR   GO; GO:0007259; P:cell surface receptor signaling pathway via JAK-STAT; IEA:InterPro.
DR   GO; GO:0007173; P:epidermal growth factor receptor signaling pathway; IEA:InterPro.
DR   GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR   GO; GO:0009968; P:negative regulation of signal transduction; IEA:UniProtKB-KW.
DR   GO; GO:0046854; P:phosphatidylinositol phosphate biosynthetic process; IEA:TreeGrafter.
DR   GO; GO:0032436; P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process; IEA:InterPro.
DR   GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR   CDD; cd03739; SOCS_SOCS5; 1.
DR   FunFam; 3.30.505.10:FF:000028; Suppressor of cytokine signaling 5; 1.
DR   Gene3D; 3.30.505.10; SH2 domain; 1.
DR   InterPro; IPR000980; SH2.
DR   InterPro; IPR036860; SH2_dom_sf.
DR   InterPro; IPR022252; SOCS4/SOCS5_dom.
DR   InterPro; IPR037343; SOCS5_SOCS.
DR   InterPro; IPR001496; SOCS_box.
DR   InterPro; IPR036036; SOCS_box-like_dom_sf.
DR   PANTHER; PTHR10155; PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT; 1.
DR   PANTHER; PTHR10155:SF15; SUPPRESSOR OF CYTOKINE SIGNALING 5; 1.
DR   Pfam; PF00017; SH2; 1.
DR   Pfam; PF12610; SOCS; 1.
DR   Pfam; PF07525; SOCS_box; 1.
DR   SMART; SM00252; SH2; 1.
DR   SMART; SM00253; SOCS; 1.
DR   SMART; SM00969; SOCS_box; 1.
DR   SUPFAM; SSF55550; SH2 domain; 1.
DR   SUPFAM; SSF158235; SOCS box-like; 1.
DR   PROSITE; PS50001; SH2; 1.
DR   PROSITE; PS50225; SOCS; 1.
PE   4: Predicted;
KW   Growth regulation {ECO:0000256|ARBA:ARBA00022604};
KW   Reference proteome {ECO:0000313|Proteomes:UP000694410};
KW   SH2 domain {ECO:0000256|ARBA:ARBA00022999, ECO:0000256|PROSITE-
KW   ProRule:PRU00191};
KW   Signal transduction inhibitor {ECO:0000256|ARBA:ARBA00022700};
KW   Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786}.
FT   DOMAIN          380..475
FT                   /note="SH2"
FT                   /evidence="ECO:0000259|PROSITE:PS50001"
FT   DOMAIN          470..519
FT                   /note="SOCS box"
FT                   /evidence="ECO:0000259|PROSITE:PS50225"
FT   REGION          115..139
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   535 AA;  61302 MW;  3803EEAC56BF3029 CRC64;
     MDKVGKMWNN FKYRCQNLFS HEGGSQNESI VVNSSNCSSD KDKAIQITDL TQQPSSPLRE
     NIALQLGLSP SKNSARRNQN CVTEIPQIVE ISIEKENDSC VTTGARLARR DSYSRHAPWG
     GKKKHSCSTK TQSSLDTEKR FGRARSGLQR RERRYGVSSV HDMDAVSSRT VGSRSLRQRL
     QDTVGLCFPM RTYSKQTKPL FSNKRKIHLS ELMLEKCPFP AGSDLAQKWH LIKQHTAPVS
     PHSTFFDTFD PSLVSTEDEE DRLRERRRLS IEEGVDPPPN AQIHTFEATA QVNPLYKLGP
     KLAPGMTELT GDKTITPPGN CDSEEDTTTL CLQSRRQKQR QMSGENHSHI SRQGAWKVHT
     QIDYIHCLVP DLLQITGNPC YWGVMDRYEA EALLEGKPEG TFLLRDSAQE DYLFSVSFRR
     YNRSLHARIE QWNHNFSFDA HDPCVFHSST VTGLLEHYKD PSSCMFFEPL LTVSLNRTFP
     FSLQYICRAV ICRCTTYDGI DDLPLPSMLQ DFLKEYHYKQ KVRVRWLERE PIKTK
//