ID A0A8C1CM19_CYPCA Unreviewed; 537 AA.
AC A0A8C1CM19;
DT 19-JAN-2022, integrated into UniProtKB/TrEMBL.
DT 28-JUN-2023, sequence version 2.
DT 28-JAN-2026, entry version 19.
DE RecName: Full=BBSome complex member BBS5 {ECO:0000256|ARBA:ARBA00047191};
OS Cyprinus carpio carpio.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Cyprinidae; Cyprininae; Cyprinus.
OX NCBI_TaxID=630221 {ECO:0000313|Ensembl:ENSCCRP00000050154.2, ECO:0000313|Proteomes:UP001108240};
RN [1] {ECO:0000313|Ensembl:ENSCCRP00000050154.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (AUG-2025) to UniProtKB.
RN [2] {ECO:0000313|Ensembl:ENSCCRP00000050154.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2025) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell projection, cilium membrane
CC {ECO:0000256|ARBA:ARBA00004309}. Cytoplasm, cytoskeleton, microtubule
CC organizing center, centrosome, centriolar satellite
CC {ECO:0000256|ARBA:ARBA00004607}.
CC -!- SIMILARITY: Belongs to the BBS5 family.
CC {ECO:0000256|ARBA:ARBA00005822}.
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DR AlphaFoldDB; A0A8C1CM19; -.
DR Ensembl; ENSCCRT00000054332.2; ENSCCRP00000050154.2; ENSCCRG00000026620.2.
DR GeneTree; ENSGT00940000158859; -.
DR Proteomes; UP001108240; Unplaced.
DR GO; GO:0034464; C:BBSome; IEA:InterPro.
DR GO; GO:0034451; C:centriolar satellite; IEA:UniProtKB-SubCell.
DR GO; GO:0036064; C:ciliary basal body; IEA:TreeGrafter.
DR GO; GO:0060170; C:ciliary membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0032266; F:phosphatidylinositol-3-phosphate binding; IEA:TreeGrafter.
DR GO; GO:0060271; P:cilium assembly; IEA:TreeGrafter.
DR CDD; cd00900; PH-like; 1.
DR FunFam; 2.30.29.30:FF:000232; Bardet-Biedl syndrome 5 isoform 1; 1.
DR Gene3D; 2.120.10.80; Kelch-type beta propeller; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR006606; BBL5.
DR InterPro; IPR014003; BBS5_PH.
DR InterPro; IPR015915; Kelch-typ_b-propeller.
DR InterPro; IPR006652; Kelch_1.
DR InterPro; IPR011993; PH-like_dom_sf.
DR PANTHER; PTHR21351:SF0; BARDET-BIEDL SYNDROME 5 PROTEIN; 1.
DR PANTHER; PTHR21351; BARDET-BIEDL SYNDROME PROTEIN 5; 1.
DR Pfam; PF07289; BBL5; 1.
DR Pfam; PF24681; Kelch_KLHDC2_KLHL20_DRC7; 1.
DR SMART; SM00683; DM16; 2.
DR SMART; SM00612; Kelch; 3.
DR SUPFAM; SSF117281; Kelch motif; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Cilium {ECO:0000256|ARBA:ARBA00023069};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Kelch repeat {ECO:0000256|ARBA:ARBA00022441};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Reference proteome {ECO:0000313|Proteomes:UP001108240}.
FT DOMAIN 29..83
FT /note="BBSome complex member BBS5 PH"
FT /evidence="ECO:0000259|SMART:SM00683"
FT DOMAIN 159..213
FT /note="BBSome complex member BBS5 PH"
FT /evidence="ECO:0000259|SMART:SM00683"
SQ SEQUENCE 537 AA; 60790 MW; A7BA59AC6B988798 CRC64;
MASVLDALWE DRDVRFDITQ QQMKTRPGEA LIDCLDSIED TKGNNGDRGR LLVTNLRIIW
HSLALPRVNL SVGYNCIINI TTRTANSKLR GQTEALYVLT KSNNTRFEFI FTNVVPGSPR
LFTSVIAVHR AYETSKMYRD LKLRGALIQN KQLRLLPQEQ VYDKINGVWN LSSDQGNLGT
FFITNVRIVW HANMNESFNV SIPYLQIRSI RIRDSKFGLA LVIESSQQTG GYVLGFKIDP
MDKLQDAVKE INSLHKVYSA NPIFGVEYEM EEKPQPLEEL TVEQLPDDVE IEPDEHTDAF
TLDTHSPNWI ALPPMPSPRC LFTMGEFENL LFAVAGKDLQ TNESLDSVLC YDVDKMKWQE
TKKLPLRIHG HSAISQNGLV YCIGGKTDEN KTIDKMFAYN HKKSEWKELA AMKTPRSMFG
AVLHKGKIIV VGGVNEDGLL DSCEAYDFGT NKWEPFAEFV QERSSVNLVS AAGVLYAVGG
FAMQENEDKQ CVPSEITDIW QYEEDKKQWT GMIQEMRYAA GASCVSMRLN AAKMPKL
//
