ID A0A8C1I600_CYPCA Unreviewed; 463 AA.
AC A0A8C1I600;
DT 19-JAN-2022, integrated into UniProtKB/TrEMBL.
DT 19-JAN-2022, sequence version 1.
DT 28-JAN-2026, entry version 15.
DE RecName: Full=Ethanolamine kinase {ECO:0000256|ARBA:ARBA00081737};
DE EC=2.7.1.32 {ECO:0000256|ARBA:ARBA00066350};
DE EC=2.7.1.82 {ECO:0000256|ARBA:ARBA00038874};
OS Cyprinus carpio (Common carp).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Cyprinidae; Cyprininae; Cyprinus.
OX NCBI_TaxID=7962 {ECO:0000313|Ensembl:ENSCCRP00010002010.1, ECO:0000313|Proteomes:UP000694427};
RN [1] {ECO:0000313|Ensembl:ENSCCRP00010002010.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (AUG-2025) to UniProtKB.
RN [2] {ECO:0000313|Ensembl:ENSCCRP00010002010.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2025) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=choline + ATP = phosphocholine + ADP + H(+);
CC Xref=Rhea:RHEA:12837, ChEBI:CHEBI:15354, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:295975, ChEBI:CHEBI:456216;
CC EC=2.7.1.32; Evidence={ECO:0000256|ARBA:ARBA00052454};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:12838;
CC Evidence={ECO:0000256|ARBA:ARBA00052454};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ethanolamine + ATP = phosphoethanolamine + ADP + H(+);
CC Xref=Rhea:RHEA:13069, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:57603, ChEBI:CHEBI:58190, ChEBI:CHEBI:456216;
CC EC=2.7.1.82; Evidence={ECO:0000256|ARBA:ARBA00050770};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:13070;
CC Evidence={ECO:0000256|ARBA:ARBA00050770};
CC -!- PATHWAY: Lipid metabolism. {ECO:0000256|ARBA:ARBA00005189}.
CC -!- PATHWAY: Phospholipid metabolism; phosphatidylethanolamine
CC biosynthesis; phosphatidylethanolamine from ethanolamine: step 1/3.
CC {ECO:0000256|ARBA:ARBA00037883}.
CC -!- SIMILARITY: Belongs to the choline/ethanolamine kinase family.
CC {ECO:0000256|ARBA:ARBA00038211}.
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DR AlphaFoldDB; A0A8C1I600; -.
DR Ensembl; ENSCCRT00010002186.1; ENSCCRP00010002010.1; ENSCCRG00010000893.1.
DR Proteomes; UP000694427; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:TreeGrafter.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004103; F:choline kinase activity; IEA:UniProtKB-EC.
DR GO; GO:0004305; F:ethanolamine kinase activity; IEA:UniProtKB-EC.
DR GO; GO:0006646; P:phosphatidylethanolamine biosynthetic process; IEA:TreeGrafter.
DR CDD; cd05156; ChoK_euk; 1.
DR FunFam; 3.90.1200.10:FF:000005; Choline kinase alpha; 1.
DR Gene3D; 3.90.1200.10; -; 1.
DR Gene3D; 3.30.200.20; Phosphorylase Kinase, domain 1; 1.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR PANTHER; PTHR22603:SF101; CHOLINE KINASE BETA; 1.
DR PANTHER; PTHR22603; CHOLINE/ETHANOALAMINE KINASE; 1.
DR Pfam; PF01633; Choline_kinase; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
PE 3: Inferred from homology;
KW Acetylation {ECO:0000256|ARBA:ARBA00022990};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Kinase {ECO:0000256|ARBA:ARBA00022777};
KW Lipid biosynthesis {ECO:0000256|ARBA:ARBA00022516};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00023098};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Phospholipid biosynthesis {ECO:0000256|ARBA:ARBA00023209};
KW Phospholipid metabolism {ECO:0000256|ARBA:ARBA00023264};
KW Reference proteome {ECO:0000313|Proteomes:UP000694427};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT REGION 59..102
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 91..102
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 463 AA; 53193 MW; ECDB290588038787 CRC64;
MLLLGRIGVI TYSGSVLSLS LRSIGFLARK IMNSSQRAKC MSDGAGSVGR CVEDDAVSDR
PAGGDSLMAA EERHPRSASP RGVNGEDDSE AESHQDGRNV DVDPETRRRA FSWCRDFLSG
SWKAISEHDF QISIVSGGLS NLLYMCSLPD DVQPTGVEPR RVLLRIYGAI LQGVDSLVLE
SVMFAILAER ELGPHLYGIF PEGRLEQYLP SNRLCTEQLG FPEISAEIAS KMARFHRMEM
PFNKEPKWLF ATIDRYMEQV KTIKFVREAH IKKFTKLKKY DLPAELENLR SLLAATPSPV
VFCHNDVQEG NILMLDGREN SSDKLMLIDF EYSSYNYRGF DFGNHFCEWI YDYTYNQWPF
YKAKVENYPN RQQQLRFIRH YLSEKGGIAP ADQARIEEDM IIEANRFALA SHFLWGLWSI
IQAKISKIEF GYMVNKFFFK KYQYTQTNYN PCKHFYNPSM MIF
//
