ID A0A8C2WKV2_CYCLU Unreviewed; 237 AA.
AC A0A8C2WKV2;
DT 19-JAN-2022, integrated into UniProtKB/TrEMBL.
DT 19-JAN-2022, sequence version 1.
DT 28-JAN-2026, entry version 19.
DE RecName: Full=Insulin-like growth factor-binding protein 1 {ECO:0000256|ARBA:ARBA00013675};
GN Name=LOC117746281 {ECO:0000313|Ensembl:ENSCLMP00005003083.1};
OS Cyclopterus lumpus (Lumpsucker).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Perciformes; Cottioidei; Cottales; Cyclopteridae; Cyclopterus.
OX NCBI_TaxID=8103 {ECO:0000313|Ensembl:ENSCLMP00005003083.1, ECO:0000313|Proteomes:UP000694565};
RN [1] {ECO:0000313|Ensembl:ENSCLMP00005003083.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (AUG-2025) to UniProtKB.
RN [2] {ECO:0000313|Ensembl:ENSCLMP00005003083.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2025) to UniProtKB.
CC -!- FUNCTION: IGF-binding proteins prolong the half-life of the IGFs and
CC have been shown to either inhibit or stimulate the growth promoting
CC effects of the IGFs on cell culture. They alter the interaction of IGFs
CC with their cell surface receptors. {ECO:0000256|ARBA:ARBA00003811}.
CC -!- SUBUNIT: Binds equally well IGF1 and IGF2. Interacts with integrin
CC ITGA5:ITGB1. Interacts with VHL; this interaction inhibits HIF1A
CC degradation. {ECO:0000256|ARBA:ARBA00049694}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00500}.
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DR AlphaFoldDB; A0A8C2WKV2; -.
DR Ensembl; ENSCLMT00005003411.1; ENSCLMP00005003083.1; ENSCLMG00005001769.1.
DR GeneTree; ENSGT00940000157394; -.
DR Proteomes; UP000694565; Unplaced.
DR GO; GO:0005615; C:extracellular space; IEA:TreeGrafter.
DR GO; GO:0031994; F:insulin-like growth factor I binding; IEA:TreeGrafter.
DR GO; GO:0031995; F:insulin-like growth factor II binding; IEA:TreeGrafter.
DR GO; GO:0048640; P:negative regulation of developmental growth; IEA:UniProtKB-ARBA.
DR GO; GO:0043567; P:regulation of insulin-like growth factor receptor signaling pathway; IEA:TreeGrafter.
DR CDD; cd00191; TY; 1.
DR FunFam; 4.10.40.20:FF:000001; Insulin-like growth factor binding protein 5; 1.
DR FunFam; 4.10.800.10:FF:000002; Insulin-like growth factor-binding protein 2; 1.
DR Gene3D; 4.10.40.20; -; 1.
DR Gene3D; 4.10.800.10; Thyroglobulin type-1; 1.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR000867; IGFBP-like.
DR InterPro; IPR022322; IGFBP1.
DR InterPro; IPR022321; IGFBP_1-6_chordata.
DR InterPro; IPR017891; Insulin_GF-bd_Cys-rich_CS.
DR InterPro; IPR000716; Thyroglobulin_1.
DR InterPro; IPR036857; Thyroglobulin_1_sf.
DR PANTHER; PTHR11551; INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN; 1.
DR PANTHER; PTHR11551:SF28; INSULIN-LIKE GROWTH FACTOR-BINDING PROTEIN 1; 1.
DR Pfam; PF00219; IGFBP; 1.
DR Pfam; PF00086; Thyroglobulin_1; 1.
DR PRINTS; PR01976; IGFBPFAMILY.
DR PRINTS; PR01977; IGFBPFAMILY1.
DR SMART; SM00121; IB; 1.
DR SMART; SM00211; TY; 1.
DR SUPFAM; SSF57184; Growth factor receptor domain; 1.
DR SUPFAM; SSF57610; Thyroglobulin type-1 domain; 1.
DR PROSITE; PS00222; IGFBP_N_1; 1.
DR PROSITE; PS51323; IGFBP_N_2; 1.
DR PROSITE; PS00484; THYROGLOBULIN_1_1; 1.
DR PROSITE; PS51162; THYROGLOBULIN_1_2; 1.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Growth factor binding {ECO:0000256|ARBA:ARBA00023183};
KW Growth regulation {ECO:0000256|ARBA:ARBA00022604};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000694565};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}.
FT DOMAIN 25..106
FT /note="IGFBP N-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51323"
FT DOMAIN 153..231
FT /note="Thyroglobulin type-1"
FT /evidence="ECO:0000259|PROSITE:PS51162"
SQ SEQUENCE 237 AA; 25507 MW; 0FFD552059CAA300 CRC64;
QVINYTAAAL AVLASVRSSP VVEPEPIRCA ACTQETLDGC PAVPPDCAQV LREPGCGCCM
ACALEKGASC GVHTAHCGGG LRCIPRPGEA RPLHALTRGQ GVCSEDQEEA VPDQASLHYL
LGLNLPLDPE DPTEGQESIR TKINAIRNKL MQEGPCHVEL HAAVDTISSS QQKLREKFTT
FYLPNCDKRG YYQAKQCESS LVGPPARCWC VSPWNGKKLP GSSDLRSDSE CHQEVTH
//
