ID A0A8C3C6R2_CAIMO Unreviewed; 1045 AA.
AC A0A8C3C6R2;
DT 19-JAN-2022, integrated into UniProtKB/TrEMBL.
DT 19-JAN-2022, sequence version 1.
DT 28-JAN-2026, entry version 19.
DE SubName: Full=Multiple EGF like domains 11 {ECO:0000313|Ensembl:ENSCMMP00000015990.1};
OS Cairina moschata (Muscovy duck).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Anseriformes; Anatidae;
OC Anatinae; Cairina.
OX NCBI_TaxID=8855 {ECO:0000313|Ensembl:ENSCMMP00000015990.1, ECO:0000313|Proteomes:UP000694556};
RN [1] {ECO:0000313|Ensembl:ENSCMMP00000015990.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Vignal A., Thebault N., Warren W.C.;
RT "Common duck and Muscovy duck high density SNP chip.";
RL Submitted (SEP-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSCMMP00000015990.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (AUG-2025) to UniProtKB.
RN [3] {ECO:0000313|Ensembl:ENSCMMP00000015990.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2025) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004162};
CC Single-pass membrane protein {ECO:0000256|ARBA:ARBA00004162}.
CC -!- SIMILARITY: Belongs to the MEGF family.
CC {ECO:0000256|ARBA:ARBA00038377}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR AlphaFoldDB; A0A8C3C6R2; -.
DR Ensembl; ENSCMMT00000017574.1; ENSCMMP00000015990.1; ENSCMMG00000009695.1.
DR Proteomes; UP000694556; Chromosome 11.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR FunFam; 2.170.300.10:FF:000007; multiple epidermal growth factor-like domains protein 10; 1.
DR FunFam; 2.10.25.10:FF:000114; Multiple epidermal growth factor-like domains protein 11; 1.
DR FunFam; 2.170.300.10:FF:000005; multiple epidermal growth factor-like domains protein 11; 1.
DR FunFam; 2.170.300.10:FF:000006; Multiple epidermal growth factor-like domains protein 11; 1.
DR FunFam; 2.170.300.10:FF:000021; Platelet endothelial aggregation receptor 1; 1.
DR FunFam; 2.170.300.10:FF:000041; Tyrosine protein kinase receptor tie-1, putative; 1.
DR Gene3D; 2.10.25.10; Laminin; 1.
DR Gene3D; 2.170.300.10; Tie2 ligand-binding domain superfamily; 5.
DR InterPro; IPR000742; EGF.
DR InterPro; IPR013032; EGF-like_CS.
DR InterPro; IPR057138; EGF_PEAR1L-like.
DR InterPro; IPR011489; EMI_domain.
DR InterPro; IPR002049; LE_dom.
DR InterPro; IPR052485; MEGF_diff_regulators.
DR PANTHER; PTHR24052; DELTA-RELATED; 1.
DR PANTHER; PTHR24052:SF13; MULTIPLE EGF LIKE DOMAINS 11; 1.
DR Pfam; PF00053; EGF_laminin; 3.
DR Pfam; PF23301; EGF_PEAR1L; 1.
DR Pfam; PF23106; EGF_Teneurin; 1.
DR Pfam; PF12661; hEGF; 6.
DR PRINTS; PR00011; EGFLAMININ.
DR SMART; SM00181; EGF; 16.
DR SMART; SM00180; EGF_Lam; 14.
DR PROSITE; PS00022; EGF_1; 13.
DR PROSITE; PS01186; EGF_2; 2.
DR PROSITE; PS50026; EGF_3; 7.
DR PROSITE; PS50027; EGF_LAM_2; 1.
DR PROSITE; PS51041; EMI; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Laminin EGF-like domain {ECO:0000256|PROSITE-ProRule:PRU00460};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000694556};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..20
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 21..1045
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5034249366"
FT TRANSMEM 808..831
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1..86
FT /note="EMI"
FT /evidence="ECO:0000259|PROSITE:PS51041"
FT DOMAIN 128..158
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 166..201
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 269..304
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 358..393
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 444..479
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 530..565
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 709..739
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 712..753
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DISULFID 148..157
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 191..200
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 294..303
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 383..392
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 469..478
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 555..564
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 729..738
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 1045 AA; 113723 MW; D293D9ED67D9AB00 CRC64;
TRPKLFMLHL SLSFFAPSYA VTVQESYAHP FDQIYYTRCT DILNWFKCTR HRISYKTAYR
RGLRTMYRRR SQCCPGYYES GDYCIPLCTE ECVHGRCVSP DTCHCEPGWG GTDCSSGCDS
DHWGPHCSNR CQCQNEALCN PITGACVCAD GYQGWRCEEL CDPGSYGKGC QFQCQCHNGA
TCDHETGECH CAPGYTGVFC EERCPPGSHG AQCELRCPCQ NGGVCHHITG ECSCPPGWMV
RRLFMLIHHL ELGGLVCAQC QEECPIGTYG FQCTQRCDCQ NGAKCYHVNG ACMCDPGFKG
IHCQERMCPE GLYGLKCNKR CPCNITNTLS CHPLSGECSC KAGWAGLYCN ETCPPGYYGE
GCQLTCSCQN GADCDSITGK CTCAPGYMGD DCTITCMEGT YGTNCSSVCN CKNDGTCSPV
DGLCICKEGW QGMDCSIPCS SGSWGLNCNQ TCYCTNGAAC RPADGFCLCS PGWQGEYCDQ
PCPDGTYGLN CSERCDCSHA DGCDPVTGYC CCLAGWTGIH CDNICSQGRW GPNCSISCNC
ENGGSCSPED GTCDCAPGYR GPLCQRICPP GFHGHHCSQP CPQCVHSSGP CHHVSGHCDC
LPGFFGALCN QVCPSGKYGK NCDEVCQCTE NGTCNPIDGS CQCFPGWIGK DCSQTCPTGF
WGPDCFHSCN CHNGAMCSPY DGECRCTHGW TGLYCTQRCP TAFYGKNCAN VCQCQNGADC
DHITGQCTCR TGFTGKQCEQ KCSPGTFGYG CKQLCECMNN ATCDHVTGTC YCSPGFKGIR
CDQAALMMEE LNPYTKISPA LGSERHSVGA IIGIIILLLI IMVLLALFVW YRRKQKEKGH
DMPSVSYTPA MRMTNTDYSL SDISQGSGSV HCFSNPSYHT LSCGVTSRFF TSNVDGNSSS
KVDIIPSHSN SPTPSCFADY MKESVCSSST CSLNSSENPY ATIKDPPILT CKHSESSYVE
MKSPGHRESP YSEMPTSSTA NKNIYEVEPT VSVVQDARGR SASYLQNPYD LPRNSHIPSH
YDLLPVRHSP TKREDNPFLC CRMLT
//
