ID   A0A8C3J5I1_9CHAR        Unreviewed;       545 AA.
AC   A0A8C3J5I1;
DT   19-JAN-2022, integrated into UniProtKB/TrEMBL.
DT   19-JAN-2022, sequence version 1.
DT   28-JAN-2026, entry version 21.
DE   SubName: Full=Suppressor of cytokine signaling 5 {ECO:0000313|Ensembl:ENSCPGP00000002694.1};
OS   Calidris pygmaea (Spoon-billed sandpiper).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Neoaves; Charadriiformes; Scolopacidae;
OC   Calidris.
OX   NCBI_TaxID=425635 {ECO:0000313|Ensembl:ENSCPGP00000002694.1, ECO:0000313|Proteomes:UP000694419};
RN   [1] {ECO:0000313|Ensembl:ENSCPGP00000002694.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (MAY-2025) to UniProtKB.
CC   -!- PATHWAY: Protein modification; protein ubiquitination.
CC       {ECO:0000256|ARBA:ARBA00004906}.
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DR   AlphaFoldDB; A0A8C3J5I1; -.
DR   Ensembl; ENSCPGT00000002960.1; ENSCPGP00000002679.1; ENSCPGG00000001993.1.
DR   Ensembl; ENSCPGT00000002973.1; ENSCPGP00000002694.1; ENSCPGG00000001993.1.
DR   UniPathway; UPA00143; -.
DR   Proteomes; UP000694419; Unplaced.
DR   GO; GO:0005942; C:phosphatidylinositol 3-kinase complex; IEA:TreeGrafter.
DR   GO; GO:0046935; F:1-phosphatidylinositol-3-kinase regulator activity; IEA:TreeGrafter.
DR   GO; GO:0007259; P:cell surface receptor signaling pathway via JAK-STAT; IEA:InterPro.
DR   GO; GO:0007173; P:epidermal growth factor receptor signaling pathway; IEA:InterPro.
DR   GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR   GO; GO:0009968; P:negative regulation of signal transduction; IEA:UniProtKB-KW.
DR   GO; GO:0046854; P:phosphatidylinositol phosphate biosynthetic process; IEA:TreeGrafter.
DR   GO; GO:0032436; P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process; IEA:InterPro.
DR   GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR   CDD; cd03739; SOCS_SOCS5; 1.
DR   FunFam; 3.30.505.10:FF:000028; Suppressor of cytokine signaling 5; 1.
DR   Gene3D; 3.30.505.10; SH2 domain; 1.
DR   InterPro; IPR000980; SH2.
DR   InterPro; IPR036860; SH2_dom_sf.
DR   InterPro; IPR022252; SOCS4/SOCS5_dom.
DR   InterPro; IPR037343; SOCS5_SOCS.
DR   InterPro; IPR001496; SOCS_box.
DR   InterPro; IPR036036; SOCS_box-like_dom_sf.
DR   PANTHER; PTHR10155; PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT; 1.
DR   PANTHER; PTHR10155:SF15; SUPPRESSOR OF CYTOKINE SIGNALING 5; 1.
DR   Pfam; PF00017; SH2; 1.
DR   Pfam; PF12610; SOCS; 1.
DR   Pfam; PF07525; SOCS_box; 1.
DR   SMART; SM00252; SH2; 1.
DR   SMART; SM00253; SOCS; 1.
DR   SMART; SM00969; SOCS_box; 1.
DR   SUPFAM; SSF55550; SH2 domain; 1.
DR   SUPFAM; SSF158235; SOCS box-like; 1.
DR   PROSITE; PS50001; SH2; 1.
DR   PROSITE; PS50225; SOCS; 1.
PE   4: Predicted;
KW   Growth regulation {ECO:0000256|ARBA:ARBA00022604};
KW   Reference proteome {ECO:0000313|Proteomes:UP000694419};
KW   SH2 domain {ECO:0000256|ARBA:ARBA00022999, ECO:0000256|PROSITE-
KW   ProRule:PRU00191};
KW   Signal transduction inhibitor {ECO:0000256|ARBA:ARBA00022700};
KW   Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786}.
FT   DOMAIN          390..485
FT                   /note="SH2"
FT                   /evidence="ECO:0000259|PROSITE:PS50001"
FT   DOMAIN          480..529
FT                   /note="SOCS box"
FT                   /evidence="ECO:0000259|PROSITE:PS50225"
FT   REGION          124..158
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   545 AA;  62485 MW;  A9025CAC2CFDFE5C CRC64;
     MLFWITYSMD KVGKMWNNFK YRCQNLFSHE GGSQNENVVV NSSSCSSAKE KAIQITDLAQ
     RQPSSPLREN IALQLGLSPS KNSARRNQNC VTEIPQIVEI SIEKENDSCV TTGARLARRD
     SYSRHAPWGG KKKHSCSTKT QSSLDTEKRF GRTRSGLQRR ERRYGVSSVH DMDAVSNRTV
     GSRSLRQRLQ DTVGLCFPMR TYSSKQSKPL FSNKRKIHLS ELMLEKCPFP AGSDLAQKWH
     LIKQHTAPVS PHSTFFDTFD PSLVSTEDEE DRLRERRRLS IEEGVDPPPN AQIHTFEATA
     QVNPLYKLGP KLAPGMTELT GDKNLTPPGN CDSEEDSTTL CLQSRRQKQR QMSGESHGHI
     SRQGAWKVHT QIDYIHCLVP DLLQITGNPC YWGVMDRYEA EALLEGKPEG TFLLRDSAQE
     DYLFSVSFRR YNRSLHARIE QWNHNFSFDA HDPCVFHSST VTGLLEHYKD PSSCMFFEPL
     LTVSLNRTFP FSLQYICRAV ICRCTTYDGI DDLPLPSMLQ DFLKEYHYKQ KVRVRWLERE
     PIKSK
//