ID A0A8C3NLC7_GEOPR Unreviewed; 470 AA.
AC A0A8C3NLC7;
DT 19-JAN-2022, integrated into UniProtKB/TrEMBL.
DT 19-JAN-2022, sequence version 1.
DT 28-JAN-2026, entry version 20.
DE RecName: Full=TNF receptor-associated factor {ECO:0000256|PIRNR:PIRNR015614};
GN Name=TRAF4 {ECO:0000313|Ensembl:ENSCPVP00000019733.1};
OS Geospiza parvula (Small tree-finch) (Camarhynchus parvulus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Neoaves; Telluraves; Australaves;
OC Passeriformes; Thraupidae; Camarhynchus.
OX NCBI_TaxID=87175 {ECO:0000313|Ensembl:ENSCPVP00000019733.1, ECO:0000313|Proteomes:UP000694382};
RN [1] {ECO:0000313|Ensembl:ENSCPVP00000019733.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Enbody D E., Pettersson E M.;
RL Submitted (FEB-2020) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSCPVP00000019733.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (AUG-2025) to UniProtKB.
RN [3] {ECO:0000313|Ensembl:ENSCPVP00000019733.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2025) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine +
CC [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-
CC cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.;
CC EC=2.3.2.27; Evidence={ECO:0000256|ARBA:ARBA00000900};
CC -!- PATHWAY: Protein degradation; proteasomal ubiquitin-dependent pathway.
CC {ECO:0000256|ARBA:ARBA00060618}.
CC -!- SUBUNIT: Homotrimer. Interacts with LTBR/TNFRSF3, NGFR/TNFRSF16,
CC RPS6KB1 and TGFB1I1. Interacts with SMURF1. Interacts (via TRAF domain)
CC with MAP3K4 (via kinase domain). Interacts with NCF1, TICAM1, IRAK1 and
CC TRAF6, and is probably part of a complex containing TRAF4, NCF1,
CC TICAM1, IRAK1 and TRAF6. Interacts (via MATH domain) with GP6 and
CC GP1BB. Interacts with EGFR (via C-terminal region); this interaction
CC promotes the formation of EGFR asymmetric dimers. Interacts with PKM;
CC this interaction promotes PKM kinase activity.
CC {ECO:0000256|ARBA:ARBA00062519}.
CC -!- SUBCELLULAR LOCATION: Cell junction, tight junction
CC {ECO:0000256|ARBA:ARBA00004435}. Cell membrane
CC {ECO:0000256|ARBA:ARBA00004413}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004413}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004413}. Cytoplasm, cytoskeleton
CC {ECO:0000256|ARBA:ARBA00004245}. Cytoplasm, perinuclear region
CC {ECO:0000256|ARBA:ARBA00004556}. Nucleus
CC {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the TNF receptor-associated factor family. B
CC subfamily. {ECO:0000256|ARBA:ARBA00061230}.
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DR RefSeq; XP_030818426.1; XM_030962566.1.
DR AlphaFoldDB; A0A8C3NLC7; -.
DR Ensembl; ENSCPVT00000020618.2; ENSCPVP00000019733.1; ENSCPVG00000014366.2.
DR GeneID; 115911527; -.
DR CTD; 9618; -.
DR Proteomes; UP000694382; Chromosome 19.
DR GO; GO:0005923; C:bicellular tight junction; IEA:UniProtKB-SubCell.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005164; F:tumor necrosis factor receptor binding; IEA:UniProtKB-UniRule.
DR GO; GO:0061630; F:ubiquitin protein ligase activity; IEA:UniProtKB-EC.
DR GO; GO:0031625; F:ubiquitin protein ligase binding; IEA:TreeGrafter.
DR GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR GO; GO:0046330; P:positive regulation of JNK cascade; IEA:InterPro.
DR GO; GO:0042981; P:regulation of apoptotic process; IEA:InterPro.
DR GO; GO:0043122; P:regulation of canonical NF-kappaB signal transduction; IEA:TreeGrafter.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd03781; MATH_TRAF4; 1.
DR CDD; cd16641; mRING-HC-C3HC3D_TRAF4; 1.
DR FunFam; 2.60.210.10:FF:000007; TNF receptor-associated factor; 1.
DR FunFam; 3.30.40.10:FF:000381; TNF receptor-associated factor; 1.
DR FunFam; 3.30.40.10:FF:000508; TNF receptor-associated factor; 1.
DR FunFam; 3.30.40.10:FF:000610; TNF receptor-associated factor; 1.
DR FunFam; 3.30.40.10:FF:000649; TNF receptor-associated factor; 1.
DR Gene3D; 2.60.210.10; Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2, Chain A; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 4.
DR InterPro; IPR002083; MATH/TRAF_dom.
DR InterPro; IPR012227; TNF_rcpt-assoc_TRAF_met.
DR InterPro; IPR008974; TRAF-like.
DR InterPro; IPR049342; TRAF1-6_MATH_dom.
DR InterPro; IPR037307; TRAF4_MATH.
DR InterPro; IPR018957; Znf_C3HC4_RING-type.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR InterPro; IPR017907; Znf_RING_CS.
DR InterPro; IPR001293; Znf_TRAF.
DR PANTHER; PTHR10131; TNF RECEPTOR ASSOCIATED FACTOR; 1.
DR PANTHER; PTHR10131:SF94; TNF RECEPTOR-ASSOCIATED FACTOR 4; 1.
DR Pfam; PF21355; TRAF-mep_MATH; 1.
DR Pfam; PF00097; zf-C3HC4; 1.
DR Pfam; PF02176; zf-TRAF; 2.
DR PIRSF; PIRSF015614; TRAF; 1.
DR SMART; SM00061; MATH; 1.
DR SMART; SM00184; RING; 1.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR SUPFAM; SSF49599; TRAF domain-like; 4.
DR PROSITE; PS50144; MATH; 1.
DR PROSITE; PS00518; ZF_RING_1; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
DR PROSITE; PS50145; ZF_TRAF; 3.
PE 3: Inferred from homology;
KW Apoptosis {ECO:0000256|ARBA:ARBA00022703};
KW Cell junction {ECO:0000256|ARBA:ARBA00022949};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490, ECO:0000256|PIRNR:PIRNR015614};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW Immunity {ECO:0000256|ARBA:ARBA00022859};
KW Innate immunity {ECO:0000256|ARBA:ARBA00022588};
KW Isopeptide bond {ECO:0000256|ARBA:ARBA00022499};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|PIRNR:PIRNR015614}; Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000694382};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Tight junction {ECO:0000256|ARBA:ARBA00022427};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Ubl conjugation {ECO:0000256|ARBA:ARBA00022843};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786};
KW Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|PIRNR:PIRNR015614};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
SQ SEQUENCE 470 AA; 53686 MW; E008FE3CA10CA94B CRC64;
MPGYDYKLLE RPRRRVLCPL CGKPMREPVR VSTCGHRFCD TCLQEFLSEG VFKCPEDQLP
LDYAKIYPDP ELEAQVLSLA IRCIHSEEGC RWSGLIKHLQ AHLGTCGFNV IPCPNRCSAK
LSRRDLPEHV QHGCPKRRVK CEFCASDFTG EAFEGHQGTC PQESVYCENK CGARMMRRLL
SQHALAECPK RTQPCTYCSK EFVFDTIQNH QYQCPRYPVP CPNQCGTPSI AREDVPTHLK
ESCNTAMLLC PFKEAGCKHR CPKLAMGRHL EESTKTHLGM VCALVSRQRQ EILELRRDVE
ELSVSSDGTL IWKIADYARK LQEAKARSNY EFFSPPFYTH KYGYKLQVSA FLNGNGSGES
SHLSVYIRVL PGEYDNLLEW PFSYRVTFSL LDQSDPSLSK PQHITETFHP DPNWKNFQKP
GASRSSLDES TLGFGYPKFI SHEDIRKRNY VRDNAIFIKA SVEIPQKILA
//
