ID   A0A8C3W6T9_9CETA        Unreviewed;       193 AA.
AC   A0A8C3W6T9;
DT   19-JAN-2022, integrated into UniProtKB/TrEMBL.
DT   19-JAN-2022, sequence version 1.
DT   28-JAN-2026, entry version 19.
DE   RecName: Full=Reticulon {ECO:0000256|RuleBase:RU210713};
GN   Name=RTN1 {ECO:0000313|Ensembl:ENSCWAP00000006763.1};
OS   Catagonus wagneri (Chacoan peccary).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Suina; Tayassuidae; Catagonus.
OX   NCBI_TaxID=51154 {ECO:0000313|Ensembl:ENSCWAP00000006763.1, ECO:0000313|Proteomes:UP000694540};
RN   [1] {ECO:0000313|Ensembl:ENSCWAP00000006763.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (AUG-2025) to UniProtKB.
RN   [2] {ECO:0000313|Ensembl:ENSCWAP00000006763.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2025) to UniProtKB.
CC   -!- FUNCTION: Inhibits amyloid precursor protein processing, probably by
CC       blocking BACE1 activity. {ECO:0000256|ARBA:ARBA00037306}.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC       {ECO:0000256|ARBA:ARBA00004477, ECO:0000256|RuleBase:RU210713}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004477,
CC       ECO:0000256|RuleBase:RU210713}.
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DR   AlphaFoldDB; A0A8C3W6T9; -.
DR   Ensembl; ENSCWAT00000007340.1; ENSCWAP00000006763.1; ENSCWAG00000004885.1.
DR   GeneTree; ENSGT00940000155077; -.
DR   Proteomes; UP000694540; Unplaced.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0043005; C:neuron projection; IEA:TreeGrafter.
DR   GO; GO:0014069; C:postsynaptic density; IEA:TreeGrafter.
DR   GO; GO:0007420; P:brain development; IEA:TreeGrafter.
DR   GO; GO:0071787; P:endoplasmic reticulum tubular network formation; IEA:TreeGrafter.
DR   GO; GO:0030182; P:neuron differentiation; IEA:TreeGrafter.
DR   FunFam; 1.20.5.2480:FF:000001; Reticulon; 1.
DR   Gene3D; 1.20.5.2480; -; 1.
DR   InterPro; IPR003388; Reticulon.
DR   InterPro; IPR046964; RTN1-4.
DR   PANTHER; PTHR45799:SF5; RETICULON-1; 1.
DR   PANTHER; PTHR45799; RETICULON-LIKE PROTEIN; 1.
DR   Pfam; PF02453; Reticulon; 1.
DR   PROSITE; PS50845; RETICULON; 1.
PE   4: Predicted;
KW   Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824,
KW   ECO:0000256|RuleBase:RU210713};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU210713};
KW   Reference proteome {ECO:0000313|Proteomes:UP000694540};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU210713};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|RuleBase:RU210713}.
FT   TRANSMEM        20..49
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU210713"
FT   TRANSMEM        135..157
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU210713"
FT   DOMAIN          6..193
FT                   /note="Reticulon"
FT                   /evidence="ECO:0000259|PROSITE:PS50845"
SQ   SEQUENCE   193 AA;  21834 MW;  C58FB3B905CD828F CRC64;
     TLFLTAIDLL YWRDIKQTGI VFGSFLLLLF SLTQFSVVSV VAYLALAALS ATISFRIYKS
     VLQAVQKTDE GHPFKAYLEL EITLSQEQIQ KYTDCLQFYV NSTLKELRRL FLVQDLVDSL
     KFAVLMWLLT YVGAIFNGLT LLLVAVVSMF TLPVVYVKHQ AQIDQYLGLV RTHINAIVAK
     IQAKIPGAKR HAE
//