ID A0A8C4H5F7_DICLA Unreviewed; 530 AA.
AC A0A8C4H5F7;
DT 19-JAN-2022, integrated into UniProtKB/TrEMBL.
DT 12-OCT-2022, sequence version 2.
DT 28-JAN-2026, entry version 20.
DE RecName: Full=Uridine-cytidine kinase {ECO:0000256|RuleBase:RU003825};
DE EC=2.7.1.48 {ECO:0000256|RuleBase:RU003825};
GN Name=si:ch211-243j20.2 {ECO:0000313|Ensembl:ENSDLAP00005037437.2};
OS Dicentrarchus labrax (European seabass) (Morone labrax).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Moronidae; Dicentrarchus.
OX NCBI_TaxID=13489 {ECO:0000313|Ensembl:ENSDLAP00005037437.2, ECO:0000313|Proteomes:UP000694389};
RN [1] {ECO:0000313|Ensembl:ENSDLAP00005037437.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (AUG-2025) to UniProtKB.
RN [2] {ECO:0000313|Ensembl:ENSDLAP00005037437.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2025) to UniProtKB.
CC -!- FUNCTION: May contribute to UTP accumulation needed for blast
CC transformation and proliferation. {ECO:0000256|ARBA:ARBA00056790}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=cytidine + ATP = CMP + ADP + H(+); Xref=Rhea:RHEA:24674,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:17562, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:60377, ChEBI:CHEBI:456216; EC=2.7.1.48;
CC Evidence={ECO:0000256|ARBA:ARBA00047436,
CC ECO:0000256|RuleBase:RU003825};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=uridine + ATP = UMP + ADP + H(+); Xref=Rhea:RHEA:16825,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:16704, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:57865, ChEBI:CHEBI:456216; EC=2.7.1.48;
CC Evidence={ECO:0000256|ARBA:ARBA00048909,
CC ECO:0000256|RuleBase:RU003825};
CC -!- PATHWAY: Pyrimidine metabolism; CTP biosynthesis via salvage pathway;
CC CTP from cytidine: step 1/3. {ECO:0000256|RuleBase:RU003825}.
CC -!- PATHWAY: Pyrimidine metabolism; UMP biosynthesis via salvage pathway;
CC UMP from uridine: step 1/1. {ECO:0000256|ARBA:ARBA00004690,
CC ECO:0000256|RuleBase:RU003825}.
CC -!- SUBUNIT: Interacts with RNF19B. {ECO:0000256|ARBA:ARBA00065923}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the uridine kinase family.
CC {ECO:0000256|ARBA:ARBA00005408, ECO:0000256|RuleBase:RU003825}.
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DR AlphaFoldDB; A0A8C4H5F7; -.
DR Ensembl; ENSDLAT00005039954.2; ENSDLAP00005037437.2; ENSDLAG00005016520.2.
DR GeneTree; ENSGT01020000230412; -.
DR UniPathway; UPA00574; UER00637.
DR UniPathway; UPA00579; UER00640.
DR Proteomes; UP000694389; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004849; F:uridine kinase activity; IEA:UniProtKB-EC.
DR GO; GO:0044211; P:CTP salvage; IEA:UniProtKB-UniPathway.
DR GO; GO:0044206; P:UMP salvage; IEA:UniProtKB-UniPathway.
DR CDD; cd06223; PRTases_typeI; 1.
DR CDD; cd02023; UMPK; 1.
DR FunFam; 3.40.50.2020:FF:000010; Uridine-cytidine kinase; 1.
DR FunFam; 3.40.50.300:FF:000200; Uridine-cytidine kinase; 1.
DR Gene3D; 3.40.50.2020; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR006083; PRK/URK.
DR InterPro; IPR029057; PRTase-like.
DR InterPro; IPR000836; PRTase_dom.
DR InterPro; IPR000764; Uridine_kinase-like.
DR NCBIfam; NF001097; PRK00129.1; 1.
DR NCBIfam; NF004018; PRK05480.1; 1.
DR NCBIfam; TIGR00235; udk; 1.
DR PANTHER; PTHR10285; URIDINE KINASE; 1.
DR Pfam; PF00485; PRK; 1.
DR Pfam; PF14681; UPRTase; 1.
DR PRINTS; PR00988; URIDINKINASE.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF53271; PRTase-like; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU003825};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000256|RuleBase:RU003825};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU003825}; Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000694389};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU003825};
KW Ubl conjugation {ECO:0000256|ARBA:ARBA00022843}.
FT DOMAIN 76..263
FT /note="Phosphoribulokinase/uridine kinase"
FT /evidence="ECO:0000259|Pfam:PF00485"
FT DOMAIN 312..515
FT /note="Phosphoribosyltransferase"
FT /evidence="ECO:0000259|Pfam:PF14681"
FT REGION 1..50
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 29..43
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 530 AA; 59451 MW; 22D4EAC230051573 CRC64;
NHTDSRDLTS GDDSLDGLSN RVPRCPLTPS LSPQKRTTSQ SKTEPPLLRT DKRTIYTAGR
PPWYNVTGTT FKEAFVIGLC GGSASGKTTV ANKIIEALDV PWVVLLSMDS FYKVLNKEEQ
ELAAKNEYNF DHPDAFDFEL LVTVLRKLKK GKSIKVPVYD FTSHCRRKEW KTVYGANVVI
FEGILAFANK ELLKLLDMKV FVDTDSDIRL IRRLKRDISQ RGRDISGIIK QYNKFVKPAF
EQYIEPTVQS ADIVVPRGGE NFVALDLIVQ HVHSQLEKVR VPRPVSVSVR ESALASAHQG
QPLPKTLSVM ESTPQVRGMH TIIRNKETNR DEFIFYSKRL MRLLIEHALS FLPLKPVSVE
TPQGGVYDGK RLSGKRITGV SILRAGETME QALMAVCKDI RLGKILIQTN HDTGEPELHY
LRLPKDISED YVILMDSTVS TGAAALMAVR VLLDHDVAED KIFLLSLLMA EMGVHSVAYA
FPKVRIITTA VDKEVNDQFH IIPGIGNFGD RYFGTDAPSD WCESDEGMDF
//
