ID A0A8C4LQZ7_EQUAS Unreviewed; 712 AA.
AC A0A8C4LQZ7;
DT 19-JAN-2022, integrated into UniProtKB/TrEMBL.
DT 19-JAN-2022, sequence version 1.
DT 28-JAN-2026, entry version 20.
DE RecName: Full=Zinc finger protein 750 {ECO:0000256|ARBA:ARBA00040216};
GN Name=ZNF750 {ECO:0000313|Ensembl:ENSEASP00005012313.1};
OS Equus asinus (Donkey) (Equus africanus asinus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX NCBI_TaxID=9793 {ECO:0000313|Ensembl:ENSEASP00005012313.1, ECO:0000313|Proteomes:UP000694387};
RN [1] {ECO:0000313|Ensembl:ENSEASP00005012313.1, ECO:0000313|Proteomes:UP000694387}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=33293529;
RA Wang, C., Li, H., Guo, Y., Huang, J., Sun, Y., Min, J., Wang, J., Fang, X.,
RA Zhao, Z., Wang, S., Zhang, Y., Liu, Q., Jiang, Q., Wang, X., Guo, Y., Yang,
RA C., Wang, Y., Tian, F., Zhuang, G., Fan, Y., Gao, Q., Li, Y., Ju, Z., Li,
RA J., Li, R., Hou, M., Yang, G., Liu, G., Liu, W., Guo, J., Pan, S., Fan, G.,
RA Zhang, W., Zhang, R., Yu, J., Zhang, X., Yin, Q., Ji, C., Jin, Y., Yue, G.,
RA Liu, M., Xu, J., Liu, S., Jordana, J., Noce, A., Amills, M., Wu, D.D., Li,
RA S., Zhou, X. and Zhong, J.;
RT "Donkey genomes provide new insights into domestication and selection for
RT coat color.";
RL Nat. Commun. 11:6014-6014(2020).
RN [2] {ECO:0000313|Ensembl:ENSEASP00005012313.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (AUG-2025) to UniProtKB.
RN [3] {ECO:0000313|Ensembl:ENSEASP00005012313.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2025) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR RefSeq; XP_014720533.1; XM_014865047.3.
DR AlphaFoldDB; A0A8C4LQZ7; -.
DR Ensembl; ENSEAST00005013374.2; ENSEASP00005012313.1; ENSEASG00005008591.2.
DR GeneID; 106846320; -.
DR KEGG; eai:106846320; -.
DR CTD; 79755; -.
DR GeneTree; ENSGT00530000063870; -.
DR OMA; PSAYDHY; -.
DR OrthoDB; 8933073at2759; -.
DR Proteomes; UP000694387; Chromosome 13.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IEA:Ensembl.
DR GO; GO:0001227; F:DNA-binding transcription repressor activity, RNA polymerase II-specific; IEA:Ensembl.
DR GO; GO:1990841; F:promoter-specific chromatin binding; IEA:Ensembl.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IEA:Ensembl.
DR GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-KW.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR GO; GO:0061436; P:establishment of skin barrier; IEA:Ensembl.
DR GO; GO:0044091; P:membrane biogenesis; IEA:Ensembl.
DR GO; GO:0010719; P:negative regulation of epithelial to mesenchymal transition; IEA:Ensembl.
DR GO; GO:2000304; P:positive regulation of ceramide biosynthetic process; IEA:Ensembl.
DR GO; GO:0010628; P:positive regulation of gene expression; IEA:Ensembl.
DR InterPro; IPR039363; ZNF750.
DR InterPro; IPR039064; ZNF750_Znf.
DR PANTHER; PTHR14678; PROLINE-RICH PROTEIN 35-RELATED; 1.
DR PANTHER; PTHR14678:SF1; ZINC FINGER PROTEIN 750; 1.
DR Pfam; PF15269; zf-C2H2_7; 1.
PE 4: Predicted;
KW Activator {ECO:0000256|ARBA:ARBA00023159};
KW Differentiation {ECO:0000256|ARBA:ARBA00022782};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000694387};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT DOMAIN 6..57
FT /note="Zinc finger protein 750-like zinc finger"
FT /evidence="ECO:0000259|Pfam:PF15269"
FT REGION 62..93
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 354..425
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 439..531
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 543..622
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 635..712
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 67..93
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 355..364
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 370..394
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 413..423
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 457..474
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 478..490
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 560..572
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 581..592
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 597..606
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 647..667
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 712 AA; 76802 MW; 621C2CCF162EAADF CRC64;
MSLLKERKPK KPHYIPRPPG KPFKYKCFQC PFTCNEKSHL FNHMKYGLCK NSITLVSEQD
RVPKCPKSNS LDSKQTSQLD PVAKPTSSKS VTSGLSHFDA KLQHSKDAKE NVDLHTCGSH
TCPGQKPALL KEAVPLSPEA TMGTQPALEG VVRPSAFVPV GEQRLKGPEH VEPPAVLPLP
TPSTKATSFH TKSAFHAPGY PWRAGSPFLP PEFPHKVPPT KGFGAVSPYM HPTIPDYPPH
FYTEHGLATV YSPYLLAGNS PECDATLLAV YGAQDHRRFL PHPGPIPKHL SPSPSTYDHY
RFFQQHHSNL PIPYGFYRPE SAFSSYGLRL PPVAGISQDQ SSHLLEEAAL VYPASSPSKL
NPPNSHRKHT EFEKESPTPE AKDPSKDGQR DTEGTKMSPR AGSAATGSPG RPSPTNFTQT
SQPCAGLCSL SDKLASSSLG RLHQPEQSLA AFKPIKRSPE RPHSQAPENR DEAPKSLNAV
NTDATAQTGS ACHGLEAAPC SPEDGSRMAP LNLSKKPETR PAAAHDPVYE DFTELQDMPL
NLSVKDPCNA LTPRPSFHSP PQEAEPATAA PKTEPESSGD GPDHTETKRN SLDSDEAPST
SPTGKAQGSR GAADSSDEQK QTAAVALCQL AAYSPGNVRV GDGEPTAQGS ACQQRSPTLS
ATGSQEAQCD LRPKGQKRTS PRDAGKSQQG TKKTKPSDTA RVFTLRKRTR LS
//
