ID A0A8C4PGN7_EQUAS Unreviewed; 441 AA.
AC A0A8C4PGN7;
DT 19-JAN-2022, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2023, sequence version 2.
DT 28-JAN-2026, entry version 20.
DE SubName: Full=Suppressor of cytokine signaling 4 {ECO:0000313|Ensembl:ENSEASP00005004138.2};
GN Name=SOCS4 {ECO:0000313|Ensembl:ENSEASP00005004138.2};
OS Equus asinus (Donkey) (Equus africanus asinus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX NCBI_TaxID=9793 {ECO:0000313|Ensembl:ENSEASP00005004138.2, ECO:0000313|Proteomes:UP000694387};
RN [1] {ECO:0000313|Ensembl:ENSEASP00005004138.2, ECO:0000313|Proteomes:UP000694387}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=33293529;
RA Wang, C., Li, H., Guo, Y., Huang, J., Sun, Y., Min, J., Wang, J., Fang, X.,
RA Zhao, Z., Wang, S., Zhang, Y., Liu, Q., Jiang, Q., Wang, X., Guo, Y., Yang,
RA C., Wang, Y., Tian, F., Zhuang, G., Fan, Y., Gao, Q., Li, Y., Ju, Z., Li,
RA J., Li, R., Hou, M., Yang, G., Liu, G., Liu, W., Guo, J., Pan, S., Fan, G.,
RA Zhang, W., Zhang, R., Yu, J., Zhang, X., Yin, Q., Ji, C., Jin, Y., Yue, G.,
RA Liu, M., Xu, J., Liu, S., Jordana, J., Noce, A., Amills, M., Wu, D.D., Li,
RA S., Zhou, X. and Zhong, J.;
RT "Donkey genomes provide new insights into domestication and selection for
RT coat color.";
RL Nat. Commun. 11:6014-6014(2020).
RN [2] {ECO:0000313|Ensembl:ENSEASP00005004138.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (MAY-2025) to UniProtKB.
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC {ECO:0000256|ARBA:ARBA00004906}.
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DR AlphaFoldDB; A0A8C4PGN7; -.
DR Ensembl; ENSEAST00005004538.2; ENSEASP00005004138.2; ENSEASG00005003134.2.
DR Ensembl; ENSEAST00005061950.1; ENSEASP00005061795.1; ENSEASG00005003134.2.
DR GeneID; 106846111; -.
DR KEGG; eai:106846111; -.
DR CTD; 122809; -.
DR GeneTree; ENSGT00940000161456; -.
DR UniPathway; UPA00143; -.
DR Proteomes; UP000694387; Chromosome 7.
DR GO; GO:0005942; C:phosphatidylinositol 3-kinase complex; IEA:TreeGrafter.
DR GO; GO:0046935; F:1-phosphatidylinositol-3-kinase regulator activity; IEA:TreeGrafter.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR GO; GO:0009968; P:negative regulation of signal transduction; IEA:UniProtKB-KW.
DR GO; GO:0046854; P:phosphatidylinositol phosphate biosynthetic process; IEA:TreeGrafter.
DR GO; GO:0032436; P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process; IEA:InterPro.
DR GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR CDD; cd10385; SH2_SOCS4; 1.
DR CDD; cd03738; SOCS_SOCS4; 1.
DR FunFam; 3.30.505.10:FF:000028; Suppressor of cytokine signaling 5; 1.
DR Gene3D; 3.30.505.10; SH2 domain; 1.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR022252; SOCS4/SOCS5_dom.
DR InterPro; IPR035864; SOCS4_SH2.
DR InterPro; IPR037342; SOCS4_SOCS.
DR InterPro; IPR001496; SOCS_box.
DR InterPro; IPR036036; SOCS_box-like_dom_sf.
DR PANTHER; PTHR10155; PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT; 1.
DR PANTHER; PTHR10155:SF21; SUPPRESSOR OF CYTOKINE SIGNALING 4; 1.
DR Pfam; PF00017; SH2; 1.
DR Pfam; PF12610; SOCS; 1.
DR Pfam; PF07525; SOCS_box; 1.
DR SMART; SM00252; SH2; 1.
DR SMART; SM00253; SOCS; 1.
DR SMART; SM00969; SOCS_box; 1.
DR SUPFAM; SSF55550; SH2 domain; 1.
DR SUPFAM; SSF158235; SOCS box-like; 1.
DR PROSITE; PS50001; SH2; 1.
DR PROSITE; PS50225; SOCS; 1.
PE 4: Predicted;
KW Growth regulation {ECO:0000256|ARBA:ARBA00022604};
KW Reference proteome {ECO:0000313|Proteomes:UP000694387};
KW SH2 domain {ECO:0000256|ARBA:ARBA00022999, ECO:0000256|PROSITE-
KW ProRule:PRU00191};
KW Signal transduction inhibitor {ECO:0000256|ARBA:ARBA00022700};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786}.
FT DOMAIN 287..382
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT DOMAIN 377..426
FT /note="SOCS box"
FT /evidence="ECO:0000259|PROSITE:PS50225"
FT REGION 1..29
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..11
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 12..29
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 441 AA; 50586 MW; 7CB2326B34B39D92 CRC64;
MAENSENNSK NLDVRPKTSR SRSADRKDGY VWSGKKLSWS KKSESCSDAE TVNSIEKTEV
PLRSQERKHS CSSIELDLDH SCGHRFLGRS LKQKLQDAMG QCFPIKNCSS RHPSGLSSKR
KIHISELMLD KCPFPPRSDL AFRWHFIKRH TAPINPESDE WVSRDLSQSE LRDGQLKQRR
TAEEEVNCFP HTIVQPCVIT TNNASCRGGP MTGSVMNLVS NNSIEDSDMD SDDEIVTLCT
SSRKRNKPKW ETDEEILQLE TPPKYHTQID YVHCLVPDLL QINNNPCYWG VMDKYAAEAL
LEGKPEGTFL LRDSAQEDYL FSVSFRRYSR SLHARIEQWN HNFSFDAHDP CVFHSPDITG
LLEHYKDPSA CMFFEPLLST PLIRTFPFSL QHICRTVICN CTTYDGIDAL PVPSAMKLYL
KEYHYKSKVR VLRIDAPEQQ C
//
