ID A0A8C4UWL2_FALTI Unreviewed; 365 AA.
AC A0A8C4UWL2;
DT 19-JAN-2022, integrated into UniProtKB/TrEMBL.
DT 19-JAN-2022, sequence version 1.
DT 28-JAN-2026, entry version 17.
DE SubName: Full=Insulin like growth factor binding protein 2 {ECO:0000313|Ensembl:ENSFTIP00000017648.1};
OS Falco tinnunculus (Common kestrel).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Neoaves; Telluraves; Australaves;
OC Falconiformes; Falconidae; Falco.
OX NCBI_TaxID=100819 {ECO:0000313|Ensembl:ENSFTIP00000017648.1, ECO:0000313|Proteomes:UP000694562};
RN [1] {ECO:0000313|Ensembl:ENSFTIP00000017648.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (AUG-2025) to UniProtKB.
RN [2] {ECO:0000313|Ensembl:ENSFTIP00000017648.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2025) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00500}.
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DR AlphaFoldDB; A0A8C4UWL2; -.
DR Ensembl; ENSFTIT00000018388.1; ENSFTIP00000017648.1; ENSFTIG00000011687.1.
DR OMA; NLMPITM; -.
DR OrthoDB; 9984807at2759; -.
DR Proteomes; UP000694562; Unplaced.
DR GO; GO:0005615; C:extracellular space; IEA:TreeGrafter.
DR GO; GO:0031994; F:insulin-like growth factor I binding; IEA:TreeGrafter.
DR GO; GO:0031995; F:insulin-like growth factor II binding; IEA:TreeGrafter.
DR GO; GO:0043567; P:regulation of insulin-like growth factor receptor signaling pathway; IEA:TreeGrafter.
DR FunFam; 4.10.40.20:FF:000007; Insulin-like growth factor-binding protein 2; 1.
DR Gene3D; 4.10.40.20; -; 1.
DR Gene3D; 4.10.800.10; Thyroglobulin type-1; 1.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR012210; IGFBP-2.
DR InterPro; IPR000867; IGFBP-like.
DR InterPro; IPR022321; IGFBP_1-6_chordata.
DR InterPro; IPR017891; Insulin_GF-bd_Cys-rich_CS.
DR InterPro; IPR000716; Thyroglobulin_1.
DR InterPro; IPR036857; Thyroglobulin_1_sf.
DR PANTHER; PTHR11551; INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN; 1.
DR PANTHER; PTHR11551:SF5; INSULIN-LIKE GROWTH FACTOR-BINDING PROTEIN 2; 1.
DR Pfam; PF00219; IGFBP; 1.
DR Pfam; PF00086; Thyroglobulin_1; 1.
DR PRINTS; PR01976; IGFBPFAMILY.
DR PRINTS; PR01978; IGFBPFAMILY2.
DR SMART; SM00121; IB; 1.
DR SUPFAM; SSF57184; Growth factor receptor domain; 1.
DR SUPFAM; SSF57610; Thyroglobulin type-1 domain; 1.
DR PROSITE; PS00222; IGFBP_N_1; 1.
DR PROSITE; PS51323; IGFBP_N_2; 1.
DR PROSITE; PS51162; THYROGLOBULIN_1_2; 1.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Growth factor binding {ECO:0000256|ARBA:ARBA00023183};
KW Growth regulation {ECO:0000256|ARBA:ARBA00022604};
KW Reference proteome {ECO:0000313|Proteomes:UP000694562};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..31
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 32..365
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5034299596"
FT DOMAIN 38..120
FT /note="IGFBP N-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51323"
FT DOMAIN 209..309
FT /note="Thyroglobulin type-1"
FT /evidence="ECO:0000259|PROSITE:PS51162"
FT REGION 122..141
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 181..210
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 132..141
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 365 AA; 39021 MW; 22A86C6081E86A4A CRC64;
MALGAVGHGG AARAAWPRLL VAAAAAALAL AGPALPEVLF RCPPCTAERL AACPPAARPP
CPELVREPGC GCCPVCARLE AEACGVYTPR CAAGLRCYPD PGAELPLQAL VQGQGTCARR
RDTAEYGASA ERPADNGDDR SESILAENHV DGTTGILSGA GGRKPMKTGM KELAVMREKV
NEQQRQMGKV GKPHHNHEDS KKSRLSTGRT PCQQELDQVL ERISTMRLPD ERGPLEHLYS
LHIPNCDKHG LYNLKQCKMS VNGQRGECCP RAGGPGSTCP AEPVERRYPA HWRQLAVAPV
LDFTWVSACL FRLWKRLGLG PECCPPSPAA QLLGRGGILG GEGRWGVGGG VARRRDCFLI
VFHPV
//
