ID   A0A8C5MKR0_9ANUR        Unreviewed;       537 AA.
AC   A0A8C5MKR0;
DT   19-JAN-2022, integrated into UniProtKB/TrEMBL.
DT   19-JAN-2022, sequence version 1.
DT   28-JAN-2026, entry version 19.
DE   SubName: Full=Suppressor of cytokine signaling 5 {ECO:0000313|Ensembl:ENSLLEP00000015200.1};
GN   Name=SOCS5 {ECO:0000313|Ensembl:ENSLLEP00000015200.1};
OS   Leptobrachium leishanense (Leishan spiny toad).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pelobatoidea; Megophryidae; Leptobrachium.
OX   NCBI_TaxID=445787 {ECO:0000313|Ensembl:ENSLLEP00000015200.1, ECO:0000313|Proteomes:UP000694569};
RN   [1] {ECO:0000313|Ensembl:ENSLLEP00000015200.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (AUG-2025) to UniProtKB.
RN   [2] {ECO:0000313|Ensembl:ENSLLEP00000015200.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2025) to UniProtKB.
CC   -!- PATHWAY: Protein modification; protein ubiquitination.
CC       {ECO:0000256|ARBA:ARBA00004906}.
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DR   AlphaFoldDB; A0A8C5MKR0; -.
DR   Ensembl; ENSLLET00000015782.1; ENSLLEP00000015200.1; ENSLLEG00000009670.1.
DR   GeneTree; ENSGT00940000159000; -.
DR   OrthoDB; 8820570at2759; -.
DR   UniPathway; UPA00143; -.
DR   Proteomes; UP000694569; Unplaced.
DR   GO; GO:0005942; C:phosphatidylinositol 3-kinase complex; IEA:TreeGrafter.
DR   GO; GO:0046935; F:1-phosphatidylinositol-3-kinase regulator activity; IEA:TreeGrafter.
DR   GO; GO:0007259; P:cell surface receptor signaling pathway via JAK-STAT; IEA:InterPro.
DR   GO; GO:0007173; P:epidermal growth factor receptor signaling pathway; IEA:InterPro.
DR   GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR   GO; GO:0009968; P:negative regulation of signal transduction; IEA:UniProtKB-KW.
DR   GO; GO:0046854; P:phosphatidylinositol phosphate biosynthetic process; IEA:TreeGrafter.
DR   GO; GO:0032436; P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process; IEA:InterPro.
DR   GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR   CDD; cd03739; SOCS_SOCS5; 1.
DR   FunFam; 3.30.505.10:FF:000028; Suppressor of cytokine signaling 5; 1.
DR   Gene3D; 3.30.505.10; SH2 domain; 1.
DR   InterPro; IPR000980; SH2.
DR   InterPro; IPR036860; SH2_dom_sf.
DR   InterPro; IPR022252; SOCS4/SOCS5_dom.
DR   InterPro; IPR037343; SOCS5_SOCS.
DR   InterPro; IPR001496; SOCS_box.
DR   InterPro; IPR036036; SOCS_box-like_dom_sf.
DR   PANTHER; PTHR10155; PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT; 1.
DR   PANTHER; PTHR10155:SF15; SUPPRESSOR OF CYTOKINE SIGNALING 5; 1.
DR   Pfam; PF00017; SH2; 1.
DR   Pfam; PF12610; SOCS; 1.
DR   Pfam; PF07525; SOCS_box; 1.
DR   SMART; SM00252; SH2; 1.
DR   SMART; SM00253; SOCS; 1.
DR   SMART; SM00969; SOCS_box; 1.
DR   SUPFAM; SSF55550; SH2 domain; 1.
DR   SUPFAM; SSF158235; SOCS box-like; 1.
DR   PROSITE; PS50001; SH2; 1.
DR   PROSITE; PS50225; SOCS; 1.
PE   4: Predicted;
KW   Growth regulation {ECO:0000256|ARBA:ARBA00022604};
KW   Reference proteome {ECO:0000313|Proteomes:UP000694569};
KW   SH2 domain {ECO:0000256|ARBA:ARBA00022999, ECO:0000256|PROSITE-
KW   ProRule:PRU00191};
KW   Signal transduction inhibitor {ECO:0000256|ARBA:ARBA00022700};
KW   Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786}.
FT   DOMAIN          382..477
FT                   /note="SH2"
FT                   /evidence="ECO:0000259|PROSITE:PS50001"
FT   DOMAIN          472..521
FT                   /note="SOCS box"
FT                   /evidence="ECO:0000259|PROSITE:PS50225"
FT   REGION          117..161
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   537 AA;  61446 MW;  12B67473F6734412 CRC64;
     MDKVGKMWNN FKYRCQNLFS HDDDGPQTNI VDVNSNRCLG GSAKNDIASS HAHIQSIIPL
     QENTLPEMSF STFSNLSRRS QNCVTEIPQL VEISIEKEND LGLSVGTRLA RRDSYTRHAP
     WGGKKKHSCS TKTQNSFDPD KKINRTRNGL QRRERRHGVS SVHDVETVSI RAIGSRSLRQ
     RLNETVGLCF PIRTYNRPSK PLFTNKRKIH LSELMLEKCP FPAGSDLAQK WHLIKQHTAP
     VSPHANLLDT FEQSAISTED EEDRLRERRR LSIEEGVDPP PNAQIHTFEA TAQVNPVYKL
     GPKLAVGMAD MSGEGGTLSQ PGCESEEDTT TLCLQSRRQK QRQVSGDSHT QVNRQGAWKV
     HTQIDYIHCL VPDLIEITSN PCYWGVMDRY EAEALLEGKP EGTFLLRDSA QEDYLFSVSF
     RRYNRSLHAR IEQWNHNFSF DAHDPCVFHS STVTGLLEHY KDPSSCMFFE PLLTVPLNRT
     FPFSLQYICR AVICRSTTYD GIDALPLPSM LQDFLKEYHY KQKVRVRWLE REPLKSK
//