ID A0A8C5VJN8_MICMU Unreviewed; 427 AA.
AC A0A8C5VJN8;
DT 19-JAN-2022, integrated into UniProtKB/TrEMBL.
DT 19-JAN-2022, sequence version 1.
DT 28-JAN-2026, entry version 21.
DE RecName: Full=TNF receptor-associated factor {ECO:0000256|PIRNR:PIRNR015614};
GN Name=TRAF4 {ECO:0000313|Ensembl:ENSMICP00000021711.1};
OS Microcebus murinus (Gray mouse lemur) (Lemur murinus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lemuriformes;
OC Cheirogaleidae; Microcebus.
OX NCBI_TaxID=30608 {ECO:0000313|Ensembl:ENSMICP00000021711.1, ECO:0000313|Proteomes:UP000694394};
RN [1] {ECO:0000313|Ensembl:ENSMICP00000021711.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Harris R., Larsen P., Liu Y., Hughes D.S., Murali S., Raveendran M.,
RA Korchina V., Wang M., Jhangiani S., Bandaranaike D., Bellair M.,
RA Blankenburg K., Chao H., Dahdouli M., Dinh H., Doddapaneni H., English A.,
RA Firestine M., Gnanaolivu R., Gross S., Hernandez B., Javaid M.,
RA Jayaseelan J., Jones J., Khan Z., Kovar C., Kurapati P., Le B., Lee S.,
RA Li M., Mathew T., Narasimhan A., Ngo D., Nguyen L., Okwuonu G., Ongeri F.,
RA Osuji N., Pu L.-L., Puazo M., Quiroz J., Raj R., Rajbhandari K., Reid J.G.,
RA Santibanez J., Sexton D., Skinner E., Vee V., Weissenberger G., Wu Y.,
RA Xin Y., Han Y., Campbell C., Brown A., Sullivan B., Shelton J., Brown S.,
RA Dudchenko O., Machol I., Durand N., Shamim M., Lieberman A., Muzny D.M.,
RA Richards S., Yoder A., Worley K.C., Rogers J., Gibbs R.A.;
RT "Mouse lemur reference genome and diversity panel.";
RL Submitted (DEC-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSMICP00000021711.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (AUG-2025) to UniProtKB.
RN [3] {ECO:0000313|Ensembl:ENSMICP00000021711.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2025) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496,
CC ECO:0000256|PIRNR:PIRNR015614}.
CC -!- SIMILARITY: Belongs to the TNF receptor-associated factor family.
CC {ECO:0000256|PIRNR:PIRNR015614}.
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DR EMBL; ABDC03020328; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A8C5VJN8; -.
DR Ensembl; ENSMICT00000046744.2; ENSMICP00000021711.1; ENSMICG00000005338.3.
DR GeneTree; ENSGT00940000158628; -.
DR Proteomes; UP000694394; Chromosome 16.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005164; F:tumor necrosis factor receptor binding; IEA:UniProtKB-UniRule.
DR GO; GO:0031625; F:ubiquitin protein ligase binding; IEA:TreeGrafter.
DR GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0042981; P:regulation of apoptotic process; IEA:InterPro.
DR GO; GO:0043122; P:regulation of canonical NF-kappaB signal transduction; IEA:TreeGrafter.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd16641; mRING-HC-C3HC3D_TRAF4; 1.
DR FunFam; 3.30.40.10:FF:000381; TNF receptor-associated factor; 1.
DR FunFam; 3.30.40.10:FF:000508; TNF receptor-associated factor; 1.
DR FunFam; 3.30.40.10:FF:000610; TNF receptor-associated factor; 1.
DR FunFam; 3.30.40.10:FF:000649; TNF receptor-associated factor; 1.
DR Gene3D; 2.60.210.10; Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2, Chain A; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 4.
DR InterPro; IPR012227; TNF_rcpt-assoc_TRAF_met.
DR InterPro; IPR008974; TRAF-like.
DR InterPro; IPR049342; TRAF1-6_MATH_dom.
DR InterPro; IPR018957; Znf_C3HC4_RING-type.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR InterPro; IPR017907; Znf_RING_CS.
DR InterPro; IPR001293; Znf_TRAF.
DR PANTHER; PTHR10131; TNF RECEPTOR ASSOCIATED FACTOR; 1.
DR PANTHER; PTHR10131:SF94; TNF RECEPTOR-ASSOCIATED FACTOR 4; 1.
DR Pfam; PF21355; TRAF-mep_MATH; 1.
DR Pfam; PF00097; zf-C3HC4; 1.
DR Pfam; PF02176; zf-TRAF; 2.
DR PIRSF; PIRSF015614; TRAF; 1.
DR SMART; SM00184; RING; 1.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR SUPFAM; SSF49599; TRAF domain-like; 3.
DR PROSITE; PS00518; ZF_RING_1; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
DR PROSITE; PS50145; ZF_TRAF; 3.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490, ECO:0000256|PIRNR:PIRNR015614};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|PIRNR:PIRNR015614};
KW Reference proteome {ECO:0000313|Proteomes:UP000694394};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|PIRNR:PIRNR015614};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00207}.
FT DOMAIN 18..58
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS50089"
FT DOMAIN 102..154
FT /note="TRAF-type"
FT /evidence="ECO:0000259|PROSITE:PS50145"
FT DOMAIN 155..208
FT /note="TRAF-type"
FT /evidence="ECO:0000259|PROSITE:PS50145"
FT DOMAIN 209..266
FT /note="TRAF-type"
FT /evidence="ECO:0000259|PROSITE:PS50145"
FT ZN_FING 102..154
FT /note="TRAF-type"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00207"
FT ZN_FING 155..208
FT /note="TRAF-type"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00207"
FT ZN_FING 209..266
FT /note="TRAF-type"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00207"
FT COILED 278..305
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 427 AA; 48262 MW; F27F63BAF18D705F CRC64;
MPGFDYKFLE KPKRRLLCPL CGKPMREPVQ VSTCGHRFCD TCLQEFLSEG VFKCPEDQLP
LDYAKIYPDP ELEVQVLGLP IRCIHSEEGC RWSGQLRHLQ GHLNTCSFNV VPCPNRCPAK
LSRRDLPAHL QHDCPKRRLK CEFCGCDFSG EAYESHEGMC PQESVYCENK CGARMMRRLL
AQHATSECPK RTQPCTYCTK EFVFDTIQSH QYQCPRLPVP CPNQCGVGTV AREDLPGHLK
DSCSTALVLC PFKDSGCKHR CPKLAMARHV EESVKPHLAM MCALVSRQRQ ELQELRRELE
ELSVGSDGVL IWKIGSYGRR LQEAKAKPNL ECFSPAFYTH KYGYKLQVSA FLNGNGSGEG
THLSLYIRVL PGAFDNLLEW PFARRGLSPL LGRADMPWCR PHPARTEVPV QVLSPKSHRS
GELGIGE
//
