ID A0A8C5VVK7_MICMU Unreviewed; 513 AA.
AC A0A8C5VVK7;
DT 19-JAN-2022, integrated into UniProtKB/TrEMBL.
DT 19-JAN-2022, sequence version 1.
DT 28-JAN-2026, entry version 19.
DE SubName: Full=Suppressor of cytokine signaling 5 {ECO:0000313|Ensembl:ENSMICP00000031282.2};
GN Name=SOCS5 {ECO:0000313|Ensembl:ENSMICP00000031282.2};
OS Microcebus murinus (Gray mouse lemur) (Lemur murinus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lemuriformes;
OC Cheirogaleidae; Microcebus.
OX NCBI_TaxID=30608 {ECO:0000313|Ensembl:ENSMICP00000031282.2, ECO:0000313|Proteomes:UP000694394};
RN [1] {ECO:0000313|Ensembl:ENSMICP00000031282.2}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Harris R., Larsen P., Liu Y., Hughes D.S., Murali S., Raveendran M.,
RA Korchina V., Wang M., Jhangiani S., Bandaranaike D., Bellair M.,
RA Blankenburg K., Chao H., Dahdouli M., Dinh H., Doddapaneni H., English A.,
RA Firestine M., Gnanaolivu R., Gross S., Hernandez B., Javaid M.,
RA Jayaseelan J., Jones J., Khan Z., Kovar C., Kurapati P., Le B., Lee S.,
RA Li M., Mathew T., Narasimhan A., Ngo D., Nguyen L., Okwuonu G., Ongeri F.,
RA Osuji N., Pu L.-L., Puazo M., Quiroz J., Raj R., Rajbhandari K., Reid J.G.,
RA Santibanez J., Sexton D., Skinner E., Vee V., Weissenberger G., Wu Y.,
RA Xin Y., Han Y., Campbell C., Brown A., Sullivan B., Shelton J., Brown S.,
RA Dudchenko O., Machol I., Durand N., Shamim M., Lieberman A., Muzny D.M.,
RA Richards S., Yoder A., Worley K.C., Rogers J., Gibbs R.A.;
RT "Mouse lemur reference genome and diversity panel.";
RL Submitted (DEC-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSMICP00000031282.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (AUG-2025) to UniProtKB.
RN [3] {ECO:0000313|Ensembl:ENSMICP00000031282.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2025) to UniProtKB.
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC {ECO:0000256|ARBA:ARBA00004906}.
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DR EMBL; ABDC03011816; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A8C5VVK7; -.
DR Ensembl; ENSMICT00000004705.3; ENSMICP00000031282.2; ENSMICG00000004709.3.
DR GeneTree; ENSGT00940000159000; -.
DR UniPathway; UPA00143; -.
DR Proteomes; UP000694394; Chromosome 8.
DR GO; GO:0005942; C:phosphatidylinositol 3-kinase complex; IEA:TreeGrafter.
DR GO; GO:0046935; F:1-phosphatidylinositol-3-kinase regulator activity; IEA:TreeGrafter.
DR GO; GO:0005154; F:epidermal growth factor receptor binding; IEA:Ensembl.
DR GO; GO:0030971; F:receptor tyrosine kinase binding; IEA:Ensembl.
DR GO; GO:0007259; P:cell surface receptor signaling pathway via JAK-STAT; IEA:InterPro.
DR GO; GO:0071404; P:cellular response to low-density lipoprotein particle stimulus; IEA:Ensembl.
DR GO; GO:0019221; P:cytokine-mediated signaling pathway; IEA:Ensembl.
DR GO; GO:0007173; P:epidermal growth factor receptor signaling pathway; IEA:Ensembl.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR GO; GO:0050728; P:negative regulation of inflammatory response; IEA:Ensembl.
DR GO; GO:0032715; P:negative regulation of interleukin-6 production; IEA:Ensembl.
DR GO; GO:0071638; P:negative regulation of monocyte chemotactic protein-1 production; IEA:Ensembl.
DR GO; GO:0009968; P:negative regulation of signal transduction; IEA:UniProtKB-KW.
DR GO; GO:0045629; P:negative regulation of T-helper 2 cell differentiation; IEA:Ensembl.
DR GO; GO:0046854; P:phosphatidylinositol phosphate biosynthetic process; IEA:TreeGrafter.
DR GO; GO:0032436; P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process; IEA:Ensembl.
DR GO; GO:0045627; P:positive regulation of T-helper 1 cell differentiation; IEA:Ensembl.
DR GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR GO; GO:0097699; P:vascular endothelial cell response to fluid shear stress; IEA:Ensembl.
DR CDD; cd03739; SOCS_SOCS5; 1.
DR FunFam; 3.30.505.10:FF:000028; Suppressor of cytokine signaling 5; 1.
DR Gene3D; 3.30.505.10; SH2 domain; 1.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR022252; SOCS4/SOCS5_dom.
DR InterPro; IPR037343; SOCS5_SOCS.
DR InterPro; IPR001496; SOCS_box.
DR InterPro; IPR036036; SOCS_box-like_dom_sf.
DR PANTHER; PTHR10155; PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT; 1.
DR PANTHER; PTHR10155:SF15; SUPPRESSOR OF CYTOKINE SIGNALING 5; 1.
DR Pfam; PF00017; SH2; 1.
DR Pfam; PF12610; SOCS; 1.
DR Pfam; PF07525; SOCS_box; 1.
DR SMART; SM00252; SH2; 1.
DR SMART; SM00253; SOCS; 1.
DR SMART; SM00969; SOCS_box; 1.
DR SUPFAM; SSF55550; SH2 domain; 1.
DR SUPFAM; SSF158235; SOCS box-like; 1.
DR PROSITE; PS50001; SH2; 1.
DR PROSITE; PS50225; SOCS; 1.
PE 4: Predicted;
KW Growth regulation {ECO:0000256|ARBA:ARBA00022604};
KW Reference proteome {ECO:0000313|Proteomes:UP000694394};
KW SH2 domain {ECO:0000256|ARBA:ARBA00022999, ECO:0000256|PROSITE-
KW ProRule:PRU00191};
KW Signal transduction inhibitor {ECO:0000256|ARBA:ARBA00022700};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786}.
FT DOMAIN 358..453
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT DOMAIN 448..497
FT /note="SOCS box"
FT /evidence="ECO:0000259|PROSITE:PS50225"
FT REGION 115..166
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 513 AA; 58686 MW; 5177702810CE5F7D CRC64;
MDKVGKMWNN FKYRCQNLFS HEGGSRGESV DMNSNRCLSA KERSISVVDS APQQQSSPLR
ENVALQLGLN PSKNSSRRNQ NCATEIPQIV EISIEKDNDS CVTPGTRLAR RDSYSRHAPW
GGKKKHSCST KTQSSLDTDK KFGRTRSGLQ RRERRYGVSS VHDMDSVSSR TVGSRSLRQR
LQDTVGLCFP MRTYNKQSKP LFSNKRKIHL SELMLEKCPF PAAPHSTFFD TFDPSLVSTE
DEEDRLRERR RLSIEEGVDP PPNAQIHTFE ATAQVNPLYK LGPKLAPGMT EISGDSSAIP
QTSCDSEEDT TTLCLQSRRQ KQHSHAHVSR QGAWKVHTQI DYIHCLVPDL LQITGNPCYW
GVMDRYEAEA LLEGKPEGTF LLRDSAQEDY LFSVSFRRYN RSLHARIEQW NHNFSFDAHD
PCVFHSSTVT GLLEHYKDPS SCMFFEPLLT ISLNRTFPFS LQYICRAVIC RCTTYDGIDG
LPLPSMLQDF LKEYHYKQKV RVRWLEREPV KAK
//
