ID A0A8C5XDZ0_MICMU Unreviewed; 818 AA.
AC A0A8C5XDZ0;
DT 19-JAN-2022, integrated into UniProtKB/TrEMBL.
DT 19-JAN-2022, sequence version 1.
DT 28-JAN-2026, entry version 19.
DE SubName: Full=Zinc finger protein 598, E3 ubiquitin ligase {ECO:0000313|Ensembl:ENSMICP00000011702.3};
GN Name=ZNF598 {ECO:0000313|Ensembl:ENSMICP00000011702.3};
OS Microcebus murinus (Gray mouse lemur) (Lemur murinus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lemuriformes;
OC Cheirogaleidae; Microcebus.
OX NCBI_TaxID=30608 {ECO:0000313|Ensembl:ENSMICP00000011702.3, ECO:0000313|Proteomes:UP000694394};
RN [1] {ECO:0000313|Ensembl:ENSMICP00000011702.3}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Harris R., Larsen P., Liu Y., Hughes D.S., Murali S., Raveendran M.,
RA Korchina V., Wang M., Jhangiani S., Bandaranaike D., Bellair M.,
RA Blankenburg K., Chao H., Dahdouli M., Dinh H., Doddapaneni H., English A.,
RA Firestine M., Gnanaolivu R., Gross S., Hernandez B., Javaid M.,
RA Jayaseelan J., Jones J., Khan Z., Kovar C., Kurapati P., Le B., Lee S.,
RA Li M., Mathew T., Narasimhan A., Ngo D., Nguyen L., Okwuonu G., Ongeri F.,
RA Osuji N., Pu L.-L., Puazo M., Quiroz J., Raj R., Rajbhandari K., Reid J.G.,
RA Santibanez J., Sexton D., Skinner E., Vee V., Weissenberger G., Wu Y.,
RA Xin Y., Han Y., Campbell C., Brown A., Sullivan B., Shelton J., Brown S.,
RA Dudchenko O., Machol I., Durand N., Shamim M., Lieberman A., Muzny D.M.,
RA Richards S., Yoder A., Worley K.C., Rogers J., Gibbs R.A.;
RT "Mouse lemur reference genome and diversity panel.";
RL Submitted (DEC-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSMICP00000011702.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (AUG-2025) to UniProtKB.
RN [3] {ECO:0000313|Ensembl:ENSMICP00000011702.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2025) to UniProtKB.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; ABDC03020800; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A8C5XDZ0; -.
DR Ensembl; ENSMICT00000012845.3; ENSMICP00000011702.3; ENSMICG00000012834.3.
DR GeneTree; ENSGT00390000014178; -.
DR Proteomes; UP000694394; Chromosome 17.
DR GO; GO:0043022; F:ribosome binding; IEA:TreeGrafter.
DR GO; GO:0061630; F:ubiquitin protein ligase activity; IEA:InterPro.
DR GO; GO:0016567; P:protein ubiquitination; IEA:TreeGrafter.
DR GO; GO:0072344; P:rescue of stalled ribosome; IEA:InterPro.
DR InterPro; IPR057634; PAH_ZNF598/HEL2.
DR InterPro; IPR056437; Znf-C2H2_ZNF598/HEL2.
DR InterPro; IPR044288; ZNF598/HEL2.
DR InterPro; IPR013087; Znf_C2H2_type.
DR InterPro; IPR059042; Znf_C2H2_ZNF598.
DR PANTHER; PTHR22938:SF0; E3 UBIQUITIN-PROTEIN LIGASE ZNF598; 1.
DR PANTHER; PTHR22938; ZINC FINGER PROTEIN 598; 1.
DR Pfam; PF23202; PAH_ZNF598; 1.
DR Pfam; PF25447; RING_ZNF598; 1.
DR Pfam; PF23230; zf-C2H2_13; 1.
DR Pfam; PF23208; zf_C2H2_ZNF598; 1.
DR SMART; SM00355; ZnF_C2H2; 5.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000694394}.
FT DOMAIN 134..155
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS00028"
FT REGION 217..366
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 380..409
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 458..627
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 749..768
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 288..300
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 301..330
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 393..408
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 464..480
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 482..491
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 502..527
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 595..609
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 818 AA; 89295 MW; B6C2EF5CA52F6198 CRC64;
MRVLCEQRYC AVCREELRQV VFGKKLPAFA TIPIHQLQHE KKYDIYFADG KVFALYRQLL
QHECPRCPEL PPFSLFGDLE QHMRKQHELF CCRLCLQHLQ IFTYERKWYS RKDLARHRMQ
GDPDDTSHRG HPLCKFCDER YLDNDELLKH LRRDHYFCHF CDADGAQDYY SDYAYLREHF
REKHFLCEEG RCSTEQFTHA FRTEIDLKAH KTACHSRSRA EARQNRQIDL QFSYAPRHSR
RNEGVVGGED YEEVDRYSRA SRAGTRGAQQ SRRGSWRYKR EEEDREVAAA VRASVAAQQQ
EETRRSEDRE EGGRPKKEEA AARGPEEARG PRRMPRAQGE GPGAKETSTN GPVGQETFPG
MGPATGAAPL RYVGDWAGAL PSSTPKLKDE DFPSLSASTS SFSTAAAPGP VGLGLVYPVL
ARGRGRNTFQ EEDFPALVSS ACKPSTAPTS LISAWNSSCS KKVAQPTPAA QPAGGASQPT
RKAGKGSKGK KGGPPPVEEE GSGQQLRSAR STVSTVSASS PSGLASAQTS KVGRKKKVGS
EKPSATSPQP LPPTCAAKPL GAEQAPEAPT SRGEGPVAII NGHAEGPAPA RSAPKEPPGL
PRPLGPLPCP TSQEDFPALG GPCPPRMPPP PGFNTVVLLK GTPPPPPPGL APPVSKPPPG
FSGLLPSPHP ACVPSPWAMI KAGASTAGLP AERRGLACLS RGMISAAQYY KSCRDLLGEN
FQKIFNELLV LLPDTAKQQE LLSAHADFHT RDKPAGTKSK KNKKSAWQTD TRQTGLDCCV
CPTCQQVLAH GDVSSHQALH AARDDDFPSL QAIARIIT
//
