ID A0A8C6KQ99_NOTFU Unreviewed; 392 AA.
AC A0A8C6KQ99;
DT 19-JAN-2022, integrated into UniProtKB/TrEMBL.
DT 19-JAN-2022, sequence version 1.
DT 28-JAN-2026, entry version 20.
DE SubName: Full=Suppressor of cytokine signaling 4 {ECO:0000313|EMBL:KAF7212553.1, ECO:0000313|Ensembl:ENSNFUP00015009264.1};
GN Name=socs4 {ECO:0000313|Ensembl:ENSNFUP00015009264.1};
GN ORFNames=G4P62_007472 {ECO:0000313|EMBL:KAF7212553.1};
OS Nothobranchius furzeri (Turquoise killifish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Nothobranchiidae;
OC Nothobranchius.
OX NCBI_TaxID=105023 {ECO:0000313|Ensembl:ENSNFUP00015009264.1, ECO:0000313|Proteomes:UP000694548};
RN [1] {ECO:0000313|Ensembl:ENSNFUP00015009264.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=GRZ {ECO:0000313|Ensembl:ENSNFUP00015009264.1};
RA Senf B., Petzold A., Downie B.R., Koch P., Platzer M.;
RL Submitted (AUG-2014) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:KAF7212553.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=GRZ {ECO:0000313|EMBL:KAF7212553.1};
RC TISSUE=Whole {ECO:0000313|EMBL:KAF7212553.1};
RA Willemsen D., Cui R., Valenzano D.R.;
RT "Intra-Species Differences in Population Size shape Life History and Genome
RT Evolution.";
RL Submitted (MAR-2020) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSNFUP00015009264.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (MAY-2025) to UniProtKB.
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC {ECO:0000256|ARBA:ARBA00004906}.
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DR EMBL; JAAVVJ010000011; KAF7212553.1; -; Genomic_DNA.
DR RefSeq; XP_015809213.1; XM_015953727.3.
DR AlphaFoldDB; A0A8C6KQ99; -.
DR Ensembl; ENSNFUT00015009738.1; ENSNFUP00015009264.1; ENSNFUG00015004506.1.
DR GeneID; 107381831; -.
DR KEGG; nfu:107381831; -.
DR GeneTree; ENSGT00940000166202; -.
DR OMA; KCDGACA; -.
DR OrthoDB; 8820570at2759; -.
DR UniPathway; UPA00143; -.
DR Proteomes; UP000694548; Chromosome sgr07.
DR Proteomes; UP000822369; Chromosome 11.
DR GO; GO:0005942; C:phosphatidylinositol 3-kinase complex; IEA:TreeGrafter.
DR GO; GO:0046935; F:1-phosphatidylinositol-3-kinase regulator activity; IEA:TreeGrafter.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR GO; GO:0009968; P:negative regulation of signal transduction; IEA:UniProtKB-KW.
DR GO; GO:0046854; P:phosphatidylinositol phosphate biosynthetic process; IEA:TreeGrafter.
DR GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR Gene3D; 3.30.505.10; SH2 domain; 1.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR022252; SOCS4/SOCS5_dom.
DR InterPro; IPR001496; SOCS_box.
DR InterPro; IPR036036; SOCS_box-like_dom_sf.
DR PANTHER; PTHR10155; PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT; 1.
DR PANTHER; PTHR10155:SF35; SUPPRESSOR OF CYTOKINE SIGNALING 4 ISOFORM X1; 1.
DR Pfam; PF00017; SH2; 1.
DR Pfam; PF12610; SOCS; 1.
DR Pfam; PF07525; SOCS_box; 1.
DR SMART; SM00252; SH2; 1.
DR SMART; SM00253; SOCS; 1.
DR SMART; SM00969; SOCS_box; 1.
DR SUPFAM; SSF55550; SH2 domain; 1.
DR SUPFAM; SSF158235; SOCS box-like; 1.
DR PROSITE; PS50001; SH2; 1.
DR PROSITE; PS50225; SOCS; 1.
PE 4: Predicted;
KW Growth regulation {ECO:0000256|ARBA:ARBA00022604};
KW Reference proteome {ECO:0000313|Proteomes:UP000694548};
KW SH2 domain {ECO:0000256|ARBA:ARBA00022999, ECO:0000256|PROSITE-
KW ProRule:PRU00191};
KW Signal transduction inhibitor {ECO:0000256|ARBA:ARBA00022700};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786}.
FT DOMAIN 246..341
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT DOMAIN 336..385
FT /note="SOCS box"
FT /evidence="ECO:0000259|PROSITE:PS50225"
FT REGION 28..57
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 28..37
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 392 AA; 44408 MW; 8C4FCB66859F0F9C CRC64;
MSEKKPRGAD ARPKSGLRSW SADSYIWRGK KRSRRSRNGS SPGGLEADGT EELGVHSTSC
SRRRRERKCS CSALGETLTA TDFDGVCRKA LSRRSLRQKF QDAVGQCFPL RSHHHHHYHH
PPGSSRPFSV LFWSKRKIHV SELMQDKCPF SPKSELSKCW HLIKSQVPHP SALKDMKAPL
KVSVSSSTSP PQTPISWEDI CSSPGPGTAP LDEWDPSCRR GGADGSCDNT DYILVPDLLQ
INNNPCYWGV LNRFEAEELL DGQPEGTFLL RDSAQDEFLF SVSFRRYSRS LHARIEQNSK
RFSFDVRDPC MYRDPSITGL LRHYSDPATC LFFEPLLSRP LPRTFPFHLQ HLCRAVICSC
TTYQGIDGLP LPPQLREYLR QYHIRCDGAC AV
//
