ID   A0A8C6MHL9_NOTFU        Unreviewed;       388 AA.
AC   A0A8C6MHL9;
DT   19-JAN-2022, integrated into UniProtKB/TrEMBL.
DT   19-JAN-2022, sequence version 1.
DT   28-JAN-2026, entry version 18.
DE   SubName: Full=ADRM1 26S proteasome ubiquitin receptor {ECO:0000313|Ensembl:ENSNFUP00015032330.1};
GN   Name=ADRM1 {ECO:0000313|Ensembl:ENSNFUP00015032330.1};
GN   Synonyms=LOC107390550 {ECO:0000313|Ensembl:ENSNFUP00015032330.1};
OS   Nothobranchius furzeri (Turquoise killifish).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Cyprinodontiformes; Nothobranchiidae;
OC   Nothobranchius.
OX   NCBI_TaxID=105023 {ECO:0000313|Ensembl:ENSNFUP00015032330.1, ECO:0000313|Proteomes:UP000694548};
RN   [1] {ECO:0000313|Ensembl:ENSNFUP00015032330.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=GRZ {ECO:0000313|Ensembl:ENSNFUP00015032330.1};
RA   Senf B., Petzold A., Downie B.R., Koch P., Platzer M.;
RL   Submitted (AUG-2014) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSNFUP00015032330.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (AUG-2025) to UniProtKB.
RN   [3] {ECO:0000313|Ensembl:ENSNFUP00015032330.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2025) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC       Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC   -!- SIMILARITY: Belongs to the ADRM1 family.
CC       {ECO:0000256|ARBA:ARBA00009216}.
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DR   AlphaFoldDB; A0A8C6MHL9; -.
DR   Ensembl; ENSNFUT00015033788.1; ENSNFUP00015032330.1; ENSNFUG00015015836.1.
DR   GeneTree; ENSGT00390000013839; -.
DR   Proteomes; UP000694548; Chromosome sgr15.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0008541; C:proteasome regulatory particle, lid subcomplex; IEA:TreeGrafter.
DR   GO; GO:0061133; F:endopeptidase activator activity; IEA:TreeGrafter.
DR   GO; GO:0070628; F:proteasome binding; IEA:TreeGrafter.
DR   CDD; cd13314; PH_Rpn13; 1.
DR   FunFam; 1.10.2020.20:FF:000001; Proteasomal ubiquitin receptor ADRM1; 1.
DR   FunFam; 2.30.29.70:FF:000001; Proteasomal ubiquitin receptor ADRM1; 1.
DR   Gene3D; 1.10.2020.20; -; 1.
DR   Gene3D; 2.30.29.70; Proteasomal ubiquitin receptor Rpn13/ADRM1; 1.
DR   InterPro; IPR044867; DEUBAD_dom.
DR   InterPro; IPR006773; Rpn13/ADRM1.
DR   InterPro; IPR044868; Rpn13/ADRM1_Pru.
DR   InterPro; IPR038633; Rpn13/ADRM1_Pru_sf.
DR   InterPro; IPR032368; RPN13_DEUBAD.
DR   InterPro; IPR038108; RPN13_DEUBAD_sf.
DR   PANTHER; PTHR12225; ADHESION REGULATING MOLECULE 1 110 KDA CELL MEMBRANE GLYCOPROTEIN; 1.
DR   PANTHER; PTHR12225:SF0; PROTEASOMAL UBIQUITIN RECEPTOR ADRM1; 1.
DR   Pfam; PF04683; Rpn13_ADRM1_Pru; 1.
DR   Pfam; PF16550; RPN13_C; 1.
DR   PROSITE; PS51916; DEUBAD; 1.
DR   PROSITE; PS51917; PRU; 1.
PE   3: Inferred from homology;
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW   Proteasome {ECO:0000256|ARBA:ARBA00022942};
KW   Reference proteome {ECO:0000313|Proteomes:UP000694548}.
FT   DOMAIN          17..130
FT                   /note="Pru"
FT                   /evidence="ECO:0000259|PROSITE:PS51917"
FT   DOMAIN          291..388
FT                   /note="DEUBAD"
FT                   /evidence="ECO:0000259|PROSITE:PS51916"
FT   REGION          195..274
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        195..231
FT                   /note="Low complexity"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        241..265
FT                   /note="Low complexity"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   388 AA;  40148 MW;  3931808F00C3C261 CRC64;
     MSSGALFPSL VSNSRGSSSK YLVEFRAGKM TLKGNTVTPD KRKGTVYIQQ SDDSLIHFCW
     KDRTTGNVDD DLIIFPDDCE FKRVNQCTTG RVYVLKFKAG SKRLFFWMQE PKMEKDEEFC
     RKVNEFLNNP PVPGAAGSGG GSGHELSALG GEGGLQNLLG NMSHNQLMQL IGPTGLGGLG
     GLGALAGPGL ANLLGSGGPP TSSSSSSSRS QAASVATPPS GGGPRLSSPQ VPTTPAPPPV
     AASSPTSVTP STPAPAPTQV TPASVGSPPP HQPIQLSDLQ SILANMNVPA AAAQGALVDL
     ATVCTPEMMA PILSNPDIQQ RLLPFLPSGE SLPQSAEEIQ NTLTSPQFQQ SMSLFSSALA
     SGQLGPLMSQ FGLSAEAVDA ANRGGRTH
//