ID A0A8C6RBM8_NANGA Unreviewed; 599 AA.
AC A0A8C6RBM8;
DT 19-JAN-2022, integrated into UniProtKB/TrEMBL.
DT 19-JAN-2022, sequence version 1.
DT 28-JAN-2026, entry version 19.
DE RecName: Full=ATP-binding cassette sub-family E member 1 {ECO:0000256|ARBA:ARBA00069435};
DE AltName: Full=RNase L inhibitor {ECO:0000256|ARBA:ARBA00081891};
DE AltName: Full=Ribonuclease 4 inhibitor {ECO:0000256|ARBA:ARBA00078674};
GN Name=Abce1 {ECO:0000313|Ensembl:ENSNGAP00000015881.1};
OS Nannospalax galili (Northern Israeli blind subterranean mole rat) (Spalax
OS galili).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea;
OC Spalacidae; Spalacinae; Nannospalax.
OX NCBI_TaxID=1026970 {ECO:0000313|Ensembl:ENSNGAP00000015881.1, ECO:0000313|Proteomes:UP000694381};
RN [1] {ECO:0000313|Ensembl:ENSNGAP00000015881.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (AUG-2025) to UniProtKB.
RN [2] {ECO:0000313|Ensembl:ENSNGAP00000015881.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2025) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=CTP + H2O = CDP + phosphate + H(+); Xref=Rhea:RHEA:29387,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:37563,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:58069;
CC Evidence={ECO:0000256|ARBA:ARBA00051233};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=GTP + H2O = GDP + phosphate + H(+); Xref=Rhea:RHEA:19669,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:37565,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:58189;
CC Evidence={ECO:0000256|ARBA:ARBA00048548};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=UTP + H2O = UDP + phosphate + H(+); Xref=Rhea:RHEA:64900,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:43474,
CC ChEBI:CHEBI:46398, ChEBI:CHEBI:58223;
CC Evidence={ECO:0000256|ARBA:ARBA00052409};
CC -!- SUBUNIT: Interacts with PINK1. Interacts with CNOT4. Interacts with
CC PELO. Probably heterodimerizes with RNASEL; this interaction inhibits
CC RNASEL. {ECO:0000256|ARBA:ARBA00065921}.
CC -!- SIMILARITY: Belongs to the ABC transporter superfamily. ABCE family.
CC {ECO:0000256|ARBA:ARBA00061689}.
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DR RefSeq; XP_008825705.1; XM_008827483.3.
DR AlphaFoldDB; A0A8C6RBM8; -.
DR SMR; A0A8C6RBM8; -.
DR Ensembl; ENSNGAT00000021490.1; ENSNGAP00000015881.1; ENSNGAG00000016777.1.
DR GeneID; 103729408; -.
DR KEGG; ngi:103729408; -.
DR CTD; 6059; -.
DR GeneTree; ENSGT00390000015089; -.
DR OMA; MVCIQNG; -.
DR OrthoDB; 6593433at2759; -.
DR Proteomes; UP000694381; Unassembled WGS sequence.
DR GO; GO:0022626; C:cytosolic ribosome; IEA:Ensembl.
DR GO; GO:0005739; C:mitochondrion; IEA:Ensembl.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:Ensembl.
DR GO; GO:0043273; F:CTPase activity; IEA:Ensembl.
DR GO; GO:0060698; F:endoribonuclease inhibitor activity; IEA:Ensembl.
DR GO; GO:0003924; F:GTPase activity; IEA:Ensembl.
DR GO; GO:0140708; P:CAT tailing; IEA:Ensembl.
DR GO; GO:0071569; P:protein ufmylation; IEA:Ensembl.
DR GO; GO:0060255; P:regulation of macromolecule metabolic process; IEA:UniProtKB-ARBA.
DR GO; GO:0006415; P:translational termination; IEA:Ensembl.
DR CDD; cd03236; ABC_RNaseL_inhibitor_domain1; 1.
DR CDD; cd03237; ABC_RNaseL_inhibitor_domain2; 1.
DR FunFam; 3.40.50.300:FF:000144; ATP-binding cassette sub-family E member 1; 1.
DR FunFam; 3.40.50.300:FF:000152; ATP-binding cassette, sub-family E, member 1; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR017896; 4Fe4S_Fe-S-bd.
DR InterPro; IPR017900; 4Fe4S_Fe_S_CS.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR017871; ABC_transporter-like_CS.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR013283; RLI1.
DR InterPro; IPR034348; RLI_dom_1.
DR InterPro; IPR007209; RNaseL-inhib-like_metal-bd_dom.
DR NCBIfam; NF009945; PRK13409.1; 1.
DR PANTHER; PTHR19248; ATP-BINDING TRANSPORT PROTEIN-RELATED; 1.
DR Pfam; PF00005; ABC_tran; 2.
DR Pfam; PF00037; Fer4; 1.
DR Pfam; PF04068; Fer4_RLI; 1.
DR PRINTS; PR01868; ABCEFAMILY.
DR SMART; SM00382; AAA; 2.
DR SUPFAM; SSF54862; 4Fe-4S ferredoxins; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS00198; 4FE4S_FER_1; 1.
DR PROSITE; PS51379; 4FE4S_FER_2; 1.
DR PROSITE; PS00211; ABC_TRANSPORTER_1; 1.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 2.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000694381}.
FT DOMAIN 46..75
FT /note="4Fe-4S ferredoxin-type"
FT /evidence="ECO:0000259|PROSITE:PS51379"
FT DOMAIN 79..315
FT /note="ABC transporter"
FT /evidence="ECO:0000259|PROSITE:PS50893"
FT DOMAIN 342..562
FT /note="ABC transporter"
FT /evidence="ECO:0000259|PROSITE:PS50893"
SQ SEQUENCE 599 AA; 67314 MW; 5D582B62E95BC7A6 CRC64;
MADKLTRIAI VNHDKCKPKK CRQECKKSCP VVRMGKLCIE VTPQSKIAWI SETLCIGCGI
CIKKCPFGAL SIVNLPSNLE KETTHRYCAN AFKLHRLPIP RPGEVLGLVG TNGIGKSTAL
KILAGKQKPN LGKYDDPPDW QEILTYFRGS ELQNYFTKIL EDDLKAIIKP QYVDQIPKAA
KGTVGSILDR KDETKTQAIV CQQLDLTHLK ERNVEDLSGG ELQRFACAVV CIQKADIFMF
DEPSSYLDVK QRLKAAITIR SLINPDRYII VVEHDLSVLD YLSDFICCLY GVPSAYGVVT
MPFSVREGIN IFLDGYVPTE NLRFRDASLV FKVAETANEE EVKKMCMYKY PGMKKKMGEF
ELAIVAGEFT DSEIMVMLGE NGTGKTTFIR MLAGRLKPDE GGEVPVLNVS YKPQKISPKS
TGSVRQLLHE KIRDAYTHPQ FVTDVMKPLQ IENIIDQEVQ TLSGGELQRV ALALCLGKPA
DVYLIDEPSA YLDSEQRLMA ARVVKRFILH AKKTAFVVEH DFIMATYLAD RVIVFDGVPS
KNTVANSPQT LLAGMNKFLS QLEITFRRDP NNYRPRINKL NSIKDVEQKK SGNYFFLDD
//
