ID A0A8C6UVG2_9GOBI Unreviewed; 419 AA.
AC A0A8C6UVG2;
DT 19-JAN-2022, integrated into UniProtKB/TrEMBL.
DT 19-JAN-2022, sequence version 1.
DT 28-JAN-2026, entry version 20.
DE SubName: Full=Suppressor of cytokine signaling 5b {ECO:0000313|Ensembl:ENSNMLP00000039870.1};
OS Neogobius melanostomus (round goby).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Gobiaria; Gobiiformes; Gobioidei; Gobiidae; Benthophilinae; Neogobiini;
OC Neogobius.
OX NCBI_TaxID=47308 {ECO:0000313|Ensembl:ENSNMLP00000039870.1, ECO:0000313|Proteomes:UP000694523};
RN [1] {ECO:0000313|Ensembl:ENSNMLP00000039870.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (AUG-2025) to UniProtKB.
RN [2] {ECO:0000313|Ensembl:ENSNMLP00000039870.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2025) to UniProtKB.
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC {ECO:0000256|ARBA:ARBA00004906}.
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DR AlphaFoldDB; A0A8C6UVG2; -.
DR Ensembl; ENSNMLT00000044366.1; ENSNMLP00000039870.1; ENSNMLG00000024545.1.
DR Proteomes; UP000694523; Unplaced.
DR GO; GO:0005942; C:phosphatidylinositol 3-kinase complex; IEA:TreeGrafter.
DR GO; GO:0046935; F:1-phosphatidylinositol-3-kinase regulator activity; IEA:TreeGrafter.
DR GO; GO:0009968; P:negative regulation of signal transduction; IEA:UniProtKB-KW.
DR GO; GO:0046854; P:phosphatidylinositol phosphate biosynthetic process; IEA:TreeGrafter.
DR FunFam; 3.30.505.10:FF:000028; Suppressor of cytokine signaling 5; 1.
DR Gene3D; 3.30.505.10; SH2 domain; 1.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR022252; SOCS4/SOCS5_dom.
DR PANTHER; PTHR10155; PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT; 1.
DR PANTHER; PTHR10155:SF15; SUPPRESSOR OF CYTOKINE SIGNALING 5; 1.
DR Pfam; PF00017; SH2; 1.
DR Pfam; PF12610; SOCS; 1.
DR SMART; SM00252; SH2; 1.
DR SUPFAM; SSF55550; SH2 domain; 1.
DR PROSITE; PS50001; SH2; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000694523};
KW SH2 domain {ECO:0000256|ARBA:ARBA00022999, ECO:0000256|PROSITE-
KW ProRule:PRU00191};
KW Signal transduction inhibitor {ECO:0000256|ARBA:ARBA00022700};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786}.
FT DOMAIN 276..371
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT REGION 36..74
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 194..224
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 232..251
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 63..72
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 419 AA; 47585 MW; 37D4957A89DBAEC2 CRC64;
MFLLITTSKC CYSVQSGSRN DVRGGAGVPL ARRDSYSRHA PWGGKKKHSC STKTQSSLEG
RSGRMRASRR ERRYGVSSAP EICDSVPGRG VNCRTLRQRF SDTVGLCLPL PTHRRSRSAK
SPISTKRKIH LTELMLETCP FPPGSDLAHK WHLIKQHTRL RERRRLSIEE GVDPPPNAQI
HTLEASVPSS TLYKLGPKMT PGLAEAEGHS GGASAQDCDS EEDSTTLCLQ ARRPKQRHSS
GEGHSRQQPG PWKVHTQIDY IHCLVPDLLQ ISSLPCYWGV MDRYEAESLL DGRPEGTFLL
RDSAQEDYLF SVSFRRYNRS LHARIEQWNH NFSFDAHDPC VFHSSTVTGL LEHYKDPSAC
MFFEPLLTAP LHRTFPFSLQ HLARAAICRW TTYDGIGEYH YKQKVRVRWL EREPPLKLK
//
