ID   A0A8C6XCI0_NAJNA        Unreviewed;       540 AA.
AC   A0A8C6XCI0;
DT   19-JAN-2022, integrated into UniProtKB/TrEMBL.
DT   19-JAN-2022, sequence version 1.
DT   28-JAN-2026, entry version 18.
DE   RecName: Full=YTH domain-containing family protein {ECO:0000256|RuleBase:RU369095};
GN   Name=YTHDF3 {ECO:0000313|Ensembl:ENSNNAP00000012228.1};
OS   Naja naja (Indian cobra).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC   Serpentes; Colubroidea; Elapidae; Elapinae; Naja.
OX   NCBI_TaxID=35670 {ECO:0000313|Ensembl:ENSNNAP00000012228.1, ECO:0000313|Proteomes:UP000694559};
RN   [1] {ECO:0000313|Ensembl:ENSNNAP00000012228.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (AUG-2025) to UniProtKB.
RN   [2] {ECO:0000313|Ensembl:ENSNNAP00000012228.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2025) to UniProtKB.
CC   -!- FUNCTION: Specifically recognizes and binds N6-methyladenosine (m6A)-
CC       containing RNAs, and regulates mRNA stability. M6A is a modification
CC       present at internal sites of mRNAs and some non-coding RNAs and plays a
CC       role in mRNA stability and processing. {ECO:0000256|RuleBase:RU369095}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, P-body
CC       {ECO:0000256|ARBA:ARBA00004201}. Cytoplasm, Stress granule
CC       {ECO:0000256|ARBA:ARBA00004210}.
CC   -!- SIMILARITY: Belongs to the YTHDF family.
CC       {ECO:0000256|RuleBase:RU369095}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   AlphaFoldDB; A0A8C6XCI0; -.
DR   SMR; A0A8C6XCI0; -.
DR   Ensembl; ENSNNAT00000012796.1; ENSNNAP00000012228.1; ENSNNAG00000008225.1.
DR   GeneTree; ENSGT00940000158777; -.
DR   OMA; GAYRSMG; -.
DR   OrthoDB; 306690at2759; -.
DR   Proteomes; UP000694559; Unplaced.
DR   GO; GO:0010494; C:cytoplasmic stress granule; IEA:UniProtKB-SubCell.
DR   GO; GO:0000932; C:P-body; IEA:UniProtKB-SubCell.
DR   GO; GO:0003729; F:mRNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:1990247; F:N6-methyladenosine-containing RNA reader activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0043022; F:ribosome binding; IEA:Ensembl.
DR   GO; GO:0061157; P:mRNA destabilization; IEA:Ensembl.
DR   GO; GO:0060339; P:negative regulation of type I interferon-mediated signaling pathway; IEA:Ensembl.
DR   GO; GO:0045948; P:positive regulation of translational initiation; IEA:Ensembl.
DR   GO; GO:0034063; P:stress granule assembly; IEA:Ensembl.
DR   CDD; cd21134; YTH; 1.
DR   FunFam; 3.10.590.10:FF:000001; YTH domain family 1, isoform CRA_a; 1.
DR   Gene3D; 3.10.590.10; ph1033 like domains; 1.
DR   InterPro; IPR007275; YTH_domain.
DR   InterPro; IPR045168; YTH_prot.
DR   PANTHER; PTHR12357:SF9; YTH DOMAIN-CONTAINING FAMILY PROTEIN 3; 1.
DR   PANTHER; PTHR12357; YTH YT521-B HOMOLOGY DOMAIN-CONTAINING; 1.
DR   Pfam; PF04146; YTH; 1.
DR   SUPFAM; SSF81995; beta-sandwich domain of Sec23/24; 1.
DR   PROSITE; PS50882; YTH; 1.
PE   3: Inferred from homology;
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   Reference proteome {ECO:0000313|Proteomes:UP000694559};
KW   RNA-binding {ECO:0000256|ARBA:ARBA00022884, ECO:0000256|RuleBase:RU369095}.
FT   DOMAIN          371..505
FT                   /note="YTH"
FT                   /evidence="ECO:0000259|PROSITE:PS50882"
FT   REGION          198..307
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        199..209
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        252..261
FT                   /note="Low complexity"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        269..280
FT                   /note="Low complexity"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        287..307
FT                   /note="Low complexity"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   540 AA;  59039 MW;  8CDD46E482FB8D05 CRC64;
     SNSYPPMSDP YMPSYYAPSI GFPYSLGEAA WSTAGDPPMP YLTTYGQMSN GEHHYIPDGV
     FSQPGALGNT PPFLGQHGFN FFPGNADFST WGTSGSQGQS TQSSAYSSSY GYPPSSLGRA
     IADGQAGFGN DTLSKVPGIS SIEQGMTGLK IGGEMTVAVT KTVGSALTST GMTSIAANNV
     PAVSSSAPKP TSWAAIARKP AKPQPKLKPK GNVGIGGPAV PPPPIKHNMN IGTWDDKGSV
     VKAPPTQPVL PPQTIIQQPQ PLIQPPPMVQ SQLPQQQQQQ QPPPQSQQPQ GPQQQAQPHQ
     LQQQQQLQNR WVANRGVGFN QSNGAGNENY GIGVIPVSSS PSGVEVHPVL EKLKAINNYN
     PKDFDWNLKN GRVFIIKSYS EDDIHRSIKY SIWCSTEHGN KRLDAAYRSL NGKGPLYLLF
     SVNGSGHFCG VAEMKSVVDY NAYAGVWSQD KWKGKFDVKW IFVKDVPNNQ LRHIRLENND
     NKPVTNSRDT QEVPLEKAKQ VLKIIATFKH TTSIFDDFAH YEKRQEEEEA MRRERNRNKQ
//