ID A0A8C6XWT7_NAJNA Unreviewed; 293 AA.
AC A0A8C6XWT7;
DT 19-JAN-2022, integrated into UniProtKB/TrEMBL.
DT 19-JAN-2022, sequence version 1.
DT 28-JAN-2026, entry version 18.
DE SubName: Full=Tonsoku like, DNA repair protein {ECO:0000313|Ensembl:ENSNNAP00000019530.1};
GN Name=TONSL {ECO:0000313|Ensembl:ENSNNAP00000019530.1};
OS Naja naja (Indian cobra).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC Serpentes; Colubroidea; Elapidae; Elapinae; Naja.
OX NCBI_TaxID=35670 {ECO:0000313|Ensembl:ENSNNAP00000019530.1, ECO:0000313|Proteomes:UP000694559};
RN [1] {ECO:0000313|Ensembl:ENSNNAP00000019530.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (AUG-2025) to UniProtKB.
RN [2] {ECO:0000313|Ensembl:ENSNNAP00000019530.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2025) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR AlphaFoldDB; A0A8C6XWT7; -.
DR Ensembl; ENSNNAT00000020499.1; ENSNNAP00000019530.1; ENSNNAG00000012967.1.
DR GeneTree; ENSGT00940000160188; -.
DR OrthoDB; 5806726at2759; -.
DR Proteomes; UP000694559; Unplaced.
DR GO; GO:0043596; C:nuclear replication fork; IEA:TreeGrafter.
DR GO; GO:0000724; P:double-strand break repair via homologous recombination; IEA:TreeGrafter.
DR GO; GO:0031297; P:replication fork processing; IEA:TreeGrafter.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR052311; MMS22L-TONSL_complex_comp.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR019734; TPR_rpt.
DR PANTHER; PTHR46358; TONSOKU-LIKE PROTEIN; 1.
DR PANTHER; PTHR46358:SF1; TONSOKU-LIKE PROTEIN; 1.
DR Pfam; PF12796; Ank_2; 1.
DR Pfam; PF13176; TPR_7; 1.
DR SMART; SM00248; ANK; 2.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR SUPFAM; SSF48452; TPR-like; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 1.
DR PROSITE; PS50088; ANK_REPEAT; 2.
PE 4: Predicted;
KW ANK repeat {ECO:0000256|PROSITE-ProRule:PRU00023};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000694559};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT REPEAT 197..229
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 230..262
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
SQ SEQUENCE 293 AA; 32551 MW; 7D32C219CBA01AC9 CRC64;
MGLESGPCPS PLWCDSSCLA ATKVSRLQEA LEEAEAASDL GAALGLSEQL GDLFCKVGEY
RRAAEAYEKQ LGHAQALGRT EQELAVIHVS LAATYGDLKD YVRAVQHYQA ELALRRGNPL
EEGKTWLNIA LAKEEAGKSY PELEPCFQAA LQAAQKAGDH KLEVSRVGCC LQKAVYDNTR
RWWVGAVFPQ WNQRNDKGET LLHRACIEGN LRQVQYFLEK EHPVNPRDYC GWTPLHEACN
HGHLETVRLL LDHGASIDDP GGPDCEGITP ELLIQRGASM LLRNAKPGIW RRW
//
