ID A0A8C7AHE0_NEOVI Unreviewed; 1285 AA.
AC A0A8C7AHE0;
DT 19-JAN-2022, integrated into UniProtKB/TrEMBL.
DT 19-JAN-2022, sequence version 1.
DT 10-JUN-2026, entry version 20.
DE RecName: Full=Zinc finger transcription factor Trps1 {ECO:0000256|ARBA:ARBA00073694};
OS Neogale vison (American mink) (Mustela vison).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Musteloidea; Mustelidae;
OC Mustelinae; Neogale.
OX NCBI_TaxID=452646 {ECO:0000313|Ensembl:ENSNVIP00000008768.1, ECO:0000313|Proteomes:UP000694425};
RN [1] {ECO:0000313|Ensembl:ENSNVIP00000008768.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (JAN-2026) to UniProtKB.
CC -!- FUNCTION: Transcriptional repressor. Binds specifically to GATA
CC sequences and represses expression of GATA-regulated genes at selected
CC sites and stages in vertebrate development. Regulates chondrocyte
CC proliferation and differentiation. Executes multiple functions in
CC proliferating chondrocytes, expanding the region of distal
CC chondrocytes, activating proliferation in columnar cells and supporting
CC the differentiation of columnar into hypertrophic chondrocytes.
CC {ECO:0000256|ARBA:ARBA00058641}.
CC -!- SUBUNIT: Interacts with RNF4; regulates TRPS1 repressor activity.
CC Interacts specifically with the activator form of GLI3 (GLI3A) but not
CC with the repressor form (GLI3R). {ECO:0000256|ARBA:ARBA00066009}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR Ensembl; ENSNVIT00000010260.1; ENSNVIP00000008768.1; ENSNVIG00000006947.1.
DR GeneTree; ENSGT00940000157893; -.
DR Proteomes; UP000694425; Unplaced.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IEA:TreeGrafter.
DR GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006351; P:DNA-templated transcription; IEA:UniProtKB-KW.
DR GO; GO:0045892; P:negative regulation of DNA-templated transcription; IEA:UniProtKB-ARBA.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:TreeGrafter.
DR GO; GO:0001501; P:skeletal system development; IEA:UniProtKB-ARBA.
DR CDD; cd00202; ZnF_GATA; 1.
DR FunFam; 3.30.160.60:FF:001213; Transcriptional repressor GATA binding 1; 1.
DR FunFam; 3.30.50.10:FF:000020; Zinc finger transcription factor Trps1; 1.
DR FunFam; 3.30.160.60:FF:000674; zinc finger transcription factor Trps1 isoform X2; 1.
DR Gene3D; 3.30.160.60; Classic Zinc Finger; 2.
DR Gene3D; 3.30.50.10; Erythroid Transcription Factor GATA-1, subunit A; 1.
DR InterPro; IPR028440; TRPS1.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR InterPro; IPR000679; Znf_GATA.
DR InterPro; IPR013088; Znf_NHR/GATA.
DR PANTHER; PTHR47034; ZINC FINGER TRANSCRIPTION FACTOR TRPS1; 1.
DR PANTHER; PTHR47034:SF1; ZINC FINGER TRANSCRIPTION FACTOR TRPS1; 1.
DR Pfam; PF00320; GATA; 1.
DR Pfam; PF27058; Znf_C2H2_Trps1_1st; 1.
DR Pfam; PF27065; Znf_C2H2_Trps1_2nd; 1.
DR Pfam; PF27047; Znf_C2H2_Trps1_3rd; 1.
DR Pfam; PF27082; Znf_C2H2_Trps1_4th; 1.
DR Pfam; PF27088; Znf_C2H2_Trps1_5th; 1.
DR PRINTS; PR00619; GATAZNFINGER.
DR SMART; SM00355; ZnF_C2H2; 9.
DR SMART; SM00401; ZnF_GATA; 1.
DR SUPFAM; SSF57667; beta-beta-alpha zinc fingers; 1.
DR SUPFAM; SSF57716; Glucocorticoid receptor-like (DNA-binding domain); 1.
DR PROSITE; PS00344; GATA_ZN_FINGER_1; 1.
DR PROSITE; PS50114; GATA_ZN_FINGER_2; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 2.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 1.
PE 4: Predicted;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Isopeptide bond {ECO:0000256|ARBA:ARBA00022499};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000694425};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Repressor {ECO:0000256|ARBA:ARBA00022491};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW Ubl conjugation {ECO:0000256|ARBA:ARBA00022843};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00042}.
FT DOMAIN 696..724
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 894..952
FT /note="GATA-type"
FT /evidence="ECO:0000259|PROSITE:PS50114"
FT REGION 1..202
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 367..398
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 489..516
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 860..891
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 965..1004
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1043..1085
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1173..1198
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..11
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 44..53
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 68..87
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 152..166
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 167..193
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 492..516
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 965..981
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 984..999
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1044..1053
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1054..1063
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1064..1076
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1285 AA; 141345 MW; 14C84225F11508E2 CRC64;
MQSNMVRKKN PPLRNVASEG EGQSLEPIGT ESKVSGKNKE FSADQMSENT DQSDAAELNN
KEEHSSHGQD PSSSSKKGLK SSVLSEKAGF NYESPSKGGN LPSHPHDEVT DRNMLAFSSP
AAGGVCEPLK SPQRAEADDP QDMACTPSGD SLETKEDHKM SPKATEETGQ AQSGQANCQG
SSPVSVASKN PQVPSDGGVR LNKSKTDLLV NDIPDPAPLS PELQDFKCNI CGYGYYGNDP
TDLIKHFRKY HLGLHNRTRQ DAELDSKILA LHNMVQFSHS KDFQKVNRSV LSGVLQDINS
SRPVLLNGTY DVQVTSGGTF IGIGRKTPDC QGNTKYFRCK FCNFTYMGNS STELEQHFLQ
THPNKIKASL PSSEGAKPSE KNSNKSIPAL RSSDSGDLGK WQDKITVKTG DDTPVGYSVP
IKPLDSSRQN GTEATSYYWC KFCSFSCESS SSLKLLEHYG KQHGGAQSGG LNPELNDKLS
RGSVINQNDL AKSAEGEPMA KADKGSSGAK KKDFSSKGAE DNMVTSYNCQ FCDFRYSKSH
GPDVIVVGPL LRHYQQLHNI HKCTIKHCPF CPRGLCSPEK HLGEITYPFA CRKSNCSHCA
LLLLHLSPGA AGSSRVKHQC HQCSFSTPDV DVLLFHYESS HESQASEVKQ EANHLQGSDG
QPAVKESKEH SCTKCDFITQ VEEEISRHYR RAHSCYKCRQ CSFTAADTQS LLEHFNTVHC
HEQDITTANG EEDGHAVSTI KEEPKIDLKV YSLLNPDSKM GEPVSESVVK REKVEDKDGL
KDKVWTESSS DDLRNMTWRG ADILRGSPSY TQASLGLLTP VSGPQEQTKT LRDSPNVEAA
HLARPIYGLA VETKGFLQGV PAGGEKSGTL TQQYPASGEN KSKDESQSLL RRRRGSGVFC
ANCLTTKTSL WRKNANGGYV CNACGLYQKL HSTPRPLNII KQNNGEQIIR RRTRKRLNPE
ALQAEQLNKQ QRGGSEEQVN GSPLERRSED HLTEGHQREI PLPSLSKYEA QGSLTKSHSA
QQPVLVSQTL DIHKRMQPLH IQIKSPQEST GDPGNSSSVS EGKGSSERGS PIEKYMRPAK
HPNYSPPGSP IEKYQYPLFG LPFVHNDFQS EADWLRFWSK YKLSVPGNPH YLSHVPGLPN
PCQNYVPYPT FNLPPHFSAV GSDNDIPLDL AIKHSRPGPT ANGASKEKTK APSNVKSEGP
LNVVKTEKVD RSTQDELSTK CVHCGIVFLD EVMYALHMSC HGDSGPFQCS ICQHLCTDKY
DFTTHIQRGL HRNNAQAEKN GKPKE
//
