ID A0A8C7DSM1_NAJNA Unreviewed; 862 AA.
AC A0A8C7DSM1;
DT 19-JAN-2022, integrated into UniProtKB/TrEMBL.
DT 19-JAN-2022, sequence version 1.
DT 28-JAN-2026, entry version 20.
DE RecName: Full=phosphoribosylformylglycinamidine cyclo-ligase {ECO:0000256|ARBA:ARBA00013047};
DE EC=6.3.3.1 {ECO:0000256|ARBA:ARBA00013047};
OS Naja naja (Indian cobra).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC Serpentes; Colubroidea; Elapidae; Elapinae; Naja.
OX NCBI_TaxID=35670 {ECO:0000313|Ensembl:ENSNNAP00000009521.1, ECO:0000313|Proteomes:UP000694559};
RN [1] {ECO:0000313|Ensembl:ENSNNAP00000009521.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (AUG-2025) to UniProtKB.
RN [2] {ECO:0000313|Ensembl:ENSNNAP00000009521.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2025) to UniProtKB.
CC -!- PATHWAY: Purine metabolism; IMP biosynthesis via de novo pathway; 5-
CC amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-
CC phospho-D-ribosyl)glycinamide: step 2/2.
CC {ECO:0000256|ARBA:ARBA00004686}.
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DR AlphaFoldDB; A0A8C7DSM1; -.
DR Ensembl; ENSNNAT00000009984.1; ENSNNAP00000009521.1; ENSNNAG00000005957.1.
DR GeneTree; ENSGT00390000000292; -.
DR UniPathway; UPA00074; UER00129.
DR Proteomes; UP000694559; Unplaced.
DR GO; GO:0005829; C:cytosol; IEA:TreeGrafter.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0004637; F:phosphoribosylamine-glycine ligase activity; IEA:InterPro.
DR GO; GO:0004641; F:phosphoribosylformylglycinamidine cyclo-ligase activity; IEA:UniProtKB-EC.
DR GO; GO:0006189; P:'de novo' IMP biosynthetic process; IEA:UniProtKB-UniPathway.
DR GO; GO:0046084; P:adenine biosynthetic process; IEA:TreeGrafter.
DR CDD; cd02196; PurM; 1.
DR FunFam; 3.40.50.20:FF:000006; Phosphoribosylamine--glycine ligase, chloroplastic; 1.
DR Gene3D; 3.40.50.20; -; 1.
DR Gene3D; 3.40.50.170; Formyl transferase, N-terminal domain; 1.
DR Gene3D; 3.90.600.10; Phosphoribosylglycinamide synthetase, C-terminal domain; 1.
DR Gene3D; 3.90.650.10; PurM-like C-terminal domain; 1.
DR Gene3D; 3.30.1330.10; PurM-like, N-terminal domain; 1.
DR InterPro; IPR002376; Formyl_transf_N.
DR InterPro; IPR036477; Formyl_transf_N_sf.
DR InterPro; IPR016185; PreATP-grasp_dom_sf.
DR InterPro; IPR020560; PRibGlycinamide_synth_C-dom.
DR InterPro; IPR037123; PRibGlycinamide_synth_C_sf.
DR InterPro; IPR020562; PRibGlycinamide_synth_N.
DR InterPro; IPR010918; PurM-like_C_dom.
DR InterPro; IPR036676; PurM-like_C_sf.
DR InterPro; IPR016188; PurM-like_N.
DR InterPro; IPR036921; PurM-like_N_sf.
DR InterPro; IPR004733; PurM_cligase.
DR InterPro; IPR011054; Rudment_hybrid_motif.
DR PANTHER; PTHR10520:SF12; TRIFUNCTIONAL PURINE BIOSYNTHETIC PROTEIN ADENOSINE-3; 1.
DR PANTHER; PTHR10520; TRIFUNCTIONAL PURINE BIOSYNTHETIC PROTEIN ADENOSINE-3-RELATED; 1.
DR Pfam; PF00586; AIRS; 1.
DR Pfam; PF02769; AIRS_C; 1.
DR Pfam; PF00551; Formyl_trans_N; 1.
DR Pfam; PF02843; GARS_C; 1.
DR Pfam; PF02844; GARS_N; 1.
DR SMART; SM01210; GARS_C; 1.
DR SUPFAM; SSF53328; Formyltransferase; 1.
DR SUPFAM; SSF56059; Glutathione synthetase ATP-binding domain-like; 1.
DR SUPFAM; SSF52440; PreATP-grasp domain; 1.
DR SUPFAM; SSF56042; PurM C-terminal domain-like; 1.
DR SUPFAM; SSF55326; PurM N-terminal domain-like; 1.
DR SUPFAM; SSF51246; Rudiment single hybrid motif; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Ligase {ECO:0000256|ARBA:ARBA00022598};
KW Manganese {ECO:0000256|ARBA:ARBA00023211};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Purine biosynthesis {ECO:0000256|ARBA:ARBA00022755};
KW Reference proteome {ECO:0000313|Proteomes:UP000694559};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 182..204
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 245..334
FT /note="Phosphoribosylglycinamide synthetase C-domain"
FT /evidence="ECO:0000259|SMART:SM01210"
SQ SEQUENCE 862 AA; 94450 MW; C2D36CA022EF6F0A CRC64;
MADRVLVIGR GGREHALAWK LAQSPHLKQI LIAPGNAGTA DDGKMSNSGV LISNHTILSQ
FCKDHNIGCV IAGPETLLAA GIVDDLVAAG IPCFGPTAKA AQLGTNRYFT NIFLDQHGIP
TARWKAFSNP KEALAVLFIM QDNMCCHSGD SSDTVIIEEL LKGEEFSVCC FIKYLGQNHH
CLLGLLFILI TYSNVIIYVC VYVCTHQRWY SIILQLLKSD LYEVIQAAIG GQLCSSILAW
SDDCTAVSVS MENGSYLQGH KKSMEITGLL QANELGLEIF HGATIIKEGK VLSNGNRILT
ATAVKQDIMS ALEDIYKGLA VVSIQGATYG KETSCPGHDG FISAFFDLKA SGYRDPILVS
HAKGIGTKLK VAQLCNKHDM IGQDLVAICV NDLLVQGAEP LFFHGHFAFG KLDVGVAQLT
QAVSDGIVEA CKLAGCTFLG RETNEMPATC AAGEYNLVGF AVGAVERSMK FPQQGNIVIP
GGYGNHTLGE QLLTPTKIYS RALLPVARSG NVKAFIHIGW RIPTHHLYFL KKLISHTHKW
KIPSVFSWLQ EEGNLSEEEM GQIFNCGIGA VLIVQREAAR KVLKDVQKHE DAWMIGKVVH
RTAAYASSGY PQVEIKNLSE VLLQNKWPFL KDVSNADNPP HTIHRKHKVK VAVLISGTGT
SLSALLAYAK EPASCSEVVL VIANRSGVEE LRNATLAGIP TRVIDHKLYG SRSEYEGTID
SVLEEFSIEL ICLSGFIRIL SSNFLRKWYG KMLGTYPSVS PLSKRRNIYN QAHPSTDKIV
GCTVHFVLET SPEAIIVQEP VCVKAEDTQE TLYAKIKEAE NHVFPMALQL VASGMVQLRG
DGKTYWKRER QELICQKERQ DC
//
