ID A0A8C7GTP9_ONCKI Unreviewed; 1205 AA.
AC A0A8C7GTP9;
DT 19-JAN-2022, integrated into UniProtKB/TrEMBL.
DT 19-JAN-2022, sequence version 1.
DT 28-JAN-2026, entry version 17.
DE RecName: Full=Condensin complex subunit 1 {ECO:0000256|ARBA:ARBA00016064, ECO:0000256|PIRNR:PIRNR017127};
GN Name=NCAPD2 {ECO:0000313|Ensembl:ENSOKIP00005046306.1};
GN Synonyms=ncapd2 {ECO:0000313|Ensembl:ENSOKIP00005046306.1};
OS Oncorhynchus kisutch (Coho salmon) (Salmo kisutch).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC Salmonidae; Salmoninae; Oncorhynchus.
OX NCBI_TaxID=8019 {ECO:0000313|Ensembl:ENSOKIP00005046306.1, ECO:0000313|Proteomes:UP000694557};
RN [1] {ECO:0000313|Ensembl:ENSOKIP00005046306.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (AUG-2025) to UniProtKB.
RN [2] {ECO:0000313|Ensembl:ENSOKIP00005046306.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2025) to UniProtKB.
CC -!- FUNCTION: Regulatory subunit of the condensin complex, a complex
CC required for conversion of interphase chromatin into mitotic-like
CC condense chromosomes. The condensin complex probably introduces
CC positive supercoils into relaxed DNA in the presence of type I
CC topoisomerases and converts nicked DNA into positive knotted forms in
CC the presence of type II topoisomerases.
CC {ECO:0000256|PIRNR:PIRNR017127}.
CC -!- SUBCELLULAR LOCATION: Chromosome {ECO:0000256|ARBA:ARBA00004286}.
CC Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Nucleus
CC {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the CND1 (condensin subunit 1) family.
CC {ECO:0000256|ARBA:ARBA00009606, ECO:0000256|PIRNR:PIRNR017127}.
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DR AlphaFoldDB; A0A8C7GTP9; -.
DR Ensembl; ENSOKIT00005048801.1; ENSOKIP00005046306.1; ENSOKIG00005019394.1.
DR GeneTree; ENSGT00940000153566; -.
DR Proteomes; UP000694557; Unassembled WGS sequence.
DR GO; GO:0000779; C:condensed chromosome, centromeric region; IEA:TreeGrafter.
DR GO; GO:0000796; C:condensin complex; IEA:TreeGrafter.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0042393; F:histone binding; IEA:TreeGrafter.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR GO; GO:0010032; P:meiotic chromosome condensation; IEA:TreeGrafter.
DR GO; GO:0007076; P:mitotic chromosome condensation; IEA:InterPro.
DR FunFam; 1.25.10.10:FF:000695; Condensin complex subunit 1; 1.
DR FunFam; 1.25.10.10:FF:001828; Condensin complex subunit 1; 1.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 2.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR026971; CND1/NCAPD3.
DR InterPro; IPR032682; Cnd1_C.
DR InterPro; IPR007673; Condensin_cplx_su1.
DR InterPro; IPR024324; Condensin_cplx_su1_N.
DR PANTHER; PTHR14222; CONDENSIN; 1.
DR PANTHER; PTHR14222:SF2; CONDENSIN COMPLEX SUBUNIT 1; 1.
DR Pfam; PF12717; Cnd1; 1.
DR Pfam; PF12922; Cnd1_N; 1.
DR PIRSF; PIRSF017127; Condensin_D2; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
PE 3: Inferred from homology;
KW Cell cycle {ECO:0000256|ARBA:ARBA00023306, ECO:0000256|PIRNR:PIRNR017127};
KW Cell division {ECO:0000256|ARBA:ARBA00022618,
KW ECO:0000256|PIRNR:PIRNR017127}; Chromosome {ECO:0000256|ARBA:ARBA00022454};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW DNA condensation {ECO:0000256|ARBA:ARBA00023067,
KW ECO:0000256|PIRNR:PIRNR017127};
KW Mitosis {ECO:0000256|ARBA:ARBA00022776, ECO:0000256|PIRNR:PIRNR017127};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000694557}.
FT DOMAIN 27..179
FT /note="Condensin complex subunit 1 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF12922"
FT DOMAIN 921..1081
FT /note="Condensin complex subunit 1 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF12717"
FT REGION 803..826
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1153..1175
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 803..820
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1153..1162
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1205 AA; 133702 MW; 5B0477186471FD57 CRC64;
THDGILVPAS AHFSAEVLIR ISLRSLLVVS GLSVSLPSLL LNASLSAPDR KEQLNAVKMS
VFLLCKLTEI LESDSYRQSI VTAPSKGSKK GKAAGEGLLQ WDSERETVLQ ALTQLLQLDI
RSLWSLSLVE EEFISCVTCC CYKLLENPTI SHVKNKPTRD AIIHLLGVQV KKYNHLLGAS
VKVIQLLQHF EQLSSVCAQA VSVWSTEYGV KAIVGEVMRS IGQKSSEELA REGSGVKAFS
SFLSELGTLV PDTMIPNISV LLTHLEGESP SLRVAVCEVL GEVLVRVLSG DGLDESGRAD
RDRFMDTLQE HLHDTHSYVR ARVLQVYTRI VNSKALPLNR YSEVMGLAVG RLMDKSINVV
KSAIQLLAAF IAHNPYSCKL SSADLKKPLE KETDKLRELR ERLQENAPGK LYTPPFIFIF
SIMPNDETKA NVSQLKEGWD LSSRLAGNLG SVAEIGCSAV RSGLQCLGPD QDTSEIREDL
PSTPQKEGTE LKKQEMLLQY LKDTESFALQ VERAIAVINT MNECVSVVQE AVQFCVTVCE
FSVANSLTGV RKMLPLVWST DAAIKDAVVQ AYRRLYLNPQ GDNTRAKAQT LVDSLSELMV
DASLGTIQCL EEIVQEFFGG GSSLQSTVVQ VLWERFTGKR ETSSLHRRAA VLLLGMAREV
VLSNLDTLCS VALGEKLTED LLLARDSVIT ICNITDHQCK GAPFRLPQDN QLFTCLTQAI
AEGVVMADPH WQSFMEQAVR LLYFLSESPD QLCSRLLQRC SRLLLDQIAE VPAVSCVSLA
QLLSLCGCVA FWQVSHLERS VSTELRRRRG ETEEREEKAK QAANDSSVEE ELGLMGASAE
DTEAELIRKI CETELLAEEN LLCSFLPLLV RVCSSPGRYC HPQLTTAACL ALSQYMMISP
SVCEEHIRLL FTVLERSSLP VVRANAIIGL GDLTVRFPNI LEPWTQNLYT RLSDENPAVR
QTAVTVLTQL VLKDVLKVKG QVSEVAVLLI DPQTHIASLA LNFFNELASK DNAIYNLLPD
IISRLSDPER AMNEEDFHTI MKQLFSYITK ERQTESLVEK LCQRFRTAKT ERQWCDLAVS
LSLLSMCERG LKRLQEGWEC YSDKLTETGV YQPLLSITAK LRRGAKPQLK VQFKPPKKAL
SPLNSDIHNT LGTSQAKPSV SSCHDDSFMT PKPTRKSSKK AVITFSSDEE EEEEGICTVR
KCNLF
//
