ID A0A8C7HND4_ONCKI Unreviewed; 2352 AA.
AC A0A8C7HND4;
DT 19-JAN-2022, integrated into UniProtKB/TrEMBL.
DT 19-JAN-2022, sequence version 1.
DT 10-JUN-2026, entry version 21.
DE SubName: Full=Nuclear receptor corepressor 1 {ECO:0000313|Ensembl:ENSOKIP00005061134.1};
GN Name=NCOR1 {ECO:0000313|Ensembl:ENSOKIP00005061134.1};
GN Synonyms=LOC109892751 {ECO:0000313|Ensembl:ENSOKIP00005061134.1};
OS Oncorhynchus kisutch (Coho salmon) (Salmo kisutch).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC Salmonidae; Salmoninae; Oncorhynchus.
OX NCBI_TaxID=8019 {ECO:0000313|Ensembl:ENSOKIP00005061134.1, ECO:0000313|Proteomes:UP000694557};
RN [1] {ECO:0000313|Ensembl:ENSOKIP00005061134.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (AUG-2025) to UniProtKB.
RN [2] {ECO:0000313|Ensembl:ENSOKIP00005061134.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2025) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the N-CoR nuclear receptor corepressors family.
CC {ECO:0000256|ARBA:ARBA00010097}.
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DR Ensembl; ENSOKIT00005064965.1; ENSOKIP00005061134.1; ENSOKIG00005025038.1.
DR GeneTree; ENSGT00940000155093; -.
DR Proteomes; UP000694557; Unassembled WGS sequence.
DR GO; GO:0000785; C:chromatin; IEA:TreeGrafter.
DR GO; GO:0005654; C:nucleoplasm; IEA:UniProtKB-ARBA.
DR GO; GO:0032991; C:protein-containing complex; IEA:UniProtKB-ARBA.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0046966; F:nuclear thyroid hormone receptor binding; IEA:TreeGrafter.
DR GO; GO:0003714; F:transcription corepressor activity; IEA:TreeGrafter.
DR GO; GO:0006351; P:DNA-templated transcription; IEA:UniProtKB-KW.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IEA:UniProtKB-ARBA.
DR CDD; cd00167; SANT; 2.
DR FunFam; 1.10.10.60:FF:000026; Nuclear receptor corepressor 2 isoform 1; 1.
DR FunFam; 1.20.5.430:FF:000001; Nuclear receptor corepressor 2 isoform 1; 1.
DR Gene3D; 1.20.5.430; -; 1.
DR Gene3D; 1.20.58.1880; -; 1.
DR Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR InterPro; IPR009057; Homeodomain-like_sf.
DR InterPro; IPR051571; N-CoR_corepressor.
DR InterPro; IPR031557; N-CoR_GPS2_interact.
DR InterPro; IPR001005; SANT/Myb.
DR InterPro; IPR017884; SANT_dom.
DR PANTHER; PTHR13992; NUCLEAR RECEPTOR CO-REPRESSOR RELATED NCOR; 1.
DR PANTHER; PTHR13992:SF5; NUCLEAR RECEPTOR COREPRESSOR 1; 1.
DR Pfam; PF15784; GPS2_interact; 1.
DR Pfam; PF00249; Myb_DNA-binding; 2.
DR Pfam; PF27579; NCOR1_N; 1.
DR SMART; SM00717; SANT; 2.
DR SUPFAM; SSF46689; Homeodomain-like; 2.
DR PROSITE; PS51293; SANT; 2.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000694557};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Repressor {ECO:0000256|ARBA:ARBA00022491};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 397..448
FT /note="SANT"
FT /evidence="ECO:0000259|PROSITE:PS51293"
FT DOMAIN 560..595
FT /note="SANT"
FT /evidence="ECO:0000259|PROSITE:PS51293"
FT REGION 1..70
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 124..150
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 179..205
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 478..545
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 606..809
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 896..941
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1201..1221
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1235..1259
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1272..1306
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1368..1484
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1597..1726
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1755..1848
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1867..1890
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1942..1965
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1986..2334
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 263..290
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1..19
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 26..46
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 60..70
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 185..194
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 481..491
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 500..512
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 536..545
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 606..617
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 625..636
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 637..653
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 673..686
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 693..720
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 728..739
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 748..775
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 916..927
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1201..1210
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1397..1406
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1600..1609
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1630..1673
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1700..1724
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1764..1777
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1789..1802
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1829..1846
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1867..1876
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1943..1954
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1994..2005
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2006..2016
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2029..2049
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2053..2069
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2088..2097
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2157..2175
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2201..2233
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2244..2256
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2298..2318
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2352 AA; 261226 MW; 3A5B21D55D49B95E CRC64;
MSSSSGYPPT QGSFSSEQSR YPPHSVQYTF STTRHQQVRN CHLQDQQGRR RPSLLSEFHP
GTERPPERRH GYEQQFHSVT SQQQTDGHEA LEAKRPRMET VSEAHFSHNW IHFLSVFQET
QFSGMKAESQ SPGGLHRVGE EQDGSPSKLS KEELIQSMDR VDREIAKVEQ QIFKLKKKQQ
QLEEEAAKPV EPEKPATPPP IPQEHNKHRS IVQIIYDENR VGLPGNPVHL LYSYSNRFSL
SPSNQVMRKK LILFFKRRNH ARKQREQNIC QRYDQLMEAW EKKVERMENN PRRKAKDSRT
REYYERQFPE IRKQREQQER FQRVGQRGTG MSATIARSEH EISEIIDGLS EQENNEKQMR
QLSVIPPMMY DTEQRRVRFI NMNGLMDDPM KMYKARQFMN VWTEQEKAIF KEKFVQHPKN
FGLIASYLER KCVSDCVLYY YLTKKNQNYK TLVRRNYGRR RGRNQPCYGE VKPFGPISFR
DIGKDKDKCD GGEDEDGKEQ STPRGRKTAN SQGRRKGRIT TRSMANEAAS VATEEPLPPA
SAPEPVLPIP TQSLFSPLPG LVEHGRNWPA IAKMVGTKSE AQCKNFYFNY KRRHNLDNLL
QQHKQDIRRA RGDRDPSQSE SMASADDDEN PEDSEGGENS SDTESAPSPS QADPSKVGGE
SQRGDIAGGS ESQRSDQDQA SDRKGQDPSY GELRVKLEKS PEGEARDPDS QEDQDRERAR
AASYEGQVHP KCEPQEVDMK PGGTEVQVKV EPDSAKEKGD NGEREEQREG HHSDNDSSAT
CSADEDVDAE PERQRIFSSM DKPSLLSPPG SVLMSTAKQA HLNMQQFQQG AAAIPPMVSH
YSNPHFSMIR YAHSERQAYG GRQQGESMSC LDQPTRQVSK PFPYMPYDMK MALEQEAQSG
RPGSPYRLSP RDMSKASPQP NDPNASRYSV PPVLQPAPNQ VVQSLPDGVR VTFSRHSRPA
NIPSPPPLIP TSKPTDKPSF IQGGSISQGT PGTYLPSHAV YGGPEVAKSS VGSISLGLPR
QQDPTKPGKT MSYIKQEECS PRGQSEGLLS QMQYEGVVRG VCLFVDLTKV SACHPACPCL
PSVSPFTLSP KQCCYGTPAL SGSSIAADLL KGTNTKLATE ELSNPEKARE HLAKGHVIYE
GKSGHILSYD AIKNPREATC SPRSGHELKR SHDMMEATRG HPGREGAPFE GLIIRALPRE
SPHGESKERP MMTGSIMQGT PRTSAEAYEE SMKYGKQIKR ESPPIRSFEG GIGKGKPYEG
VNTIKEMGRS IHEIPRQEQP GQDPRKTPDM AANSRAAMEG SISQGHPLSQ SAIKHNVKSL
ITSPSRLPHG PTMPQLEAME RAKYEESKAT AEQQQRARHT SVVNSATSVL RSTHQEQGKS
QLSPGMYQDA DARRTPVNYS TSSMSRGSPM LGRGQEGMSC LTFPLKPTSH DRKSTMTPNQ
RDSIPAKSPV SGGDPNHPMA SHSPFDPHHR PMAPGEPRFH LPPHLDPTLF HRAVLDPAAY
MFPRQPSPTG YHNTYQLYTM ENTRQTILND YITSQQMQVI PRPDVARGLS PREQQQIAIS
YPPGARGIID LAQMPPTILL PHPGGTGTPT MDRITYIPGA QPPFPPRPFN PASISPGHQA
HLAATAAACQ ERERERERER EREHREKERE KERERENRER EREEYRQRER ERVVAAAVAN
DYMRPGQPDR PGSRGYLRSP SPSMRSQEAQ QQRPSIFQGT NSKGVITPLM PSAAAQAGAR
YSTAADALAA LVDAAASAPQ MDVNKGKDSS KHDRDDDMSS SSSSSAARRQ HEQQQQEADR
RSMQSPYMSL PGGKPHPGYA EGSGGPQGGK DKGPPTKSRI EEELRTRGKT TITAANFIDV
IIKRQIASDK DSRERGSQSS DSSSSWVVLP PPSTLPDISP SSIPIYHFSL PFLYPPQLSL
VTVCYPHSAA GMRSFDMIRY RQSAESQQPP SSQADGGYSQ SQQVPKTHRV MTLADHISHI
ITQDFARNQD PPQSSTTISS SATTTFQSAQ LPVSSSGPGG RAKGHSRYSP ENQTQAPSHH
QRPTPSRVSP ENAPDKPRAR PGKSPDRGGR GAVESYEPIS PPQSYQDKQQ EAREQQGDSR
SPGSVSYLPS FFTKLENTSP MVKSKKQEIF RKLNSSGVGD SDVGNAQPGT EIFNLPAVTS
SSSVNPRNHS FSDPASNLGL EDIIRKALMG NLEERPEEHQ GGSQPSCNTP SNEARQEANP
SPSMGKQKLQ SKANSRKSKS PNPGQAYAAA AQAAGGERPS SVSSVHSEGD YHQQATGWAW
EDRPSSTGSM QFPYNPLTMR MMSSTPPTSM ASPSMQAQQP PPGGPLGSQQ QRVWEREPLL
SEQYETLSDS DD
//
