ID A0A8C7KSS7_ONCKI Unreviewed; 320 AA.
AC A0A8C7KSS7;
DT 19-JAN-2022, integrated into UniProtKB/TrEMBL.
DT 19-JAN-2022, sequence version 1.
DT 28-JAN-2026, entry version 18.
DE RecName: Full=Bardet-Biedl syndrome 5 protein homolog {ECO:0000256|PIRNR:PIRNR010072};
GN Name=BBS5 {ECO:0000313|Ensembl:ENSOKIP00005102020.1};
GN Synonyms=bbs5 {ECO:0000313|Ensembl:ENSOKIP00005102020.1};
OS Oncorhynchus kisutch (Coho salmon) (Salmo kisutch).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC Salmonidae; Salmoninae; Oncorhynchus.
OX NCBI_TaxID=8019 {ECO:0000313|Ensembl:ENSOKIP00005102020.1, ECO:0000313|Proteomes:UP000694557};
RN [1] {ECO:0000313|Ensembl:ENSOKIP00005102020.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (AUG-2025) to UniProtKB.
RN [2] {ECO:0000313|Ensembl:ENSOKIP00005102020.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2025) to UniProtKB.
CC -!- FUNCTION: Required for ciliogenesis. {ECO:0000256|PIRNR:PIRNR010072}.
CC -!- SUBCELLULAR LOCATION: Cell projection, cilium membrane
CC {ECO:0000256|ARBA:ARBA00004309, ECO:0000256|PIRNR:PIRNR010072}.
CC Cytoplasm, cytoskeleton, microtubule organizing center, centrosome,
CC centriolar satellite {ECO:0000256|ARBA:ARBA00004607}.
CC -!- SIMILARITY: Belongs to the BBS5 family. {ECO:0000256|ARBA:ARBA00005822,
CC ECO:0000256|PIRNR:PIRNR010072}.
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DR RefSeq; XP_031662002.1; XM_031806142.1.
DR RefSeq; XP_031662003.1; XM_031806143.1.
DR AlphaFoldDB; A0A8C7KSS7; -.
DR Ensembl; ENSOKIT00005109305.1; ENSOKIP00005102020.1; ENSOKIG00005044863.1.
DR GeneID; 109871386; -.
DR GeneTree; ENSGT00390000002753; -.
DR Proteomes; UP000694557; Unassembled WGS sequence.
DR GO; GO:0034464; C:BBSome; IEA:UniProtKB-UniRule.
DR GO; GO:0034451; C:centriolar satellite; IEA:UniProtKB-SubCell.
DR GO; GO:0036064; C:ciliary basal body; IEA:TreeGrafter.
DR GO; GO:0060170; C:ciliary membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0032266; F:phosphatidylinositol-3-phosphate binding; IEA:TreeGrafter.
DR GO; GO:0060271; P:cilium assembly; IEA:TreeGrafter.
DR FunFam; 2.30.29.30:FF:000232; Bardet-Biedl syndrome 5 isoform 1; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR006606; BBL5.
DR InterPro; IPR030804; BBS5/fem-3.
DR InterPro; IPR014003; BBS5_PH.
DR InterPro; IPR011993; PH-like_dom_sf.
DR PANTHER; PTHR21351:SF0; BARDET-BIEDL SYNDROME 5 PROTEIN; 1.
DR PANTHER; PTHR21351; BARDET-BIEDL SYNDROME PROTEIN 5; 1.
DR Pfam; PF07289; BBL5; 1.
DR PIRSF; PIRSF010072; DUF1448; 1.
DR SMART; SM00683; DM16; 2.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475,
KW ECO:0000256|PIRNR:PIRNR010072};
KW Cell projection {ECO:0000256|ARBA:ARBA00023273,
KW ECO:0000256|PIRNR:PIRNR010072};
KW Cilium {ECO:0000256|ARBA:ARBA00023069, ECO:0000256|PIRNR:PIRNR010072};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490, ECO:0000256|PIRNR:PIRNR010072};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212,
KW ECO:0000256|PIRNR:PIRNR010072};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|PIRNR:PIRNR010072};
KW Reference proteome {ECO:0000313|Proteomes:UP000694557}.
FT DOMAIN 7..61
FT /note="BBSome complex member BBS5 PH"
FT /evidence="ECO:0000259|SMART:SM00683"
FT DOMAIN 137..191
FT /note="BBSome complex member BBS5 PH"
FT /evidence="ECO:0000259|SMART:SM00683"
SQ SEQUENCE 320 AA; 36380 MW; 4F6828639586A6CF CRC64;
MKTRPGEVLI DCLDSIEDTK GNNGDRGRLL VTNLRIIWHS LALPRVNLSV GYNSIINITT
RTANSKLRGQ TEALYILTKS NNTRFEFIFT NVVPGSPRLF TSVIAVHRAY ETSKMYRDLK
LRGALIQNKQ LRLLPREEVY DKINGVWNLS SDQGNLGTFF ITNVRIVWHA NMNESFNVSI
PYLQIRSIRI RDSKFGLALV IESSQQTGGY VLGFKIDPMD KLQDAVKEIN SLHKVYSANP
IFGVDYEMEE KPQPLEELTV DQPPDDVEIE PDEQTDAFTA YFADGNKQQD REPMFSEELG
IAVEKLKEGF TLQGLWEVMG
//
