ID A0A8C7MBW9_ONCKI Unreviewed; 280 AA.
AC A0A8C7MBW9;
DT 19-JAN-2022, integrated into UniProtKB/TrEMBL.
DT 19-JAN-2022, sequence version 1.
DT 28-JAN-2026, entry version 18.
DE SubName: Full=Insulin-like growth factor binding protein 2b {ECO:0000313|Ensembl:ENSOKIP00005043300.1};
GN Name=IGFBP2 {ECO:0000313|Ensembl:ENSOKIP00005043300.1};
GN Synonyms=LOC109871277 {ECO:0000313|Ensembl:ENSOKIP00005043300.1};
OS Oncorhynchus kisutch (Coho salmon) (Salmo kisutch).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC Salmonidae; Salmoninae; Oncorhynchus.
OX NCBI_TaxID=8019 {ECO:0000313|Ensembl:ENSOKIP00005043300.1, ECO:0000313|Proteomes:UP000694557};
RN [1] {ECO:0000313|Ensembl:ENSOKIP00005043300.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (AUG-2025) to UniProtKB.
RN [2] {ECO:0000313|Ensembl:ENSOKIP00005043300.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2025) to UniProtKB.
CC -!- FUNCTION: IGF-binding proteins prolong the half-life of the IGFs and
CC have been shown to either inhibit or stimulate the growth promoting
CC effects of the IGFs on cell culture. They alter the interaction of IGFs
CC with their cell surface receptors. {ECO:0000256|ARBA:ARBA00003811}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00500}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR AlphaFoldDB; A0A8C7MBW9; -.
DR Ensembl; ENSOKIT00005045629.1; ENSOKIP00005043300.1; ENSOKIG00005018263.1.
DR GeneTree; ENSGT00940000158542; -.
DR Proteomes; UP000694557; Unassembled WGS sequence.
DR GO; GO:0005615; C:extracellular space; IEA:TreeGrafter.
DR GO; GO:0031994; F:insulin-like growth factor I binding; IEA:UniProtKB-ARBA.
DR GO; GO:0031995; F:insulin-like growth factor II binding; IEA:TreeGrafter.
DR GO; GO:0048640; P:negative regulation of developmental growth; IEA:UniProtKB-ARBA.
DR GO; GO:0043567; P:regulation of insulin-like growth factor receptor signaling pathway; IEA:TreeGrafter.
DR CDD; cd00191; TY; 1.
DR FunFam; 4.10.40.20:FF:000001; Insulin-like growth factor binding protein 5; 1.
DR FunFam; 4.10.800.10:FF:000002; Insulin-like growth factor-binding protein 2; 1.
DR Gene3D; 4.10.40.20; -; 1.
DR Gene3D; 4.10.800.10; Thyroglobulin type-1; 1.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR012210; IGFBP-2.
DR InterPro; IPR000867; IGFBP-like.
DR InterPro; IPR022321; IGFBP_1-6_chordata.
DR InterPro; IPR000716; Thyroglobulin_1.
DR InterPro; IPR036857; Thyroglobulin_1_sf.
DR PANTHER; PTHR11551; INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN; 1.
DR PANTHER; PTHR11551:SF5; INSULIN-LIKE GROWTH FACTOR-BINDING PROTEIN 2; 1.
DR Pfam; PF00219; IGFBP; 1.
DR Pfam; PF00086; Thyroglobulin_1; 1.
DR PRINTS; PR01976; IGFBPFAMILY.
DR PRINTS; PR01978; IGFBPFAMILY2.
DR SMART; SM00121; IB; 1.
DR SMART; SM00211; TY; 1.
DR SUPFAM; SSF57184; Growth factor receptor domain; 1.
DR SUPFAM; SSF57610; Thyroglobulin type-1 domain; 1.
DR PROSITE; PS51323; IGFBP_N_2; 1.
DR PROSITE; PS51162; THYROGLOBULIN_1_2; 1.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Growth factor binding {ECO:0000256|ARBA:ARBA00023183};
KW Growth regulation {ECO:0000256|ARBA:ARBA00022604};
KW Reference proteome {ECO:0000313|Proteomes:UP000694557};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..23
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 24..280
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5034484704"
FT DOMAIN 25..106
FT /note="IGFBP N-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51323"
FT DOMAIN 174..256
FT /note="Thyroglobulin type-1"
FT /evidence="ECO:0000259|PROSITE:PS51162"
FT REGION 108..177
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 108..117
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 280 AA; 31335 MW; 0D91E4203589A085 CRC64;
MVLYYGCSLL LLTFLALPGL LLGGVVFHCP SCAAERQAAC PKLATTCTEI VREPGCGCCP
VCSRLEGEFC GIYTPRCSTG LHCYPTADSE LPLEQLVQGS GRCSHNLTQE HQDKSGSIEE
LQGTEGPPQK KPTKDASPWM WSKQKALRQA QNELKTKMKT NTRPEEPRTQ RATQSHCQQE
MDKVLEEISK MTFHDNREPL EDLYELNFPN CDRRGQYNLK QCHMSTHGQR GECWCVNPFT
GVQITQSTRV RGDPKCSQYV EEQEMATGTL PTVVLPMAET
//
