ID A0A8C7XDG0_9TELE Unreviewed; 1128 AA.
AC A0A8C7XDG0;
DT 19-JAN-2022, integrated into UniProtKB/TrEMBL.
DT 19-JAN-2022, sequence version 1.
DT 10-JUN-2026, entry version 21.
DE RecName: Full=Rho GTPase-activating protein 20 {ECO:0000256|ARBA:ARBA00070254};
DE AltName: Full=Rho-type GTPase-activating protein 20 {ECO:0000256|ARBA:ARBA00083374};
OS Oryzias sinensis (Chinese medaka).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=183150 {ECO:0000313|Ensembl:ENSOSIP00000011925.1, ECO:0000313|Proteomes:UP000694383};
RN [1] {ECO:0000313|Ensembl:ENSOSIP00000011925.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (JAN-2026) to UniProtKB.
CC -!- FUNCTION: GTPase activator for the Rho-type GTPases by converting them
CC to an inactive GDP-bound state. {ECO:0000256|ARBA:ARBA00055252}.
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DR AlphaFoldDB; A0A8C7XDG0; -.
DR Ensembl; ENSOSIT00000012647.1; ENSOSIP00000011925.1; ENSOSIG00000006934.1.
DR GeneTree; ENSGT00940000154633; -.
DR Proteomes; UP000694383; Unplaced.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR GO; GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd13319; PH_RARhoGAP; 1.
DR CDD; cd17115; RA_RHG20; 1.
DR CDD; cd04402; RhoGAP_ARHGAP20; 1.
DR FunFam; 2.30.29.30:FF:000217; Rho GTPase activating protein 20; 1.
DR FunFam; 1.10.555.10:FF:000025; Rho GTPase-activating protein 20; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR InterPro; IPR047886; ARHGAP20-like_RhoGAP.
DR InterPro; IPR047887; ARHGAP20_PH.
DR InterPro; IPR047888; ARHGAP20_RA.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR000159; RA_dom.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR23179:SF28; RHO GTPASE-ACTIVATING PROTEIN 20; 1.
DR PANTHER; PTHR23179; T-CELL ACTIVATION RHO GTPASE ACTIVATING PROTEIN-RELATED; 1.
DR Pfam; PF00788; RA; 1.
DR Pfam; PF22286; RHG20_PH; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 1.
DR PROSITE; PS50200; RA; 1.
DR PROSITE; PS50238; RHOGAP; 1.
PE 4: Predicted;
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468, ECO:0000256|PROSITE-
KW ProRule:PRU00172}; Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000694383}.
FT DOMAIN 195..317
FT /note="Ras-associating"
FT /evidence="ECO:0000259|PROSITE:PS50200"
FT DOMAIN 371..559
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT REGION 1..26
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 574..675
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 731..793
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 807..906
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1009..1028
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..21
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 574..584
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 585..594
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 595..604
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 612..623
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 658..668
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 731..749
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 769..793
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 827..841
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 866..906
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1128 AA; 124491 MW; 033000C3A024D43E CRC64;
METMTPLQGT MGQQRSESLT GENKYLPENK KKMKTLAQRR QSAPSLVISK ALTRSRSTSR
ETCSMPVSPE SCSLVQGFLA ESAGRLFLGH AQTQLKTGLQ TQERHFFLFN DTLLVAKAKS
QTHFKVKSQV RVCEMWTANC MEEVCEGSTN PDRSFVMGWP TCNYVATFSS EELKDKWLAL
INGRISEGKE KDDPKTVPLK IFAKDIGNCA YAKTLAVNNT DTTTDVIRMS LQQFGISSCI
KDLRLWVNSS KDDPPYPLIG HEFPFCIKMS HIRDGGSCPG GIGRDPMSPT DCPGVLLLDQ
CLPPDTQCQF ILKPNKVLLS PQELLEPGQH KTFKRKRSLI NWPFWRGSSS QLDGLPLSPT
FSAAQGRLFG RPLSSVCSAD HGLPKPVMDM LVFLYLEGPY TKGVFRRSAG AKACRELRDR
LDNGTDNPDI KHQPVFVIAA VLKDFLRNIP GSLLCADLYD QWMDTMEQEG EDQKMEAIQR
LLPLLPAENL LLLRHLIAVL HCIQGNAQEN QMNAFNLAVC IAPSILCPPA PSTPEMEGEA
TKKVCELVHF LIENCSGILG DVTSLFRAFC QKSSGSDHGS DVSSFQMNDS SYDSLENELN
DDPESPYQEQ LPLRDKDKPD SCSRDSVITL SDGDPDPDHD SELTLQLPPQ ARPRKFSPAA
RQPRARQANC SLQGPRRLRR CSEPALVLAP TASLNSTVAL GETRHQPVRK ASYDASMEGE
GEEDEVFLEQ ELGRLHLKEE GRDGSEKKAA KVSTCGKRKA KPAPPPPLRL DASCSSLSSP
ATSPTGSSLS SLDSAFSQYS TDYTVKWPVS QQSPRDSPPQ REATPHLQPS SHPQPTNQTA
SHGLHPNTWL KRDRRLSLKQ SEDGQSEGSS VGNGTSLLAN NGHSAANQEA GTVKQNCHQR
SGSPPSYHQA LLQLQRNRTP FYRGTEKAPT VKELRQLHDP PATYRTSKPT SPNNLKLLQS
EGAQRLAGTG KHVQPPKGIF FGQNATTLIL QRSKSHSLTP PMDVHKLSKT LPRRASEPAK
VSADSHHSTS LTLDRLPAFK AKCQDARLGL ADSEPHRSAS PFCLSSSSAR AVRDYFCSQG
QADPEACLRR SQEVVVAIVQ GKEWQSKRCS DPPMEDFEQL FFAEESYV
//
