ID   A0A8C7Z5L9_9TELE        Unreviewed;       561 AA.
AC   A0A8C7Z5L9;
DT   19-JAN-2022, integrated into UniProtKB/TrEMBL.
DT   19-JAN-2022, sequence version 1.
DT   28-JAN-2026, entry version 21.
DE   SubName: Full=Suppressor of cytokine signaling 5b {ECO:0000313|Ensembl:ENSOSIP00000036047.1};
OS   Oryzias sinensis (Chinese medaka).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC   Oryzias.
OX   NCBI_TaxID=183150 {ECO:0000313|Ensembl:ENSOSIP00000036047.1, ECO:0000313|Proteomes:UP000694383};
RN   [1] {ECO:0000313|Ensembl:ENSOSIP00000036047.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (AUG-2025) to UniProtKB.
RN   [2] {ECO:0000313|Ensembl:ENSOSIP00000036047.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2025) to UniProtKB.
CC   -!- PATHWAY: Protein modification; protein ubiquitination.
CC       {ECO:0000256|ARBA:ARBA00004906}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   AlphaFoldDB; A0A8C7Z5L9; -.
DR   Ensembl; ENSOSIT00000038003.1; ENSOSIP00000036047.1; ENSOSIG00000017951.1.
DR   GeneTree; ENSGT00940000164285; -.
DR   UniPathway; UPA00143; -.
DR   Proteomes; UP000694383; Unplaced.
DR   GO; GO:0005942; C:phosphatidylinositol 3-kinase complex; IEA:TreeGrafter.
DR   GO; GO:0046935; F:1-phosphatidylinositol-3-kinase regulator activity; IEA:TreeGrafter.
DR   GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR   GO; GO:0009968; P:negative regulation of signal transduction; IEA:UniProtKB-KW.
DR   GO; GO:0046854; P:phosphatidylinositol phosphate biosynthetic process; IEA:TreeGrafter.
DR   GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR   FunFam; 3.30.505.10:FF:000028; Suppressor of cytokine signaling 5; 1.
DR   Gene3D; 3.30.505.10; SH2 domain; 1.
DR   InterPro; IPR000980; SH2.
DR   InterPro; IPR036860; SH2_dom_sf.
DR   InterPro; IPR022252; SOCS4/SOCS5_dom.
DR   InterPro; IPR001496; SOCS_box.
DR   InterPro; IPR036036; SOCS_box-like_dom_sf.
DR   PANTHER; PTHR10155; PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT; 1.
DR   PANTHER; PTHR10155:SF15; SUPPRESSOR OF CYTOKINE SIGNALING 5; 1.
DR   Pfam; PF00017; SH2; 1.
DR   Pfam; PF12610; SOCS; 1.
DR   Pfam; PF07525; SOCS_box; 1.
DR   SMART; SM00252; SH2; 1.
DR   SMART; SM00253; SOCS; 1.
DR   SMART; SM00969; SOCS_box; 1.
DR   SUPFAM; SSF55550; SH2 domain; 1.
DR   SUPFAM; SSF158235; SOCS box-like; 1.
DR   PROSITE; PS50001; SH2; 1.
DR   PROSITE; PS50225; SOCS; 1.
PE   4: Predicted;
KW   Growth regulation {ECO:0000256|ARBA:ARBA00022604};
KW   Reference proteome {ECO:0000313|Proteomes:UP000694383};
KW   SH2 domain {ECO:0000256|ARBA:ARBA00022999, ECO:0000256|PROSITE-
KW   ProRule:PRU00191};
KW   Signal transduction inhibitor {ECO:0000256|ARBA:ARBA00022700};
KW   Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786}.
FT   DOMAIN          405..500
FT                   /note="SH2"
FT                   /evidence="ECO:0000259|PROSITE:PS50001"
FT   DOMAIN          495..544
FT                   /note="SOCS box"
FT                   /evidence="ECO:0000259|PROSITE:PS50225"
FT   REGION          92..153
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          240..323
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          360..380
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        264..274
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   561 AA;  62146 MW;  3350B24623A0971D CRC64;
     MKKVGNMWSN LKSRCQTLFH SSGPSESRVE ADAVHCVVDL GEGNGLAEAP GPRASSPSWG
     FLPVPVVSTG RRHHNCVSDI PQIVEITVDK ETEDARGGTG GIPLARRDSY SRHAPWGGKK
     KHSCSTKTQS SLETERRSGR LRGSGNRRDR RYGISSIQEI NDSVGGGRSL NTRSLRQRLS
     DTVGLCLPLP ARRCSRSSKN PVTSKRKIHL TELMLETCPF PPGSDLAHKW HLIKQHTAPV
     SPHSSTTLLD AFDPTHPSPE DEEERLRERR RLSIEEGVDP PPNAQIHTLE ASVPGSSLYK
     LGPKMTPGMG EASGEGRANG AGNSLGAASS GTCGQVLGAT ASAQDCDSEE DSTTLCLQAR
     RPKQRHASGE GHPSRQQHGP WKVHTQIDYI HCLVPDLLPI TTLPCYWGVM DRYEAEALLD
     GRPEGTFLLR DSAQEDYLFS VSFRRYNRSL HARIEQWNHN FSFDAHDPCV FHSSTVTGLL
     EHYKDPSACM FFEPLLTAPL NRTFPFSLQH LARAAICCWT TYDGIGSLPL PPALQDFLKE
     YHYKQKVRVR WLEREPPPKV K
//