ID A0A8C8WG06_PANLE Unreviewed; 272 AA.
AC A0A8C8WG06;
DT 19-JAN-2022, integrated into UniProtKB/TrEMBL.
DT 19-JAN-2022, sequence version 1.
DT 28-JAN-2026, entry version 17.
DE SubName: Full=F-box protein 5 {ECO:0000313|Ensembl:ENSPLOP00000003013.1};
GN Name=FBXO5 {ECO:0000313|Ensembl:ENSPLOP00000003013.1};
OS Panthera leo (Lion).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Pantherinae;
OC Panthera.
OX NCBI_TaxID=9689 {ECO:0000313|Ensembl:ENSPLOP00000003013.1, ECO:0000313|Proteomes:UP000694399};
RN [1] {ECO:0000313|Ensembl:ENSPLOP00000003013.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Armstrong E.E., Taylor R.W., Miller D.E., Kaelin C., Barsh G., Hadly E.A.,
RA Petrov D.;
RT "Long live the king: chromosome-level assembly of the lion (Panthera leo)
RT using linked-read, Hi-C, and long read data.";
RL bioRxiv 0:0-0(2019).
RN [2] {ECO:0000313|Ensembl:ENSPLOP00000003013.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (AUG-2025) to UniProtKB.
RN [3] {ECO:0000313|Ensembl:ENSPLOP00000003013.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2025) to UniProtKB.
CC -!- SIMILARITY: Belongs to the prokaryotic/mitochondrial release factor
CC family. {ECO:0000256|ARBA:ARBA00010835}.
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DR AlphaFoldDB; A0A8C8WG06; -.
DR Ensembl; ENSPLOT00000003306.1; ENSPLOP00000003013.1; ENSPLOG00000002097.1.
DR GeneTree; ENSGT00940000155683; -.
DR Proteomes; UP000694399; Chromosome B3.
DR GO; GO:0005739; C:mitochondrion; IEA:TreeGrafter.
DR GO; GO:0003747; F:translation release factor activity; IEA:InterPro.
DR GO; GO:0070126; P:mitochondrial translational termination; IEA:TreeGrafter.
DR FunFam; 3.30.70.1660:FF:000011; Peptide chain release factor 1-like, mitochondrial; 1.
DR Gene3D; 3.30.70.1660; -; 1.
DR Gene3D; 6.10.140.1950; -; 1.
DR InterPro; IPR005139; PCRF.
DR InterPro; IPR000352; Pep_chain_release_fac_I.
DR InterPro; IPR045853; Pep_chain_release_fac_I_sf.
DR InterPro; IPR050057; Prokaryotic/Mito_RF.
DR PANTHER; PTHR43804; LD18447P; 1.
DR PANTHER; PTHR43804:SF3; PEPTIDE CHAIN RELEASE FACTOR 1-LIKE, MITOCHONDRIAL; 1.
DR Pfam; PF03462; PCRF; 1.
DR Pfam; PF00472; RF-1; 1.
DR SMART; SM00937; PCRF; 1.
DR SUPFAM; SSF75620; Release factor; 1.
DR PROSITE; PS00745; RF_PROK_I; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917};
KW Reference proteome {ECO:0000313|Proteomes:UP000694399}.
FT DOMAIN 245..261
FT /note="Prokaryotic-type class I peptide chain release
FT factors"
FT /evidence="ECO:0000259|PROSITE:PS00745"
FT COILED 71..113
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 272 AA; 30619 MW; 8A27B561979043FC CRC64;
MRSRLLFSAA RCLRAFRAIS PARRHLKCGS LPLEELFAPG GPLRTFLERR ARCEAQLQFG
GSELLAVAKL LSDKEQELQE TEHLLHDENE DLRKLAENEI TSCQKQITQL KHQIILLLVP
SEETDENDLI LEVTAGVGGQ EAMLFTSEMF DMYQQYAAFK RWHFETLEYF PSEIGGLRHA
SASIGGVEAY KHLKFEGGVH RVQRVPKTEK QGRIHTSTMT VAILPQPTEI NLVINPKDLR
IDTKRASGAG GQHVNTTDSA VRIVHLPTGW NQ
//
