ID A0A8C9D5F0_PANLE Unreviewed; 1012 AA.
AC A0A8C9D5F0;
DT 19-JAN-2022, integrated into UniProtKB/TrEMBL.
DT 19-JAN-2022, sequence version 1.
DT 28-JAN-2026, entry version 21.
DE RecName: Full=Ephrin type-B receptor 6 {ECO:0000256|ARBA:ARBA00070274};
DE AltName: Full=Tyrosine-protein kinase-defective receptor EPH-6 {ECO:0000256|ARBA:ARBA00077388};
GN Name=EPHB6 {ECO:0000313|Ensembl:ENSPLOP00000015775.1};
OS Panthera leo (Lion).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Pantherinae;
OC Panthera.
OX NCBI_TaxID=9689 {ECO:0000313|Ensembl:ENSPLOP00000015775.1, ECO:0000313|Proteomes:UP000694399};
RN [1] {ECO:0000313|Ensembl:ENSPLOP00000015775.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Armstrong E.E., Taylor R.W., Miller D.E., Kaelin C., Barsh G., Hadly E.A.,
RA Petrov D.;
RT "Long live the king: chromosome-level assembly of the lion (Panthera leo)
RT using linked-read, Hi-C, and long read data.";
RL bioRxiv 0:0-0(2019).
RN [2] {ECO:0000313|Ensembl:ENSPLOP00000015775.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (AUG-2025) to UniProtKB.
RN [3] {ECO:0000313|Ensembl:ENSPLOP00000015775.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2025) to UniProtKB.
CC -!- FUNCTION: Kinase-defective receptor for members of the ephrin-B family.
CC Binds to ephrin-B1 and ephrin-B2. Modulates cell adhesion and migration
CC by exerting both positive and negative effects upon stimulation with
CC ephrin-B2. Inhibits JNK activation, T-cell receptor-induced IL-2
CC secretion and CD25 expression upon stimulation with ephrin-B2.
CC {ECO:0000256|ARBA:ARBA00059300}.
CC -!- SUBUNIT: Interacts with CBL and EPHB1. Interacts with FYN; this
CC interaction takes place in a ligand-independent manner.
CC {ECO:0000256|ARBA:ARBA00062552}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
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DR AlphaFoldDB; A0A8C9D5F0; -.
DR Ensembl; ENSPLOT00000017467.1; ENSPLOP00000015775.1; ENSPLOG00000011477.1.
DR GeneTree; ENSGT00940000160399; -.
DR OMA; PQGPSCM; -.
DR Proteomes; UP000694399; Chromosome A3.
DR GO; GO:0009986; C:cell surface; IEA:Ensembl.
DR GO; GO:0030425; C:dendrite; IEA:TreeGrafter.
DR GO; GO:0005886; C:plasma membrane; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0005005; F:transmembrane-ephrin receptor activity; IEA:TreeGrafter.
DR GO; GO:0050798; P:activated T cell proliferation; IEA:Ensembl.
DR GO; GO:0007411; P:axon guidance; IEA:TreeGrafter.
DR GO; GO:2000525; P:positive regulation of T cell costimulation; IEA:Ensembl.
DR GO; GO:0001806; P:type IV hypersensitivity; IEA:Ensembl.
DR CDD; cd10475; EphR_LBD_B6; 1.
DR CDD; cd00063; FN3; 2.
DR CDD; cd00185; TNFRSF; 1.
DR FunFam; 2.10.50.10:FF:000001; Ephrin type-A receptor 5; 1.
DR FunFam; 2.60.40.10:FF:000059; Ephrin type-A receptor 6; 1.
DR FunFam; 1.10.150.50:FF:000068; Ephrin type-B receptor 6; 1.
DR FunFam; 1.10.510.10:FF:000470; Ephrin type-B receptor 6; 1.
DR FunFam; 2.60.120.260:FF:000064; Ephrin type-B receptor 6; 1.
DR FunFam; 2.60.40.10:FF:000508; ephrin type-B receptor 6; 1.
DR FunFam; 2.60.40.1770:FF:000004; ephrin type-B receptor 6; 1.
DR FunFam; 3.30.200.20:FF:000143; Ephrin type-B receptor 6; 1.
DR Gene3D; 2.60.40.1770; ephrin a2 ectodomain; 1.
DR Gene3D; 2.60.120.260; Galactose-binding domain-like; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 2.
DR Gene3D; 3.30.200.20; Phosphorylase Kinase, domain 1; 1.
DR Gene3D; 1.10.150.50; Transcription Factor, Ets-1; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR Gene3D; 2.10.50.10; Tumor Necrosis Factor Receptor, subunit A, domain 2; 1.
DR InterPro; IPR027936; Eph_TM.
DR InterPro; IPR001090; Ephrin_rcpt_lig-bd_dom.
DR InterPro; IPR050449; Ephrin_rcpt_TKs.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR008979; Galactose-bd-like_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR001660; SAM.
DR InterPro; IPR013761; SAM/pointed_sf.
DR InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR InterPro; IPR011641; Tyr-kin_ephrin_A/B_rcpt-like.
DR InterPro; IPR016257; Tyr_kinase_ephrin_rcpt.
DR InterPro; IPR001426; Tyr_kinase_rcpt_V_CS.
DR PANTHER; PTHR46877; EPH RECEPTOR A5; 1.
DR PANTHER; PTHR46877:SF15; EPHRIN TYPE-B RECEPTOR 6; 1.
DR Pfam; PF14575; EphA2_TM; 1.
DR Pfam; PF25599; Ephrin_CRD; 1.
DR Pfam; PF01404; Ephrin_lbd; 1.
DR Pfam; PF07699; Ephrin_rec_like; 1.
DR Pfam; PF00041; fn3; 1.
DR Pfam; PF07714; PK_Tyr_Ser-Thr; 1.
DR Pfam; PF07647; SAM_2; 1.
DR PIRSF; PIRSF000666; TyrPK_ephrin_receptor; 1.
DR PRINTS; PR00014; FNTYPEIII.
DR PRINTS; PR00109; TYRKINASE.
DR SMART; SM00615; EPH_lbd; 1.
DR SMART; SM01411; Ephrin_rec_like; 1.
DR SMART; SM00060; FN3; 2.
DR SMART; SM00454; SAM; 1.
DR SUPFAM; SSF49265; Fibronectin type III; 1.
DR SUPFAM; SSF49785; Galactose-binding domain-like; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR SUPFAM; SSF47769; SAM/Pointed domain; 1.
DR PROSITE; PS51550; EPH_LBD; 1.
DR PROSITE; PS50853; FN3; 2.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00790; RECEPTOR_TYR_KIN_V_1; 1.
DR PROSITE; PS00791; RECEPTOR_TYR_KIN_V_2; 1.
DR PROSITE; PS50105; SAM_DOMAIN; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PIRSR:PIRSR000666-
KW 2}; Disulfide bond {ECO:0000256|PIRSR:PIRSR000666-3};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|PIRSR:PIRSR000666-2}; Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000694399};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..31
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 32..1012
FT /note="Ephrin type-B receptor 6"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5034235920"
FT TRANSMEM 586..610
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 33..228
FT /note="Eph LBD"
FT /evidence="ECO:0000259|PROSITE:PS51550"
FT DOMAIN 360..477
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 478..573
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 661..910
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT DOMAIN 939..1003
FT /note="SAM"
FT /evidence="ECO:0000259|PROSITE:PS50105"
FT BINDING 667..675
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PIRSR:PIRSR000666-2"
FT DISULFID 75..210
FT /evidence="ECO:0000256|PIRSR:PIRSR000666-3"
FT DISULFID 114..124
FT /evidence="ECO:0000256|PIRSR:PIRSR000666-3"
SQ SEQUENCE 1012 AA; 109481 MW; 9F63F230E338C9A2 CRC64;
MAAEGAARSG SGVAGMVCSL WVLGLASSVL ALEEVLLDTT GETSEIGWLT YPPGGWDEVS
VLDDQRRLTR TFEACHVAGA PPGTGQDNWL QTHFVERRGA QRAHIRLHFS VRACASLGVA
GGTCRETFTL YYRQAEEPDG PDSISSWHLK RWTKVDTIAA DESFPASSAW AVGPRGAGQR
AGLQLNVKER SFGPLTQRGF YVAFQDTGAC LALVAVKLFS YTCPSVLRAF ASFPETQASG
AGGASLVAAV GTCVAHAEPE EDGGGGQVGG SPPRLHCNGE GKWMVAVGGC RCQPGHQPAR
GDKACQACPE GSYKAMAGNA PCLPCPARSH APDPASPVCP CLEGFYRAGS DPPEAPCTGP
PSAPRELWFE VQGSVLMLHW RLPQELGGRG DLLFNVVCKE CGGHQEPGTG TPGTCRRCRD
EVHFDPRQRG LTESRVLVGG LRAHVPYILE VQAVNGVSEL SPDPPQAAAI NVSTSHAVPS
AVPALHQVSR ASNSITVSWP QPDQTNGNIL DYQLRYYDQA EDESHSFTLT SETNTATVTQ
LSPGHIYGFQ VRARTAAGHG PYGGKVYFQT LPQGELSTQL PERLSLVIGS ILGALAFLLL
AAITVLAVVF RRKRRGTGYT EQLQQYSSPG LGVKYYIDPS TYEDPCQAIR EFTREVDPAY
IKIEEVIGAG SFGEVRRGRL QPRGRREQAV AIQALWAGGT ESLQMTFLGQ AAVLGQFQHP
NILRLEGVVT KSRPLMVLTE LMELGPLDSF LRQREGQFSS LQLVAMQRGV AAAMQYLSSF
AFVHRALSAH SVLVNSHLVC KVARLGHSPQ GPSCMLRWAA PEVIAHGKHT TSSDIWSFGI
VMWEVMSYGE RPYWDMSDQE VLNAIEQEFR LPPPPGCPPG LHLLMLDTWQ KDRTQRPHFD
QLVAAFDKMI RKPDTLQADG GPGDRPSQAL LNPVALDFPS LDSPQAWLLA IGLECYQENF
SKFGLCTFSD VVQLGLEDLP ALGITLAGHQ KKLLHNIQLL QQHLTQPGSV EV
//
