ID A0A8C9EA51_PHOSS Unreviewed; 527 AA.
AC A0A8C9EA51;
DT 19-JAN-2022, integrated into UniProtKB/TrEMBL.
DT 19-JAN-2022, sequence version 1.
DT 28-JAN-2026, entry version 17.
DE SubName: Full=Chordin like 1 {ECO:0000313|Ensembl:ENSPSNP00000028996.1};
GN Name=CHRDL1 {ECO:0000313|Ensembl:ENSPSNP00000028996.1};
OS Phocoena sinus (Vaquita).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC Phocoenidae; Phocoena.
OX NCBI_TaxID=42100 {ECO:0000313|Ensembl:ENSPSNP00000028996.1, ECO:0000313|Proteomes:UP000694554};
RN [1] {ECO:0000313|Ensembl:ENSPSNP00000028996.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Morin P., Mountcastle J., Fungtammasan C., Rhie A., Rojas-Bracho L.,
RA Smith C.R., Taylor B.L., Gulland F.M.D., Musser W., Houck M., Haase B.,
RA Paez S., Howe K., Torrance J., Formenti G., Phillippy A., Ryder O.,
RA Jarvis E.D., Fedrigo O.;
RT "Phocoena sinus (Vaquita) genome, mPhoSin1, primary haplotype.";
RL Submitted (AUG-2019) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSPSNP00000028996.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (AUG-2025) to UniProtKB.
RN [3] {ECO:0000313|Ensembl:ENSPSNP00000028996.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2025) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
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DR RefSeq; XP_032476510.1; XM_032620619.1.
DR AlphaFoldDB; A0A8C9EA51; -.
DR Ensembl; ENSPSNT00000032550.1; ENSPSNP00000028996.1; ENSPSNG00000021005.1.
DR GeneID; 116747937; -.
DR KEGG; psiu:116747937; -.
DR CTD; 91851; -.
DR GeneTree; ENSGT00940000160983; -.
DR Proteomes; UP000694554; Chromosome X.
DR GO; GO:0005615; C:extracellular space; IEA:TreeGrafter.
DR GO; GO:0005886; C:plasma membrane; IEA:GOC.
DR GO; GO:0045202; C:synapse; IEA:GOC.
DR GO; GO:0036122; F:BMP binding; IEA:Ensembl.
DR GO; GO:0050431; F:transforming growth factor beta binding; IEA:Ensembl.
DR GO; GO:0097113; P:AMPA glutamate receptor clustering; IEA:Ensembl.
DR GO; GO:0030509; P:BMP signaling pathway; IEA:Ensembl.
DR GO; GO:0030154; P:cell differentiation; IEA:TreeGrafter.
DR GO; GO:0000578; P:embryonic axis specification; IEA:Ensembl.
DR GO; GO:0098976; P:excitatory chemical synaptic transmission; IEA:Ensembl.
DR GO; GO:0001654; P:eye development; IEA:Ensembl.
DR GO; GO:0030514; P:negative regulation of BMP signaling pathway; IEA:Ensembl.
DR GO; GO:0048167; P:regulation of synaptic plasticity; IEA:Ensembl.
DR GO; GO:0060074; P:synapse maturation; IEA:Ensembl.
DR FunFam; 2.10.70.10:FF:000005; Chordin-like 1, isoform CRA_c; 2.
DR Gene3D; 6.20.200.20; -; 1.
DR Gene3D; 2.10.70.10; Complement Module, domain 1; 2.
DR InterPro; IPR045717; CHRDL1/2.
DR InterPro; IPR045716; CHRDL_1/2_C.
DR InterPro; IPR001007; VWF_dom.
DR PANTHER; PTHR46303:SF2; CHORDIN-LIKE PROTEIN 1; 1.
DR PANTHER; PTHR46303; VWFC DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF19548; CHRDL_1_2_C; 1.
DR Pfam; PF00093; VWC; 1.
DR Pfam; PF23334; VWC2L_2nd; 2.
DR SMART; SM00214; VWC; 3.
DR SUPFAM; SSF57603; FnI-like domain; 3.
DR PROSITE; PS01208; VWFC_1; 3.
DR PROSITE; PS50184; VWFC_2; 3.
PE 4: Predicted;
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Reference proteome {ECO:0000313|Proteomes:UP000694554};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Signal {ECO:0000256|ARBA:ARBA00022729}.
FT DOMAIN 104..169
FT /note="VWFC"
FT /evidence="ECO:0000259|PROSITE:PS50184"
FT DOMAIN 183..249
FT /note="VWFC"
FT /evidence="ECO:0000259|PROSITE:PS50184"
FT DOMAIN 328..393
FT /note="VWFC"
FT /evidence="ECO:0000259|PROSITE:PS50184"
FT REGION 270..292
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 527 AA; 59727 MW; F987444187C4BE44 CRC64;
MFFLPPTFES PLPPRAHSSS RHNLRVLVLG GAPRGARSAC TRGRRRRPVA SLSTQGPESF
KLPFAVARIR KKWKMGGVRY IFSLLLFFLF LEGSKAEQVK HSETYCVFQD KKYRVGERWH
PYLEPYGLVY CVNCICSENG NVLCSRVRCP SLHCLSPVHI PHLCCPRCPE DSLPPANNKV
TSKSCEYNGT TYQHGELFMA EGLFQNRQPN QCTQCSCSEG NVYCGLKTCP KLTCAFPVSV
PDSCCRVCRG DGELSWEHSD GDIVRQPANR EARHSYHRSH YDPPASRQAG GLPRFPGARS
HRGALMDSQQ ASGTIVQIVI NNKHKHGQVC VSNGKTYSHG ESWHPNLRAF GIVECVLCTC
NVTKQECKKI HCPSRYPCKY PQKIDGKCCK VCPGKKAKEE LPGQSFDSKG YFCGEETMPV
YESVFMEDGE TTRKIALETE RPPQVEVHVW TIRKGILQHF HIEKISKRMF EELHHFKLVT
RTTLSQWKIF TEGEAQISQM CSSRVCRTEL EDLVKVLYLE RSEKGHC
//
