ID A0A8C9K1E4_PANTA Unreviewed; 332 AA.
AC A0A8C9K1E4;
DT 19-JAN-2022, integrated into UniProtKB/TrEMBL.
DT 19-JAN-2022, sequence version 1.
DT 28-JAN-2026, entry version 21.
DE RecName: Full=Nuclear migration protein nudC {ECO:0000256|ARBA:ARBA00017641};
DE AltName: Full=Nuclear distribution protein C homolog {ECO:0000256|ARBA:ARBA00030427};
GN Name=NUDC {ECO:0000313|Ensembl:ENSPTIP00000015643.1};
OS Panthera tigris altaica (Siberian tiger).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Pantherinae;
OC Panthera.
OX NCBI_TaxID=74533 {ECO:0000313|Ensembl:ENSPTIP00000015643.1, ECO:0000313|Proteomes:UP000675900};
RN [1] {ECO:0000313|Ensembl:ENSPTIP00000015643.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (AUG-2025) to UniProtKB.
RN [2] {ECO:0000313|Ensembl:ENSPTIP00000015643.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2025) to UniProtKB.
CC -!- FUNCTION: Plays a role in neurogenesis and neuronal migration.
CC Necessary for correct formation of mitotic spindles and chromosome
CC separation during mitosis. Necessary for cytokinesis and cell
CC proliferation. {ECO:0000256|ARBA:ARBA00046142}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, spindle
CC {ECO:0000256|ARBA:ARBA00004186}. Midbody
CC {ECO:0000256|ARBA:ARBA00004214}.
CC -!- SIMILARITY: Belongs to the nudC family.
CC {ECO:0000256|ARBA:ARBA00010513}.
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DR RefSeq; XP_007078200.1; XM_007078138.2.
DR AlphaFoldDB; A0A8C9K1E4; -.
DR Ensembl; ENSPTIT00000019790.1; ENSPTIP00000015643.1; ENSPTIG00000014669.1.
DR GeneID; 102957367; -.
DR KEGG; ptg:102957367; -.
DR CTD; 10726; -.
DR GeneTree; ENSGT00940000155361; -.
DR Proteomes; UP000675900; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:TreeGrafter.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0030496; C:midbody; IEA:UniProtKB-SubCell.
DR GO; GO:0005819; C:spindle; IEA:UniProtKB-SubCell.
DR GO; GO:0051082; F:unfolded protein binding; IEA:TreeGrafter.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR GO; GO:0051656; P:establishment of organelle localization; IEA:UniProtKB-ARBA.
DR GO; GO:0006457; P:protein folding; IEA:TreeGrafter.
DR CDD; cd06492; p23_mNUDC_like; 1.
DR FunFam; 2.60.40.790:FF:000001; Nuclear migration protein nudC; 1.
DR Gene3D; 2.60.40.790; -; 1.
DR InterPro; IPR007052; CS_dom.
DR InterPro; IPR008978; HSP20-like_chaperone.
DR InterPro; IPR032572; NuDC.
DR InterPro; IPR037898; NudC_fam.
DR InterPro; IPR025934; NudC_N_dom.
DR PANTHER; PTHR12356:SF3; NUCLEAR MIGRATION PROTEIN NUDC; 1.
DR PANTHER; PTHR12356; NUCLEAR MOVEMENT PROTEIN NUDC; 1.
DR Pfam; PF04969; CS; 1.
DR Pfam; PF16273; NuDC; 1.
DR Pfam; PF14050; Nudc_N; 1.
DR SUPFAM; SSF49764; HSP20-like chaperones; 1.
DR PROSITE; PS51203; CS; 1.
PE 3: Inferred from homology;
KW Cell cycle {ECO:0000256|ARBA:ARBA00023306};
KW Cell division {ECO:0000256|ARBA:ARBA00022618};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Mitosis {ECO:0000256|ARBA:ARBA00022776};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000675900}.
FT DOMAIN 168..259
FT /note="CS"
FT /evidence="ECO:0000259|PROSITE:PS51203"
FT REGION 66..108
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 127..170
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 75..97
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 145..154
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 332 AA; 38365 MW; ED0933E7379AFFD6 CRC64;
MGGEQEEERF DGMLLAMAQQ HEGGVQELVN TFFSFLRRKT DFFVGGEEGM AEKLITQTFN
HHNQLAQKAR REKRSRQENE RREKAERAAR LAKEAKSETS GPQIKELTDE EAERLQLEID
QKKDAENHEA QLKNGSVGSP GKQEAEEDEE EEDEKDKGKL KPNLGNGADL PNYRWTQTLS
ELDLALPFHV NFRLKGKDVV VDIHRRHLRV GLKGQPAIID GELYNEVKVE ESSWLIEDGK
VVTVHLEKIN KMEWWSRLVS TDPEINTKKI NPENSKLSDL DSETRSMVEK MMYDQRQKSM
GLPTSDEQKK QEILKKFMDQ HPEMDFSKAK FN
//
