ID A0A8C9LB40_PAVCR Unreviewed; 215 AA.
AC A0A8C9LB40;
DT 19-JAN-2022, integrated into UniProtKB/TrEMBL.
DT 19-JAN-2022, sequence version 1.
DT 28-JAN-2026, entry version 21.
DE RecName: Full=Hairy and enhancer of split-related protein HELT {ECO:0000256|ARBA:ARBA00073323};
DE AltName: Full=HES/HEY-like transcription factor {ECO:0000256|ARBA:ARBA00078769};
OS Pavo cristatus (Indian peafowl) (Blue peafowl).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Pavo.
OX NCBI_TaxID=9049 {ECO:0000313|Ensembl:ENSPSTP00000014229.1, ECO:0000313|Proteomes:UP000694428};
RN [1] {ECO:0000313|Ensembl:ENSPSTP00000014229.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (AUG-2025) to UniProtKB.
RN [2] {ECO:0000313|Ensembl:ENSPSTP00000014229.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2025) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the HEY family. {ECO:0000256|ARBA:ARBA00038262}.
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DR AlphaFoldDB; A0A8C9LB40; -.
DR Ensembl; ENSPSTT00000014935.1; ENSPSTP00000014229.1; ENSPSTG00000010068.1.
DR Proteomes; UP000694428; Unplaced.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR FunFam; 4.10.280.10:FF:000054; hairy and enhancer of split-related protein HELT; 1.
DR Gene3D; 6.10.250.980; -; 1.
DR Gene3D; 4.10.280.10; Helix-loop-helix DNA-binding domain; 1.
DR InterPro; IPR011598; bHLH_dom.
DR InterPro; IPR050370; HES_HEY.
DR InterPro; IPR036638; HLH_DNA-bd_sf.
DR InterPro; IPR003650; Orange_dom.
DR PANTHER; PTHR10985; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTOR, HES-RELATED; 1.
DR Pfam; PF07527; Hairy_orange; 1.
DR Pfam; PF00010; HLH; 1.
DR SMART; SM00353; HLH; 1.
DR SUPFAM; SSF47459; HLH, helix-loop-helix DNA-binding domain; 1.
DR SUPFAM; SSF158457; Orange domain-like; 1.
DR PROSITE; PS50888; BHLH; 1.
DR PROSITE; PS51054; ORANGE; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000694428};
KW Repressor {ECO:0000256|ARBA:ARBA00022491};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 10..65
FT /note="BHLH"
FT /evidence="ECO:0000259|PROSITE:PS50888"
FT DOMAIN 86..121
FT /note="Orange"
FT /evidence="ECO:0000259|PROSITE:PS51054"
FT REGION 135..160
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 191..215
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 215 AA; 23798 MW; EFDAC271140C8E28 CRC64;
MASGLKERRR TPVSHKVIEK RRRDRINRCL AELGRTVPLA LAKQGSGKLE KAEILEMTVQ
YLRALHSADF PRGREKELLS EFANYFHYGY HECMKNLVHY LTTVERMETK DTKYARILAF
LQSKARFAAE PLLAAPPEPD AAFPPPPERP PGPAEPFPWP YGPLPAPAAL GGPGQQRAAF
LPSAQGLERR YLGLLGPPPP GAFGLPPGQH PPAVL
//
