ID A0A8C9NII8_SERCA Unreviewed; 419 AA.
AC A0A8C9NII8;
DT 19-JAN-2022, integrated into UniProtKB/TrEMBL.
DT 19-JAN-2022, sequence version 1.
DT 28-JAN-2026, entry version 19.
DE SubName: Full=Chordin like 2 {ECO:0000313|Ensembl:ENSSCAP00000018549.1};
GN Name=CHRDL2 {ECO:0000313|Ensembl:ENSSCAP00000018549.1};
OS Serinus canaria (Island canary) (Fringilla canaria).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Neoaves; Telluraves; Australaves;
OC Passeriformes; Passeroidea; Fringillidae; Carduelinae; Serinus.
OX NCBI_TaxID=9135 {ECO:0000313|Ensembl:ENSSCAP00000018549.1, ECO:0000313|Proteomes:UP000694409};
RN [1] {ECO:0000313|Ensembl:ENSSCAP00000018549.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (AUG-2025) to UniProtKB.
RN [2] {ECO:0000313|Ensembl:ENSSCAP00000018549.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2025) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
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DR AlphaFoldDB; A0A8C9NII8; -.
DR Ensembl; ENSSCAT00000020740.1; ENSSCAP00000018549.1; ENSSCAG00000013428.1.
DR GeneTree; ENSGT00940000161241; -.
DR OMA; HGKRYAP; -.
DR Proteomes; UP000694409; Unassembled WGS sequence.
DR GO; GO:0005615; C:extracellular space; IEA:TreeGrafter.
DR GO; GO:0036122; F:BMP binding; IEA:TreeGrafter.
DR GO; GO:0030154; P:cell differentiation; IEA:TreeGrafter.
DR GO; GO:0030514; P:negative regulation of BMP signaling pathway; IEA:TreeGrafter.
DR GO; GO:0048731; P:system development; IEA:UniProtKB-ARBA.
DR FunFam; 2.10.70.10:FF:000005; Chordin-like 1, isoform CRA_c; 1.
DR Gene3D; 2.10.70.10; Complement Module, domain 1; 2.
DR InterPro; IPR045717; CHRDL1/2.
DR InterPro; IPR045716; CHRDL_1/2_C.
DR InterPro; IPR001007; VWF_dom.
DR PANTHER; PTHR46303:SF3; CHORDIN-LIKE PROTEIN 2; 1.
DR PANTHER; PTHR46303; VWFC DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF19548; CHRDL_1_2_C; 1.
DR Pfam; PF00093; VWC; 1.
DR Pfam; PF23334; VWC2L_2nd; 1.
DR SMART; SM00214; VWC; 2.
DR SUPFAM; SSF57603; FnI-like domain; 3.
DR PROSITE; PS01208; VWFC_1; 1.
DR PROSITE; PS50184; VWFC_2; 2.
PE 4: Predicted;
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Reference proteome {ECO:0000313|Proteomes:UP000694409};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Signal {ECO:0000256|ARBA:ARBA00022729}.
FT DOMAIN 98..164
FT /note="VWFC"
FT /evidence="ECO:0000259|PROSITE:PS50184"
FT DOMAIN 239..304
FT /note="VWFC"
FT /evidence="ECO:0000259|PROSITE:PS50184"
SQ SEQUENCE 419 AA; 46420 MW; DF4385FA56855AEF CRC64;
NHPQTGVCSE RAGPLFSPGL SRLLAGPEAF CDFNGKKYSP GESWHPYLEP QGLMYCIRCS
CAEASPARPP PGPVTEPQQC CPRCPEPPSP SGLRAPARSC RYNGTTFQQG EMFSGSELFP
GRQPNQCVQC SCSEGQIYCG LVTCPELLCS SPFSVPDSCC QVCKDGSLEK PTEEEPLQLN
RGVRHSQDQC LGEVVGRKPP GATVSTVLSS SLELIPRSFK PKGAGGTTVK IVLKEKHKKA
CVYNGKTYSH GDVWHPVFRL YGLLPCILCT CRDGVQDCHK VTCPKEYPCE HPEKVDGKCC
KVCPGRWDPE VATPRCGSGP SRVLVYAFVP PRSEPSKEIL RTVAIEKELA EEVEIYNWKL
IKGIFHLIQT KKISKQEFKQ EAQHFRLITR TNEGHWNIFR AQTSELRMTE SPEKETKTS
//
