ID A0A8C9NJ05_SERCA Unreviewed; 438 AA.
AC A0A8C9NJ05;
DT 19-JAN-2022, integrated into UniProtKB/TrEMBL.
DT 19-JAN-2022, sequence version 1.
DT 10-JUN-2026, entry version 20.
DE SubName: Full=Synapse defective Rho GTPase homolog 2 {ECO:0000313|Ensembl:ENSSCAP00000019579.1};
GN Name=SYDE2 {ECO:0000313|Ensembl:ENSSCAP00000019579.1};
OS Serinus canaria (Island canary) (Fringilla canaria).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Neoaves; Telluraves; Australaves;
OC Passeriformes; Passeroidea; Fringillidae; Carduelinae; Serinus.
OX NCBI_TaxID=9135 {ECO:0000313|Ensembl:ENSSCAP00000019579.1, ECO:0000313|Proteomes:UP000694409};
RN [1] {ECO:0000313|Ensembl:ENSSCAP00000019579.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (JAN-2026) to UniProtKB.
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DR AlphaFoldDB; A0A8C9NJ05; -.
DR Ensembl; ENSSCAT00000021868.1; ENSSCAP00000019579.1; ENSSCAG00000014128.1.
DR GeneTree; ENSGT01030000234635; -.
DR OMA; QLWPEPA; -.
DR Proteomes; UP000694409; Unassembled WGS sequence.
DR GO; GO:0097060; C:synaptic membrane; IEA:TreeGrafter.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR GO; GO:0016477; P:cell migration; IEA:TreeGrafter.
DR GO; GO:0046578; P:regulation of Ras protein signal transduction; IEA:TreeGrafter.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR FunFam; 1.10.555.10:FF:000031; rho GTPase-activating protein 100F isoform X6; 1.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR InterPro; IPR052118; Rho-GAP_regulator.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR InterPro; IPR057459; SYDE1/2_C2.
DR PANTHER; PTHR46150; RHO GTPASE-ACTIVATING PROTEIN 100F; 1.
DR PANTHER; PTHR46150:SF1; RHO GTPASE-ACTIVATING PROTEIN SYDE2; 1.
DR Pfam; PF25336; C2_SYDE; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR PROSITE; PS50238; RHOGAP; 1.
PE 4: Predicted;
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468, ECO:0000256|PROSITE-
KW ProRule:PRU00172}; Reference proteome {ECO:0000313|Proteomes:UP000694409}.
FT DOMAIN 66..281
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT REGION 310..331
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 354..393
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 354..368
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 438 AA; 48725 MW; 6B53A022B814E0F0 CRC64;
STEVSPPMCC HGTVALPTLF RVTKTHQLAV KLEPRGLIYV KLSLMEQWEN SLDGLDTNRE
PVMFGVDARK VVEKENAGLM VPLLLQKCIL EIEKRGCQVV GLYRLCGSAA VKKELREAFE
RDSKAVTLCE SQYPDINVIT GVLKDYLREL PSPLITKQLY EAVLDAMVKN PLKMTASGCE
NDPSDSEHTA ALLDCLPDVE KATLKMLLDH LKLVASYHEV NKMTCQNLAV CFGPVLLSQR
QETTNHNNRV FTDSEELASA LDFKKHIEVL HYLLQLWPEP AHVTAFPEHS SCLNYLRPKR
QRPQVLNLSG TEMSGVLRPR PAGLDSPSSN RYAGDWSSCG ENYLLAPRDC LGEADYDDVP
SEGTESGEDS SRAEELDDPA GRPQPSPAEY SFGSCLTVPA MDSAVDHRAH LKDLQESIDT
LIGNLERELN KNKLNMSY
//
