ID A0A8C9UMT6_SPEDA Unreviewed; 829 AA.
AC A0A8C9UMT6;
DT 19-JAN-2022, integrated into UniProtKB/TrEMBL.
DT 19-JAN-2022, sequence version 1.
DT 10-JUN-2026, entry version 21.
DE RecName: Full=Outer dense fiber protein 2 {ECO:0000256|ARBA:ARBA00040458};
DE AltName: Full=Cenexin {ECO:0000256|ARBA:ARBA00041830};
DE AltName: Full=Outer dense fiber of sperm tails protein 2 {ECO:0000256|ARBA:ARBA00043200};
OS Spermophilus dauricus (Daurian ground squirrel).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Sciuromorpha; Sciuridae;
OC Xerinae; Marmotini; Spermophilus.
OX NCBI_TaxID=99837 {ECO:0000313|Ensembl:ENSSDAP00000009181.1, ECO:0000313|Proteomes:UP000694422};
RN [1] {ECO:0000313|Ensembl:ENSSDAP00000009181.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (JAN-2026) to UniProtKB.
CC -!- FUNCTION: Seems to be a major component of sperm tail outer dense
CC fibers (ODF). ODFs are filamentous structures located on the outside of
CC the axoneme in the midpiece and principal piece of the mammalian sperm
CC tail and may help to maintain the passive elastic structures and
CC elastic recoil of the sperm tail. May have a modulating influence on
CC sperm motility. Functions as a general scaffold protein that is
CC specifically localized at the distal/subdistal appendages of mother
CC centrioles. Component of the centrosome matrix required for the
CC localization of PLK1 and NIN to the centrosomes. Required for the
CC formation and/or maintenance of normal CETN1 assembly.
CC {ECO:0000256|ARBA:ARBA00037601}.
CC -!- SUBCELLULAR LOCATION: Cell projection, cilium, flagellum
CC {ECO:0000256|ARBA:ARBA00004230}. Cytoplasm, cytoskeleton, microtubule
CC organizing center, centrosome, centriole
CC {ECO:0000256|ARBA:ARBA00004114}. Cytoplasm, cytoskeleton, spindle pole
CC {ECO:0000256|ARBA:ARBA00004647}.
CC -!- SIMILARITY: Belongs to the ODF2 family.
CC {ECO:0000256|ARBA:ARBA00009316}.
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DR AlphaFoldDB; A0A8C9UMT6; -.
DR Ensembl; ENSSDAT00000010429.1; ENSSDAP00000009181.1; ENSSDAG00000008258.1.
DR Proteomes; UP000694422; Unplaced.
DR GO; GO:0005814; C:centriole; IEA:UniProtKB-SubCell.
DR GO; GO:0005813; C:centrosome; IEA:TreeGrafter.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0031514; C:motile cilium; IEA:UniProtKB-SubCell.
DR GO; GO:0000922; C:spindle pole; IEA:UniProtKB-SubCell.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR GO; GO:1902017; P:regulation of cilium assembly; IEA:TreeGrafter.
DR GO; GO:0007283; P:spermatogenesis; IEA:UniProtKB-KW.
DR InterPro; IPR026099; ODF2/BCAP.
DR PANTHER; PTHR23162; OUTER DENSE FIBER OF SPERM TAILS 2; 1.
DR PANTHER; PTHR23162:SF8; OUTER DENSE FIBER PROTEIN 2; 1.
DR Pfam; PF27605; ODF2_C; 1.
DR Pfam; PF27578; ODF2_N; 1.
PE 3: Inferred from homology;
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Cilium {ECO:0000256|ARBA:ARBA00023069};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW Differentiation {ECO:0000256|ARBA:ARBA00022782};
KW Flagellum {ECO:0000256|ARBA:ARBA00022846};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Reference proteome {ECO:0000313|Proteomes:UP000694422};
KW Spermatogenesis {ECO:0000256|ARBA:ARBA00022871}.
FT REGION 810..829
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 152..217
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 297..419
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 522..796
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 819..829
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 829 AA; 95505 MW; A2A97CCCC0273FE1 CRC64;
MSASSSGGSP RFPSCGKNGV TSLTQKKVLR TPCGAPSVTV TKSHKRGMKG DTVNVRRSVR
VKTKVPWMPP GKSSARHVGC KWETPPHCLE ITPPSSEKLV SVMRLSDLST EDDDSGHCKM
NHYDKKIDSL MNAVGCLKSE VKMQKGERQM AKRFLEERKE ELEEVAHELA ETEHENTVLR
HNIERIKEEK DFTMLQKKHL QQEKECLMSK LVEAEMDGAA AAKQVMALKD TIGKLKTEKQ
MTCTDINTLT RQKELLLQKL STFEETNRTL RDLLREQHCK EDSERLMEQQ GALLKRLAEA
DSEKARLLLM LQDKDKEVEE LLQEIQCEKA QAKTASELSK SMESMRGHLQ AQLRCKEAEN
SRLCMQIKNL ERSGNQHKAE VEAIMEQLKE LKQKGDRDKD TLKKAIRAQK ERAEKSEEYA
EQLHVQLADK DLYVAEALST LESWRSRYNQ VVKDKGDLEL EIIVLNDRVT DLVNQQQTLE
EKMREDRDSL VERLHRQTAE YSAFKLENER LKASFAPMED KLNQAHIEVQ QLKASVKNYE
GMIDNYKSQV MKTRLEADEV AAQLERCDKE NKILKDEMNK EIEAARRQFQ SQLADLQQLP
DILKITEAKL AECQDQLQGY ERKNIDLTAI ISDLRSRIEH QGDKLEMARE KHQASQKENK
QLSLKVDELE RKLEATNAQN VEFLQVIAKR EEAIHQSQLR LEEKTRECGS LARQLESALE
DARRQVEQTK EQALSKERAA QNKILDLETQ LSRTKTELSQ LRRTRDDADR RYQSRLQDLK
DRLEQSESTN RSMQNYVQFL KSSYANVFGD GPYTSYLTSS PIRSRSPPP
//
