ID   A0A8C9UQ79_SPEDA        Unreviewed;       650 AA.
AC   A0A8C9UQ79;
DT   19-JAN-2022, integrated into UniProtKB/TrEMBL.
DT   19-JAN-2022, sequence version 1.
DT   10-JUN-2026, entry version 21.
DE   RecName: Full=Kalirin {ECO:0008006|Google:ProtNLM};
OS   Spermophilus dauricus (Daurian ground squirrel).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Sciuromorpha; Sciuridae;
OC   Xerinae; Marmotini; Spermophilus.
OX   NCBI_TaxID=99837 {ECO:0000313|Ensembl:ENSSDAP00000014305.1, ECO:0000313|Proteomes:UP000694422};
RN   [1] {ECO:0000313|Ensembl:ENSSDAP00000014305.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JAN-2026) to UniProtKB.
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DR   AlphaFoldDB; A0A8C9UQ79; -.
DR   Ensembl; ENSSDAT00000016207.1; ENSSDAP00000014305.1; ENSSDAG00000012544.1.
DR   Proteomes; UP000694422; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IEA:TreeGrafter.
DR   GO; GO:0019898; C:extrinsic component of membrane; IEA:TreeGrafter.
DR   GO; GO:0014069; C:postsynaptic density; IEA:TreeGrafter.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR   GO; GO:0007411; P:axon guidance; IEA:TreeGrafter.
DR   GO; GO:0035556; P:intracellular signal transduction; IEA:TreeGrafter.
DR   CDD; cd13241; PH2_Kalirin_Trio_p63RhoGEF; 1.
DR   CDD; cd00160; RhoGEF; 1.
DR   CDD; cd11853; SH3_Kalirin_2; 1.
DR   FunFam; 2.30.29.30:FF:000091; kalirin isoform X1; 1.
DR   FunFam; 2.30.30.40:FF:000038; kalirin isoform X1; 1.
DR   Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR   Gene3D; 2.30.30.40; SH3 Domains; 1.
DR   InterPro; IPR035899; DBL_dom_sf.
DR   InterPro; IPR000219; DH_dom.
DR   InterPro; IPR047053; Kalirin_TRIO_SH3_2.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR001849; PH_domain.
DR   InterPro; IPR051336; RhoGEF_Guanine_NuclExch_SF.
DR   InterPro; IPR036028; SH3-like_dom_sf.
DR   InterPro; IPR001452; SH3_domain.
DR   InterPro; IPR055251; SOS1_NGEF_PH.
DR   PANTHER; PTHR22826:SF49; KALIRIN; 1.
DR   PANTHER; PTHR22826; RHO GUANINE EXCHANGE FACTOR-RELATED; 1.
DR   Pfam; PF00621; RhoGEF; 1.
DR   Pfam; PF16609; SH3-RhoG_link; 1.
DR   Pfam; PF23587; SH3_KALRN; 1.
DR   Pfam; PF22697; SOS1_NGEF_PH; 1.
DR   SMART; SM00233; PH; 1.
DR   SMART; SM00325; RhoGEF; 1.
DR   SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR   SUPFAM; SSF50729; PH domain-like; 1.
DR   SUPFAM; SSF50044; SH3-domain; 1.
DR   PROSITE; PS50010; DH_2; 1.
DR   PROSITE; PS50003; PH_DOMAIN; 1.
DR   PROSITE; PS50002; SH3; 1.
PE   4: Predicted;
KW   Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW   Reference proteome {ECO:0000313|Proteomes:UP000694422};
KW   SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW   ProRule:PRU00192}.
FT   DOMAIN          200..351
FT                   /note="DH"
FT                   /evidence="ECO:0000259|PROSITE:PS50010"
FT   DOMAIN          363..473
FT                   /note="PH"
FT                   /evidence="ECO:0000259|PROSITE:PS50003"
FT   DOMAIN          568..633
FT                   /note="SH3"
FT                   /evidence="ECO:0000259|PROSITE:PS50002"
FT   REGION          35..188
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          491..544
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        35..70
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        121..130
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   650 AA;  72944 MW;  137C696447C7831E CRC64;
     MKGGDRAYTR GPSLGWLFSK CCCCFPCGDA YSHSSSENGG KSESVANLQA QPSLNSIHSS
     PGPKRSTNTL KKWLTSPVRR LNSGKADGNI KKQKKVRDGR KSFDLGSPKP GDETTPQGDS
     ADEKSKKGWG EDEPDEESHT PLPPPMKIFD NDPTQDEMTL EGGSYRGSLK DPTGCLNEGM
     TPPTPPRNLE EEQKAKALRG RMFVLNELVQ TEKDYVKDLG IVVEGFMKRI EEKGVPEDMR
     GKDKIVFGNI HQIYDWHKER KLHIYVWYCQ NKPRSEYIVA EYDAYFEEVK QELNQRLTLS
     DFLIKPIQRI TKYQLLLKDF LRYSEKAGLE CSDIEKAVEL MCLVPKRCND MMNLGRLQGF
     EGTLTAQGKL LQQDTFYVIE LDAGMQSRTK ERRVFLFEQI VIFSELLRKG SLTPGYMFKK
     SIKMNYLVLE ENVDNDPCKF ALMNRETSER VILQAANSDI QQAWVQDINQ VLETQRDFLN
     ALQSPIEYQR KERSTAVMRS QPARVPQASP RPYSSVPMGS EKPPKGSTYN PPLPPLKIST
     SNGSPGFDYH QSGDKFEASK QNDLGGCNGT SSMAVIKDYY ALKENEICVS QGEVVQVLAV
     NQQNMCLVYQ PASDHSPAAE GWVPGSILAP LTKATAAAEN SDGSIKQEPY
//