ID A0A8D0A3R8_SANLU Unreviewed; 780 AA.
AC A0A8D0A3R8;
DT 19-JAN-2022, integrated into UniProtKB/TrEMBL.
DT 19-JAN-2022, sequence version 1.
DT 28-JAN-2026, entry version 19.
DE RecName: Full=Integrin beta {ECO:0000256|RuleBase:RU000633};
GN Name=itgb5 {ECO:0000313|Ensembl:ENSSLUP00000050141.1};
OS Sander lucioperca (Pike-perch) (Perca lucioperca).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Perciformes; Percoidei; Percidae; Luciopercinae; Sander.
OX NCBI_TaxID=283035 {ECO:0000313|Ensembl:ENSSLUP00000050141.1, ECO:0000313|Proteomes:UP000694568};
RN [1] {ECO:0000313|Ensembl:ENSSLUP00000050141.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (AUG-2025) to UniProtKB.
RN [2] {ECO:0000313|Ensembl:ENSSLUP00000050141.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2025) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004251,
CC ECO:0000256|RuleBase:RU000633}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004251, ECO:0000256|RuleBase:RU000633}.
CC -!- SIMILARITY: Belongs to the integrin beta chain family.
CC {ECO:0000256|ARBA:ARBA00007449, ECO:0000256|RuleBase:RU000633}.
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DR AlphaFoldDB; A0A8D0A3R8; -.
DR Ensembl; ENSSLUT00000051631.1; ENSSLUP00000050141.1; ENSSLUG00000020388.1.
DR GeneTree; ENSGT01150000286919; -.
DR Proteomes; UP000694568; Unplaced.
DR GO; GO:0009986; C:cell surface; IEA:TreeGrafter.
DR GO; GO:0005925; C:focal adhesion; IEA:TreeGrafter.
DR GO; GO:0008305; C:integrin complex; IEA:TreeGrafter.
DR GO; GO:0005178; F:integrin binding; IEA:TreeGrafter.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0033627; P:cell adhesion mediated by integrin; IEA:TreeGrafter.
DR GO; GO:0016477; P:cell migration; IEA:TreeGrafter.
DR GO; GO:0098609; P:cell-cell adhesion; IEA:TreeGrafter.
DR GO; GO:0007160; P:cell-matrix adhesion; IEA:TreeGrafter.
DR GO; GO:0007229; P:integrin-mediated signaling pathway; IEA:UniProtKB-KW.
DR GO; GO:0043149; P:stress fiber assembly; IEA:TreeGrafter.
DR GO; GO:0007179; P:transforming growth factor beta receptor signaling pathway; IEA:TreeGrafter.
DR FunFam; 2.10.25.10:FF:000043; Integrin beta; 1.
DR FunFam; 2.10.25.10:FF:000075; Integrin beta; 1.
DR FunFam; 2.10.25.10:FF:000258; Integrin beta; 1.
DR FunFam; 3.30.1680.10:FF:000002; Integrin beta; 1.
DR FunFam; 3.40.50.410:FF:000002; Integrin beta; 1.
DR FunFam; 4.10.1240.30:FF:000001; Integrin beta; 1.
DR Gene3D; 4.10.1240.30; -; 1.
DR Gene3D; 1.20.5.100; Cytochrome c1, transmembrane anchor, C-terminal; 1.
DR Gene3D; 2.10.25.10; Laminin; 4.
DR Gene3D; 3.30.1680.10; ligand-binding face of the semaphorins, domain 2; 1.
DR Gene3D; 2.60.40.1510; ntegrin, alpha v. Chain A, domain 3; 1.
DR Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR InterPro; IPR013111; EGF_extracell.
DR InterPro; IPR040622; EGF_integrin_1.
DR InterPro; IPR057073; EGF_integrin_2.
DR InterPro; IPR033760; Integrin_beta_N.
DR InterPro; IPR015812; Integrin_bsu.
DR InterPro; IPR014836; Integrin_bsu_cyt_dom.
DR InterPro; IPR012896; Integrin_bsu_tail.
DR InterPro; IPR036349; Integrin_bsu_tail_dom_sf.
DR InterPro; IPR002369; Integrin_bsu_VWA.
DR InterPro; IPR032695; Integrin_dom_sf.
DR InterPro; IPR057243; Integrin_I-EGF_CS.
DR InterPro; IPR016201; PSI.
DR InterPro; IPR036465; vWFA_dom_sf.
DR PANTHER; PTHR10082; INTEGRIN BETA SUBUNIT; 1.
DR PANTHER; PTHR10082:SF26; INTEGRIN BETA-5; 1.
DR Pfam; PF07974; EGF_2; 1.
DR Pfam; PF23105; EGF_integrin; 1.
DR Pfam; PF18372; I-EGF_1; 1.
DR Pfam; PF08725; Integrin_b_cyt; 1.
DR Pfam; PF07965; Integrin_B_tail; 1.
DR Pfam; PF00362; Integrin_beta; 1.
DR Pfam; PF17205; PSI_integrin; 1.
DR PIRSF; PIRSF002512; Integrin_B; 1.
DR PRINTS; PR01186; INTEGRINB.
DR SMART; SM00187; INB; 1.
DR SMART; SM01241; Integrin_b_cyt; 1.
DR SMART; SM01242; Integrin_B_tail; 1.
DR SMART; SM00423; PSI; 1.
DR SUPFAM; SSF57196; EGF/Laminin; 2.
DR SUPFAM; SSF69687; Integrin beta tail domain; 1.
DR SUPFAM; SSF69179; Integrin domains; 2.
DR SUPFAM; SSF103575; Plexin repeat; 1.
DR SUPFAM; SSF53300; vWA-like; 1.
DR PROSITE; PS00243; I_EGF_1; 1.
DR PROSITE; PS52047; I_EGF_2; 3.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889,
KW ECO:0000256|RuleBase:RU000633};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157,
KW ECO:0000256|PIRSR:PIRSR002512-1};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Integrin {ECO:0000256|ARBA:ARBA00023037, ECO:0000256|RuleBase:RU000633};
KW Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000694568};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU000633};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 702..728
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 12..61
FT /note="PSI"
FT /evidence="ECO:0000259|SMART:SM00423"
FT DOMAIN 20..445
FT /note="Integrin beta subunit VWA"
FT /evidence="ECO:0000259|SMART:SM00187"
FT DOMAIN 617..701
FT /note="Integrin beta subunit tail"
FT /evidence="ECO:0000259|SMART:SM01242"
FT DOMAIN 725..769
FT /note="Integrin beta subunit cytoplasmic"
FT /evidence="ECO:0000259|SMART:SM01241"
FT DISULFID 21..31
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 24..60
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 34..49
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 188..197
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 245..286
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 383..395
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 415..664
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 443..447
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 466..504
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 471..480
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 482..495
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 510..515
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 512..545
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 517..530
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 532..537
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 551..556
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 553..584
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 558..567
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 590..595
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 592..640
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 597..607
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 610..613
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 617..626
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 623..696
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 644..672
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
SQ SEQUENCE 780 AA; 85590 MW; C258A0C186242916 CRC64;
MISSHPFSGL NMCMSGSATS CEECLLIHPS CAWCAQEEFG RGRTLTSRCD LSQNLQKRGC
EARFIEYPTS SISVLQNMPL SSKGSGLTQY GVVQIMPQKI SLSLRPGDQT WFGLQVRQVE
DYPVDLYYLM DLSLSMKDDL DTIRNLGTKL ALEMSKLTSN FRLGFGSFVD KNMSPFSYTA
SKYQENPCNG YKLFPNCVPT FGFRHILSLT DKVDRFNEEV QKQMVSRNRD APEGGFDAIL
QAAVCKEEIG WRKEAYHLLV FATDDVPHLA LDGRLGGLVQ PHDGQCHLND ENEYSASEKM
VRRAALSVVL LTNRAVSLTL SLISSLPKDF TALIPGTTVE ILDQDSKNVI QLIIAAYNNI
RSKVELSVWD HPEDINLSFT ATCQDGKPLP GLRKCADLKI GDTVSFNVSV EARSCPPRGT
DQSFTIKPVG FKERLEVSVD YQCDCGCSRT AQTNSSICSS IGTYNCGTCH CEPGYLGARC
ECQEGEASSM YLSACREAEG KQVCSGRGEC SCNQCLCYES EFGKIYGSYC ECDDFSCARH
KGVLCSGHGE CHCGECKCHA GYIGDNCNCS TETSSCIADD GQMCSGRGNC VCGRCQCTEP
GAFGDTCEKC PTCPDACGTK RECIECRLFN SGQLADNQTC QRLCKDEIIT VETLKTEEPG
AVLCLYKTDN DCVMKFTYSE HASGQSVLTA LKEPECGGGP DALMVLLAVV GSILLVGVVL
LAVWKLVITI HDRREFSRFQ SARSRARYEM VRSIPLFVFG NKTSSFSRLF CRGTAALCAA
//
