ID A0A8D0AS45_SANLU Unreviewed; 363 AA.
AC A0A8D0AS45;
DT 19-JAN-2022, integrated into UniProtKB/TrEMBL.
DT 19-JAN-2022, sequence version 1.
DT 28-JAN-2026, entry version 19.
DE SubName: Full=Suppressor of cytokine signaling 9 {ECO:0000313|Ensembl:ENSSLUP00000059011.1};
OS Sander lucioperca (Pike-perch) (Perca lucioperca).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Perciformes; Percoidei; Percidae; Luciopercinae; Sander.
OX NCBI_TaxID=283035 {ECO:0000313|Ensembl:ENSSLUP00000059011.1, ECO:0000313|Proteomes:UP000694568};
RN [1] {ECO:0000313|Ensembl:ENSSLUP00000059011.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (AUG-2025) to UniProtKB.
RN [2] {ECO:0000313|Ensembl:ENSSLUP00000059011.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2025) to UniProtKB.
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC {ECO:0000256|ARBA:ARBA00004906}.
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DR AlphaFoldDB; A0A8D0AS45; -.
DR Ensembl; ENSSLUT00000060698.1; ENSSLUP00000059011.1; ENSSLUG00000025271.1.
DR GeneTree; ENSGT00940000164285; -.
DR UniPathway; UPA00143; -.
DR Proteomes; UP000694568; Unplaced.
DR GO; GO:0005942; C:phosphatidylinositol 3-kinase complex; IEA:TreeGrafter.
DR GO; GO:0046935; F:1-phosphatidylinositol-3-kinase regulator activity; IEA:TreeGrafter.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR GO; GO:0009968; P:negative regulation of signal transduction; IEA:UniProtKB-KW.
DR GO; GO:0046854; P:phosphatidylinositol phosphate biosynthetic process; IEA:TreeGrafter.
DR GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR FunFam; 3.30.505.10:FF:000028; Suppressor of cytokine signaling 5; 1.
DR Gene3D; 3.30.505.10; SH2 domain; 1.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR022252; SOCS4/SOCS5_dom.
DR InterPro; IPR001496; SOCS_box.
DR InterPro; IPR036036; SOCS_box-like_dom_sf.
DR PANTHER; PTHR10155; PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT; 1.
DR PANTHER; PTHR10155:SF18; SUPPRESSOR OF CYTOKINE SIGNALING 9 ISOFORM X1; 1.
DR Pfam; PF00017; SH2; 1.
DR Pfam; PF12610; SOCS; 1.
DR Pfam; PF07525; SOCS_box; 1.
DR SMART; SM00252; SH2; 1.
DR SMART; SM00253; SOCS; 1.
DR SMART; SM00969; SOCS_box; 1.
DR SUPFAM; SSF55550; SH2 domain; 1.
DR SUPFAM; SSF158235; SOCS box-like; 1.
DR PROSITE; PS50001; SH2; 1.
DR PROSITE; PS50225; SOCS; 1.
PE 4: Predicted;
KW Growth regulation {ECO:0000256|ARBA:ARBA00022604};
KW Reference proteome {ECO:0000313|Proteomes:UP000694568};
KW SH2 domain {ECO:0000256|ARBA:ARBA00022999, ECO:0000256|PROSITE-
KW ProRule:PRU00191};
KW Signal transduction inhibitor {ECO:0000256|ARBA:ARBA00022700};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786}.
FT DOMAIN 213..308
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT DOMAIN 303..352
FT /note="SOCS box"
FT /evidence="ECO:0000259|PROSITE:PS50225"
FT REGION 56..89
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 60..70
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 363 AA; 40564 MW; 3E83B6D32BA46C2F CRC64;
MASHELAAER PVSDGFEYGE LLSDLETVDQ SSSSPLKESW RWQGLEAAAS FLGQERVTAR
SGQGTVSSAT EMPAPGEGEG RGSSSSRTLR QKIQDAMGQC FPLKTHSAAA SAPSPQALSS
SVACASSRRK IHLSELMLDD CPFPVGSELA QKWYLIKQHT APITQPPTLD SAVVMALSWL
MDPKCHDGYR IHTQIDYIHC LVPDLLQITN LPCYWGVMDR YEAETLLEGK PEGTFLLRDS
AQEDYLFSVS FRRYGRSLHA RIEQWNHNFS FDVHDPSVFH APTVTGLLEH YKDPNSCMFF
EPLLSNPIHR TQPFTLQHIC RAVISSCTTY DGINTLPIPN ALKKHLKEYH YKQRSCSSLY
LAV
//
