ID A0A8D0AY08_SANLU Unreviewed; 416 AA.
AC A0A8D0AY08;
DT 19-JAN-2022, integrated into UniProtKB/TrEMBL.
DT 19-JAN-2022, sequence version 1.
DT 28-JAN-2026, entry version 18.
DE SubName: Full=Suppressor of cytokine signaling 9 {ECO:0000313|Ensembl:ENSSLUP00000059006.1};
OS Sander lucioperca (Pike-perch) (Perca lucioperca).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Perciformes; Percoidei; Percidae; Luciopercinae; Sander.
OX NCBI_TaxID=283035 {ECO:0000313|Ensembl:ENSSLUP00000059006.1, ECO:0000313|Proteomes:UP000694568};
RN [1] {ECO:0000313|Ensembl:ENSSLUP00000059006.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (AUG-2025) to UniProtKB.
RN [2] {ECO:0000313|Ensembl:ENSSLUP00000059006.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2025) to UniProtKB.
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC {ECO:0000256|ARBA:ARBA00004906}.
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DR AlphaFoldDB; A0A8D0AY08; -.
DR Ensembl; ENSSLUT00000060693.1; ENSSLUP00000059006.1; ENSSLUG00000025271.1.
DR GeneTree; ENSGT00940000164285; -.
DR UniPathway; UPA00143; -.
DR Proteomes; UP000694568; Unplaced.
DR GO; GO:0005942; C:phosphatidylinositol 3-kinase complex; IEA:TreeGrafter.
DR GO; GO:0046935; F:1-phosphatidylinositol-3-kinase regulator activity; IEA:TreeGrafter.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR GO; GO:0009968; P:negative regulation of signal transduction; IEA:UniProtKB-KW.
DR GO; GO:0046854; P:phosphatidylinositol phosphate biosynthetic process; IEA:TreeGrafter.
DR GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR FunFam; 3.30.505.10:FF:000028; Suppressor of cytokine signaling 5; 1.
DR Gene3D; 3.30.505.10; SH2 domain; 1.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR022252; SOCS4/SOCS5_dom.
DR InterPro; IPR001496; SOCS_box.
DR InterPro; IPR036036; SOCS_box-like_dom_sf.
DR PANTHER; PTHR10155; PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT; 1.
DR PANTHER; PTHR10155:SF18; SUPPRESSOR OF CYTOKINE SIGNALING 9 ISOFORM X1; 1.
DR Pfam; PF00017; SH2; 1.
DR Pfam; PF12610; SOCS; 1.
DR Pfam; PF07525; SOCS_box; 1.
DR SMART; SM00252; SH2; 1.
DR SMART; SM00253; SOCS; 1.
DR SMART; SM00969; SOCS_box; 1.
DR SUPFAM; SSF55550; SH2 domain; 1.
DR SUPFAM; SSF158235; SOCS box-like; 1.
DR PROSITE; PS50001; SH2; 1.
DR PROSITE; PS50225; SOCS; 1.
PE 4: Predicted;
KW Growth regulation {ECO:0000256|ARBA:ARBA00022604};
KW Reference proteome {ECO:0000313|Proteomes:UP000694568};
KW SH2 domain {ECO:0000256|ARBA:ARBA00022999, ECO:0000256|PROSITE-
KW ProRule:PRU00191};
KW Signal transduction inhibitor {ECO:0000256|ARBA:ARBA00022700};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786}.
FT DOMAIN 273..368
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT DOMAIN 363..412
FT /note="SOCS box"
FT /evidence="ECO:0000259|PROSITE:PS50225"
FT REGION 1..61
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 102..135
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 7..18
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 38..47
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 106..116
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 416 AA; 45928 MW; 445F06E7FFB533A6 CRC64;
MSLPKESGNR GKDRERGARP KVRQSRSEER RGSGGGRKGG KGKKKGMASH ELAAERPVSD
GFEYGELLSD LETVDQSSSS PLKESWRWQG LEAAASFLGQ ERVTARSGQG TVSSATEMPA
PGEGEGRGSS SSRTLRQKIQ DAMGQCFPLK THSAAASAPS PQALSSSVAC ASSRRKIHLS
ELMLDDCPFP VGSELAQKWY LIKQHTAPIT QPPTLDSVAA SASASSAASA PVQTSILPPT
EDPKCHDGYR IHTQIDYIHC LVPDLLQITN LPCYWGVMDR YEAETLLEGK PEGTFLLRDS
AQEDYLFSVS FRRYGRSLHA RIEQWNHNFS FDVHDPSVFH APTVTGLLEH YKDPNSCMFF
EPLLSNPIHR TQPFTLQHIC RAVISSCTTY DGINTLPIPN ALKKHLKEYH YKQRCD
//
