ID A0A8D0G2R4_SPHPU Unreviewed; 538 AA.
AC A0A8D0G2R4;
DT 19-JAN-2022, integrated into UniProtKB/TrEMBL.
DT 19-JAN-2022, sequence version 1.
DT 28-JAN-2026, entry version 19.
DE SubName: Full=Suppressor of cytokine signaling 5 {ECO:0000313|Ensembl:ENSSPUP00000000955.1};
GN Name=SOCS5 {ECO:0000313|Ensembl:ENSSPUP00000000955.1};
OS Sphenodon punctatus (Tuatara) (Hatteria punctata).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Lepidosauria; Sphenodontia; Sphenodontidae; Sphenodon.
OX NCBI_TaxID=8508 {ECO:0000313|Ensembl:ENSSPUP00000000955.1, ECO:0000313|Proteomes:UP000694392};
RN [1] {ECO:0000313|Ensembl:ENSSPUP00000000955.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (AUG-2025) to UniProtKB.
RN [2] {ECO:0000313|Ensembl:ENSSPUP00000000955.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2025) to UniProtKB.
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC {ECO:0000256|ARBA:ARBA00004906}.
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DR AlphaFoldDB; A0A8D0G2R4; -.
DR Ensembl; ENSSPUT00000001007.1; ENSSPUP00000000955.1; ENSSPUG00000000766.1.
DR GeneTree; ENSGT00940000159000; -.
DR OMA; CQNLFNH; -.
DR UniPathway; UPA00143; -.
DR Proteomes; UP000694392; Unplaced.
DR GO; GO:0005942; C:phosphatidylinositol 3-kinase complex; IEA:TreeGrafter.
DR GO; GO:0046935; F:1-phosphatidylinositol-3-kinase regulator activity; IEA:TreeGrafter.
DR GO; GO:0005154; F:epidermal growth factor receptor binding; IEA:Ensembl.
DR GO; GO:0030971; F:receptor tyrosine kinase binding; IEA:Ensembl.
DR GO; GO:0007259; P:cell surface receptor signaling pathway via JAK-STAT; IEA:InterPro.
DR GO; GO:0071404; P:cellular response to low-density lipoprotein particle stimulus; IEA:Ensembl.
DR GO; GO:0019221; P:cytokine-mediated signaling pathway; IEA:Ensembl.
DR GO; GO:0007173; P:epidermal growth factor receptor signaling pathway; IEA:Ensembl.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR GO; GO:0050728; P:negative regulation of inflammatory response; IEA:Ensembl.
DR GO; GO:0032715; P:negative regulation of interleukin-6 production; IEA:Ensembl.
DR GO; GO:0071638; P:negative regulation of monocyte chemotactic protein-1 production; IEA:Ensembl.
DR GO; GO:0009968; P:negative regulation of signal transduction; IEA:UniProtKB-KW.
DR GO; GO:0045629; P:negative regulation of T-helper 2 cell differentiation; IEA:Ensembl.
DR GO; GO:0046854; P:phosphatidylinositol phosphate biosynthetic process; IEA:TreeGrafter.
DR GO; GO:0032436; P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process; IEA:Ensembl.
DR GO; GO:0045627; P:positive regulation of T-helper 1 cell differentiation; IEA:Ensembl.
DR GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR GO; GO:0097699; P:vascular endothelial cell response to fluid shear stress; IEA:Ensembl.
DR CDD; cd03739; SOCS_SOCS5; 1.
DR FunFam; 3.30.505.10:FF:000028; Suppressor of cytokine signaling 5; 1.
DR Gene3D; 3.30.505.10; SH2 domain; 1.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR022252; SOCS4/SOCS5_dom.
DR InterPro; IPR037343; SOCS5_SOCS.
DR InterPro; IPR001496; SOCS_box.
DR InterPro; IPR036036; SOCS_box-like_dom_sf.
DR PANTHER; PTHR10155; PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT; 1.
DR PANTHER; PTHR10155:SF15; SUPPRESSOR OF CYTOKINE SIGNALING 5; 1.
DR Pfam; PF00017; SH2; 1.
DR Pfam; PF12610; SOCS; 1.
DR Pfam; PF07525; SOCS_box; 1.
DR SMART; SM00252; SH2; 1.
DR SMART; SM00253; SOCS; 1.
DR SMART; SM00969; SOCS_box; 1.
DR SUPFAM; SSF55550; SH2 domain; 1.
DR SUPFAM; SSF158235; SOCS box-like; 1.
DR PROSITE; PS50001; SH2; 1.
DR PROSITE; PS50225; SOCS; 1.
PE 4: Predicted;
KW Growth regulation {ECO:0000256|ARBA:ARBA00022604};
KW Reference proteome {ECO:0000313|Proteomes:UP000694392};
KW SH2 domain {ECO:0000256|ARBA:ARBA00022999, ECO:0000256|PROSITE-
KW ProRule:PRU00191};
KW Signal transduction inhibitor {ECO:0000256|ARBA:ARBA00022700};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786}.
FT DOMAIN 383..478
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT DOMAIN 473..522
FT /note="SOCS box"
FT /evidence="ECO:0000259|PROSITE:PS50225"
FT REGION 22..58
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 118..143
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 538 AA; 61549 MW; 4749E5CED47B7D9C CRC64;
MDKVGKMWNN FKYRCQNLFN HEGGNRNESI DVNSNNSSFK DRGLDVPDLA QQPSSSPLRE
SISLQLGLSP SKNSSRKNQN CVTEIPPQIV EISIEKESDD TWSTTGTTRL ARRDSYTRHA
PWGGKKKHSC STKTQSSLDS DKRFGRTRCG LQRRERRYGV SSVHDMDSVS NRTVGSRSLR
QRLQDTVGLC FPLRTYSKQS KPLFSSKRKI HLSELMLEKC PFPAGSDLAQ KWHLIKQHTA
PVSPHSTFFD TFDPSSVSTE DEEDRLRERR RLSIEEGVDP PPNAQIHTFE ATAQVNPLYK
LGPKLAPGMT EFTGDNCATP QGNCDSEEDT TTLCLQSSRQ KQRQVSGESH GHVSRQGGWK
VHTQIDYIHC LVPDLLQITG NPCYWGVMDR YEAEALLEGK PEGTFLLRDS AQEDYLFSVS
FRRYNRSLHA RIEQWNHNFS FDAHDPCVFH SSTVTGLLEH YKDPSSCMFF EPLLTVSLNR
TFPFSLQYIC RAAICRCTTY DGIDCLPLPS MLQDFLKEYH YKQKVRVRWL EREPIKTK
//
