ID A0A8D0GVZ1_SPHPU Unreviewed; 395 AA.
AC A0A8D0GVZ1;
DT 19-JAN-2022, integrated into UniProtKB/TrEMBL.
DT 19-JAN-2022, sequence version 1.
DT 28-JAN-2026, entry version 21.
DE RecName: Full=Suppressor of cytokine signaling 5 {ECO:0008006|Google:ProtNLM};
OS Sphenodon punctatus (Tuatara) (Hatteria punctata).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Lepidosauria; Sphenodontia; Sphenodontidae; Sphenodon.
OX NCBI_TaxID=8508 {ECO:0000313|Ensembl:ENSSPUP00000014737.1, ECO:0000313|Proteomes:UP000694392};
RN [1] {ECO:0000313|Ensembl:ENSSPUP00000014737.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (AUG-2025) to UniProtKB.
RN [2] {ECO:0000313|Ensembl:ENSSPUP00000014737.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2025) to UniProtKB.
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC {ECO:0000256|ARBA:ARBA00004906}.
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DR AlphaFoldDB; A0A8D0GVZ1; -.
DR Ensembl; ENSSPUT00000015725.1; ENSSPUP00000014737.1; ENSSPUG00000011375.1.
DR GeneTree; ENSGT00940000164285; -.
DR OMA; SYRIHTQ; -.
DR UniPathway; UPA00143; -.
DR Proteomes; UP000694392; Unplaced.
DR GO; GO:0005942; C:phosphatidylinositol 3-kinase complex; IEA:TreeGrafter.
DR GO; GO:0046935; F:1-phosphatidylinositol-3-kinase regulator activity; IEA:TreeGrafter.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR GO; GO:0009968; P:negative regulation of signal transduction; IEA:UniProtKB-KW.
DR GO; GO:0046854; P:phosphatidylinositol phosphate biosynthetic process; IEA:TreeGrafter.
DR GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR FunFam; 3.30.505.10:FF:000028; Suppressor of cytokine signaling 5; 1.
DR Gene3D; 3.30.505.10; SH2 domain; 1.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR022252; SOCS4/SOCS5_dom.
DR InterPro; IPR001496; SOCS_box.
DR InterPro; IPR036036; SOCS_box-like_dom_sf.
DR PANTHER; PTHR10155; PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT; 1.
DR PANTHER; PTHR10155:SF18; SUPPRESSOR OF CYTOKINE SIGNALING 9 ISOFORM X1; 1.
DR Pfam; PF00017; SH2; 1.
DR Pfam; PF12610; SOCS; 1.
DR Pfam; PF07525; SOCS_box; 1.
DR SMART; SM00252; SH2; 1.
DR SMART; SM00253; SOCS; 1.
DR SMART; SM00969; SOCS_box; 1.
DR SUPFAM; SSF55550; SH2 domain; 1.
DR SUPFAM; SSF158235; SOCS box-like; 1.
DR PROSITE; PS50001; SH2; 1.
DR PROSITE; PS50225; SOCS; 1.
PE 4: Predicted;
KW Growth regulation {ECO:0000256|ARBA:ARBA00022604};
KW Reference proteome {ECO:0000313|Proteomes:UP000694392};
KW SH2 domain {ECO:0000256|ARBA:ARBA00022999, ECO:0000256|PROSITE-
KW ProRule:PRU00191};
KW Signal transduction inhibitor {ECO:0000256|ARBA:ARBA00022700};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786}.
FT DOMAIN 243..338
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT DOMAIN 333..382
FT /note="SOCS box"
FT /evidence="ECO:0000259|PROSITE:PS50225"
FT REGION 1..59
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 22..33
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 395 AA; 44654 MW; 6065DF53B76AE1AF CRC64;
AVPEKGACVR PDRGSRGRCK GRAKEPPERR SQPLEEAEPS GPQEAEPSKG AGRSLRQKLQ
AAVGQCFPIK AGSRSPDLSS QRKIHLRELM LDTCPFPAGS ELARKWKLIK QHTAPVTEQE
ALAPPPTEDE DDRLRERRRI SIEQGVEPPP NALIHTFEVT AQINPLYKLG PKLAHGMNEL
ATDNRATLAE GDEEEEEDEE EAAVAAAATA AVPEIQDGLR VHTQIDYIHC LVPDLLQLTQ
LPCYWGVMDR YEAEALLEGK PEGTFLLRDS AQEDYLFSVS FRRYGRSLHA RIEQWNHNFS
FDVHDPSVFH APTVTGLLEH YKDPSVCMFF EPLLSNPFNR TFPFGLQHLC RAVVTCCTSY
DGIGLLPIPS TLKEYLKEYH YKQRVRVRRL DMRWI
//
