ID A0A8D0HB25_SPHPU Unreviewed; 352 AA.
AC A0A8D0HB25;
DT 19-JAN-2022, integrated into UniProtKB/TrEMBL.
DT 19-JAN-2022, sequence version 1.
DT 28-JAN-2026, entry version 17.
DE RecName: Full=Peptide chain release factor 1-like, mitochondrial {ECO:0000256|ARBA:ARBA00070847};
DE AltName: Full=Mitochondrial translational release factor 1-like {ECO:0000256|ARBA:ARBA00082737};
GN Name=MTRF1L {ECO:0000313|Ensembl:ENSSPUP00000019003.1};
OS Sphenodon punctatus (Tuatara) (Hatteria punctata).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Lepidosauria; Sphenodontia; Sphenodontidae; Sphenodon.
OX NCBI_TaxID=8508 {ECO:0000313|Ensembl:ENSSPUP00000019003.1, ECO:0000313|Proteomes:UP000694392};
RN [1] {ECO:0000313|Ensembl:ENSSPUP00000019003.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (AUG-2025) to UniProtKB.
RN [2] {ECO:0000313|Ensembl:ENSSPUP00000019003.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2025) to UniProtKB.
CC -!- FUNCTION: Mitochondrial peptide chain release factor that directs the
CC termination of translation in response to the peptide chain termination
CC codons UAA and UAG. {ECO:0000256|ARBA:ARBA00055528}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000256|ARBA:ARBA00004173}.
CC -!- SIMILARITY: Belongs to the prokaryotic/mitochondrial release factor
CC family. {ECO:0000256|ARBA:ARBA00010835}.
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DR AlphaFoldDB; A0A8D0HB25; -.
DR Ensembl; ENSSPUT00000020241.1; ENSSPUP00000019003.1; ENSSPUG00000014563.1.
DR GeneTree; ENSGT00940000155683; -.
DR Proteomes; UP000694392; Unplaced.
DR GO; GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.
DR GO; GO:0016149; F:translation release factor activity, codon specific; IEA:UniProtKB-ARBA.
DR GO; GO:0070126; P:mitochondrial translational termination; IEA:UniProtKB-ARBA.
DR FunFam; 3.30.160.20:FF:000004; Peptide chain release factor 1; 1.
DR FunFam; 3.30.70.1660:FF:000004; Peptide chain release factor 1; 1.
DR FunFam; 3.30.70.1660:FF:000011; Peptide chain release factor 1-like, mitochondrial; 1.
DR Gene3D; 3.30.160.20; -; 1.
DR Gene3D; 3.30.70.1660; -; 1.
DR InterPro; IPR005139; PCRF.
DR InterPro; IPR000352; Pep_chain_release_fac_I.
DR InterPro; IPR045853; Pep_chain_release_fac_I_sf.
DR InterPro; IPR050057; Prokaryotic/Mito_RF.
DR PANTHER; PTHR43804; LD18447P; 1.
DR PANTHER; PTHR43804:SF3; PEPTIDE CHAIN RELEASE FACTOR 1-LIKE, MITOCHONDRIAL; 1.
DR Pfam; PF03462; PCRF; 1.
DR Pfam; PF00472; RF-1; 1.
DR SMART; SM00937; PCRF; 1.
DR SUPFAM; SSF75620; Release factor; 1.
DR PROSITE; PS00745; RF_PROK_I; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW Methylation {ECO:0000256|ARBA:ARBA00022481};
KW Mitochondrion {ECO:0000256|ARBA:ARBA00023128};
KW Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917};
KW Reference proteome {ECO:0000313|Proteomes:UP000694392};
KW Transit peptide {ECO:0000256|ARBA:ARBA00022946}.
FT DOMAIN 212..228
FT /note="Prokaryotic-type class I peptide chain release
FT factors"
FT /evidence="ECO:0000259|PROSITE:PS00745"
SQ SEQUENCE 352 AA; 40475 MW; D38BEFCA022E4843 CRC64;
FLPPGVRHLA ICLLSSREHL YRCLDSQPYT LEGTLLLFPL YHRCTAQLWQ DSLKMKLQLN
FMVCRKENFR FKGCTILVLQ IALLLIPSED VDHNDIIMEV TAGVGGQEAM LFTEEMFDMY
QQYAAYKNWR FDVLEYAPCD IGGLRHASAV VVGLKAYRHM KFEGGVHRVQ RVPKTEKQGR
IHTSTMTVAI LPQPTEINLK INPKDLWIET KRASGAGGQH VNKTESAVRI VHIPTGVVSE
CQQDRSQIRN RATAMQVLRA KLYSIMLEEE TSKRCIARKV QIGTKGRSEK IRTYNFPQNR
VTDHRISRSV HHIERFLLGE ELLDEMIQSL KEYADYESLM EIISENDQPN VT
//
